Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice.
Allodynia
Analgesic
Anxiety
Depression
Natural products
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
25 Apr 2024
25 Apr 2024
Historique:
received:
30
08
2023
accepted:
27
03
2024
medline:
25
4
2024
pubmed:
25
4
2024
entrez:
25
4
2024
Statut:
aheadofprint
Résumé
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy. Diosmetin, an aglycone of the flavonoid glycoside diosmin found in citrus fruits and the leaves of Olea europaea L., has antinociceptive, anti-inflammatory, and antioxidant properties. Here, we investigated the effect of diosmetin on nociceptive behaviors and comorbidities in an experimental fibromyalgia model induced by reserpine in mice. To induce the experimental fibromyalgia model, a protocol of subcutaneous injections of reserpine (1 mg/kg) was used once a day for three consecutive days in adult male Swiss mice. Mice received oral diosmetin on the fourth day after the first reserpine injection. Nociceptive (mechanical allodynia, muscle strength, and thermal hyperalgesia) and comorbid (depressive-like and anxiety behavior) parameters were evaluated. Potential adverse effects associated with diosmetin plus reserpine (locomotor alteration, cataleptic behavior, and body weight and temperature changes) were also evaluated. Oral diosmetin (0.015-1.5 mg/kg) reduced the mechanical allodynia, thermal hyperalgesia, and loss of muscle strength induced by reserpine. Diosmetin (0.15 mg/kg) also attenuated depressive-like and anxiety behaviors without causing locomotor alteration, cataleptic behavior, and alteration in weight and body temperature of mice. Overall, diosmetin can be an effective and safe therapeutic alternative to treat fibromyalgia symptoms, such as pain, depression and anxiety.
Identifiants
pubmed: 38662182
doi: 10.1007/s10787-024-01473-4
pii: 10.1007/s10787-024-01473-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : #23038.002125/2021-85
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : Grant #0036/2021
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : #88882.182170/2018-01
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : #21/2551-0001966-2
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : #304985/2020-1
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : #307690/2021-0
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Références
Adamante G, de Almeida AS, Rigo FK et al (2019) Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice. Life Sci 216:215–226. https://doi.org/10.1016/j.lfs.2018.11.029
doi: 10.1016/j.lfs.2018.11.029
pubmed: 30447303
Arnold LM, Gebke KB, Choy EHS (2016) Fibromyalgia: Management strategies for primary care providers. Int J Clin Pract 70:99–112. https://doi.org/10.1111/IJCP.12757
doi: 10.1111/IJCP.12757
pubmed: 26817567
Atwal N, Casey SL, Mitchell VA, Vaughan CW (2019) THC and gabapentin interactions in a mouse neuropathic pain model. Neuropharmacology 144:115–121. https://doi.org/10.1016/j.neuropharm.2018.10.006
doi: 10.1016/j.neuropharm.2018.10.006
pubmed: 30312630
Brederson J-D, Jarvis FM, Honore PS, Surowy C (2011) Fibromyalgia: mechanisms, current treatment and animal models. Curr Pharm Biotechnol 12:1613–1626. https://doi.org/10.2174/138920111798357258
doi: 10.2174/138920111798357258
pubmed: 21466451
Brum ES, Fialho MFP, Fischer SPM et al (2020) Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. Mol Neurobiol 57(4202):4217. https://doi.org/10.1007/s12035-020-01996-1
doi: 10.1007/s12035-020-01996-1
Brum ES, Becker G, Fialho MFP, Oliveira SM (2022) Animal models of fibromyalgia: What is the best choice? Pharmacol Ther 230:107959. https://doi.org/10.1016/j.pharmthera.2021.107959
doi: 10.1016/j.pharmthera.2021.107959
pubmed: 34265360
Brusco I, Justino AB, Silva CR et al (2019) Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice. Biochem Pharmacol 168:119–132. https://doi.org/10.1016/j.bcp.2019.06.023
doi: 10.1016/j.bcp.2019.06.023
pubmed: 31254493
Brusco I, Justino AB, Silva CR et al (2021) Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice. Eur J Pharmacol 895:173870. https://doi.org/10.1016/j.ejphar.2021.173870
doi: 10.1016/j.ejphar.2021.173870
pubmed: 33476653
Camponogara C, Brum ES, Pegoraro NS et al (2021) Diosmetin, a novel transient receptor potential vanilloid 1 antagonist, alleviates the UVB radiation-induced skin inflammation in mice. Inflammopharmacology 29:879–895. https://doi.org/10.1007/s10787-021-00802-1
doi: 10.1007/s10787-021-00802-1
pubmed: 33751333
Carballo-Villalobos AI, González-Trujano ME, Pellicer F et al (2018) Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats. Biomed Pharmacother 97:310–320. https://doi.org/10.1016/j.biopha.2017.10.077
doi: 10.1016/j.biopha.2017.10.077
pubmed: 29091880
Carradori S, Gidaro MC, Petzer A et al (2016) Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids. J Agric Food Chem 64:9004–9011. https://doi.org/10.1021/acs.jafc.6b03529
doi: 10.1021/acs.jafc.6b03529
pubmed: 27933876
Chaplan SR, Bach FW, Pogrel JW et al (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55–63. https://doi.org/10.1016/0165-0270(94)90144-9
doi: 10.1016/0165-0270(94)90144-9
pubmed: 7990513
Choy EHS (2015) The role of sleep in pain and fibromyalgia. Nat Rev Rheumatol 11:513–520
doi: 10.1038/nrrheum.2015.56
pubmed: 25907704
Choy E, Perrot S, Leon T et al (2010) A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res 10:102. https://doi.org/10.1186/1472-6963-10-102
doi: 10.1186/1472-6963-10-102
pubmed: 20420681
pmcid: 2874550
Clauw DJ (2014) Fibromyalgia. JAMA 311:1547. https://doi.org/10.1001/jama.2014.3266
doi: 10.1001/jama.2014.3266
pubmed: 24737367
Clauw DJ (2015) Fibromyalgia and related conditions. Mayo Clin Proc 90:680–692. https://doi.org/10.1016/j.mayocp.2015.03.014
doi: 10.1016/j.mayocp.2015.03.014
pubmed: 25939940
De la Luz-Cuellar YE, Rodríguez-Palma EJ, Franco-Enzástiga Ú et al (2019) Blockade of spinal receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats. Eur J Pharmacol 858:1724443
doi: 10.1016/j.ejphar.2019.172443
de Oliveira DR, Todo AH, Rêgo GM et al (2018) Flavones-bound in benzodiazepine site on GABA A receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. Eur J Pharmacol 831:77–86. https://doi.org/10.1016/j.ejphar.2018.05.004
doi: 10.1016/j.ejphar.2018.05.004
Derry S, Cording M, Wiffen PJ et al (2016) Pregabalin for pain in fibromyalgia in adults. Cochrane Database Syst Rev 2019:291–292. https://doi.org/10.1002/14651858.CD011790.pub2
doi: 10.1002/14651858.CD011790.pub2
Dewanjee S, Hossain S, Ansari F (2023) Heliyon Review article A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights. Heliyon 9:e15346. https://doi.org/10.1016/j.heliyon.2023.e15346
doi: 10.1016/j.heliyon.2023.e15346
pubmed: 37159686
pmcid: 10163606
Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441–462. https://doi.org/10.1146/annurev.pa.20.040180.002301
doi: 10.1146/annurev.pa.20.040180.002301
pubmed: 7387124
Doppler K, Rittner HL, Deckart M, Sommer C (2015) Reduced dermal nerve fiber diameter in skin biopsies of patients with fibromyalgia. Pain 156:2319–2325. https://doi.org/10.1097/j.pain.0000000000000285
doi: 10.1097/j.pain.0000000000000285
pubmed: 26164586
Ferrarini EG, Paes RS, Baldasso GM et al (2022) Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. Biomed Pharmacother 154:113552. https://doi.org/10.1016/j.biopha.2022.113552
doi: 10.1016/j.biopha.2022.113552
pubmed: 35988425
Fialho MFP, Brum ES, Becker G et al (2023) Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms. Pharmaceutics 15:1136. https://doi.org/10.3390/pharmaceutics15041136
doi: 10.3390/pharmaceutics15041136
pubmed: 37111622
pmcid: 10143169
Fischer SPM, Brusco I, Brum ES et al (2020) Involvement of TRPV1 and the efficacy of α-spinasterol on experimental fibromyalgia symptoms in mice. Neurochem Int 134:104673. https://doi.org/10.1016/j.neuint.2020.104673
doi: 10.1016/j.neuint.2020.104673
pubmed: 31926196
Garcia Mendes MP, Carvalho dos Santos D, Rezende MJS et al (2021) Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia. Toxicon 195:104–110. https://doi.org/10.1016/j.toxicon.2021.03.012
doi: 10.1016/j.toxicon.2021.03.012
pubmed: 33753115
Gavva NR, Treanor JJS, Garami A et al (2008) Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136:202–210. https://doi.org/10.1016/j.pain.2008.01.024
doi: 10.1016/j.pain.2008.01.024
pubmed: 18337008
Gibson HE, Edwards JG, Page RS et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57:746–759. https://doi.org/10.1016/j.neuron.2007.12.027
doi: 10.1016/j.neuron.2007.12.027
pubmed: 18341994
pmcid: 2698707
Guo Y, Li D, Cen X et al (2022) Diosmetin protects against cardiac hypertrophy via p62/Keap1/Nrf2 signaling pathway. Oxid Med Cell Longev 2022:1–14. https://doi.org/10.1155/2022/8367997
doi: 10.1155/2022/8367997
Häuser W, Ablin J, Fitzcharles M-A et al (2015) Fibromyalgia. Nat Rev Dis Prim 1:15022. https://doi.org/10.1038/nrdp.2015.22
doi: 10.1038/nrdp.2015.22
pubmed: 27189527
Hernandez-Leon A, De la Luz-Cuellar YE, Granados-Soto V et al (2018) Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia. Horm Behav 97:39–46. https://doi.org/10.1016/j.yhbeh.2017.10.011
doi: 10.1016/j.yhbeh.2017.10.011
pubmed: 29080671
Huang W, Calvo M, Karu K et al (2013) A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy. Pain 154:560–575. https://doi.org/10.1016/j.pain.2012.12.023
doi: 10.1016/j.pain.2012.12.023
pubmed: 23415009
Julius D (2013) TRP channels and pain. Annu Rev Cell Dev Biol 29:355–384. https://doi.org/10.1146/annurev-cellbio-101011-155833
doi: 10.1146/annurev-cellbio-101011-155833
pubmed: 24099085
Kaur A, Singh L, Singh N et al (2019) Ameliorative effect of imperatorin in chemically induced fibromyalgia: role of NMDA/NFkB mediated downstream signaling. Biochem Pharmacol 166:56–69. https://doi.org/10.1016/j.bcp.2019.05.012
doi: 10.1016/j.bcp.2019.05.012
pubmed: 31075267
Klein CP, Sperotto NDM, Maciel IS et al (2014) Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. Neuropharmacology 86:57–66. https://doi.org/10.1016/j.neuropharm.2014.05.043
doi: 10.1016/j.neuropharm.2014.05.043
pubmed: 24929111
Kosek E, Cohen M, Baron R et al (2016) Do we need a third mechanistic descriptor for chronic pain states? Pain 157:1382–1386. https://doi.org/10.1097/j.pain.0000000000000507
doi: 10.1097/j.pain.0000000000000507
pubmed: 26835783
Li S, Han J, Wang D, sheng, et al (2016) Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. Metab Brain Dis 31:455–463. https://doi.org/10.1007/s11011-015-9786-6
doi: 10.1007/s11011-015-9786-6
pubmed: 26729203
Liao W, Ning Z, Chen L et al (2014) Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem 62:8648–8654. https://doi.org/10.1021/jf502359x
doi: 10.1021/jf502359x
pubmed: 25075433
Littlejohn G (2015) Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome. Nat Rev Rheumatol 11:639–648. https://doi.org/10.1038/nrrheum.2015.100
doi: 10.1038/nrrheum.2015.100
pubmed: 26241184
Littlejohn G, Guymer E (2018) Neurogenic inflammation in fibromyalgia. Semin Immunopathol 40:291–300. https://doi.org/10.1007/s00281-018-0672-2
doi: 10.1007/s00281-018-0672-2
pubmed: 29556959
Lu Y, Zhu S, He Y et al (2019) Phytochemical profile and antidepressant effect of Ormosia henryi prain leaf ethanol extract. Int J Mol Sci 20:3396. https://doi.org/10.3390/ijms20143396
doi: 10.3390/ijms20143396
pubmed: 31295954
pmcid: 6678957
Macfarlane GJ, Kronisch C, Dean LE et al (2017) EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis 76:318–328. https://doi.org/10.1136/annrheumdis-2016-209724
doi: 10.1136/annrheumdis-2016-209724
pubmed: 27377815
Mei Z, Du L, Liu X et al (2022) Diosmetin alleviated cerebral ischemia/reperfusion injury in vivo and in vitro by inhibiting oxidative stress via the SIRT1/Nrf2 signaling pathway. Food Funct 13:198–212. https://doi.org/10.1039/D1FO02579A
doi: 10.1039/D1FO02579A
pubmed: 34881386
Mitra R, Nersesyan A, Pentland K et al (2022) Diosmin and its glycocalyx restorative and <scp>anti-inflammatory</scp> effects on injured blood vessels. FASEB J 36:e22630. https://doi.org/10.1096/fj.202200053RR
doi: 10.1096/fj.202200053RR
pubmed: 36315163
Nagakura Y, Oe T, Aoki T, Matsuoka N (2009) Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: a putative animal model of fibromyalgia. Pain 146:26–33. https://doi.org/10.1016/j.pain.2009.05.024
doi: 10.1016/j.pain.2009.05.024
pubmed: 19646816
Nagakura Y, Ohsaka N, Azuma R et al (2018) Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice. Physiol Behav 194:505–514. https://doi.org/10.1016/j.physbeh.2018.07.007
doi: 10.1016/j.physbeh.2018.07.007
pubmed: 29981307
Oe T, Tsukamoto M, Nagakura Y (2010) Reserpine causes biphasic nociceptive sensitivity alteration in conjunction with brain biogenic amine tones in rats. Neuroscience 169:1860–1871. https://doi.org/10.1016/j.neuroscience.2010.06.061
doi: 10.1016/j.neuroscience.2010.06.061
pubmed: 20600634
Patel K, Gadewar M, Tahilyani V, Patel DK (2013) A review on pharmacological and analytical aspects of diosmetin: A concise report. Chin J Integr Med 19:792–800. https://doi.org/10.1007/s11655-013-1595-3
doi: 10.1007/s11655-013-1595-3
pubmed: 24092244
Pedron C, Antunes FTT, Rebelo IN et al (2021) Phoneutria nigriventer Tx3-–3 peptide toxin reduces fibromyalgia symptoms in mice. Neuropeptides 85:102094. https://doi.org/10.1016/j.npep.2020.102094
doi: 10.1016/j.npep.2020.102094
pubmed: 33171335
Raja SN, Carr DB, Cohen M et al (2020) The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain 161:1976–1982. https://doi.org/10.1097/j.pain.0000000000001939
doi: 10.1097/j.pain.0000000000001939
pubmed: 32694387
pmcid: 7680716
Rehm SE, Koroschetz J, Gockel U et al (2010) A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles. Rheumatology 49:1146–1152. https://doi.org/10.1093/rheumatology/keq066
doi: 10.1093/rheumatology/keq066
pubmed: 20236955
Sarzi-Puttini P, Giorgi V, Marotto D (2020) Atzeni F (2020) Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment. Nat Rev Rheumatol 1611(16):645–660. https://doi.org/10.1038/s41584-020-00506-w
doi: 10.1038/s41584-020-00506-w
Taguchi T, Katanosaka K, Yasui M et al (2015) Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain 156:415–427. https://doi.org/10.1097/01.j.pain.0000460334.49525.5e
doi: 10.1097/01.j.pain.0000460334.49525.5e
pubmed: 25599239
Terzian AL, Aguiar DC, Guimarães FS, Moreira FA (2009) Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray. Euro Neuropsychopharmacol 19(3):188–195. https://doi.org/10.1016/j.euroneuro.2008.11.004
doi: 10.1016/j.euroneuro.2008.11.004
Treede RD, Rief W, Barke A et al (2015) A classification of chronic pain for ICD-11. Pain 156:1003–1007. https://doi.org/10.1097/j.pain.0000000000000160
doi: 10.1097/j.pain.0000000000000160
pubmed: 25844555
pmcid: 4450869
Yang Y, Gong X, Huang L et al (2017) Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice. Oncotarget 8:30723
doi: 10.18632/oncotarget.15413
pubmed: 28430612
pmcid: 5458162
Yao X, Li L, Kandhare A et al (2019) Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin a plant flavonoid polyphenol. Exp Ther Med 1343:1355
Zhao L, Tao X, Wang Q et al (2024) Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway. Biomed Pharmacother 170:116067. https://doi.org/10.1016/j.biopha.2023.116067
doi: 10.1016/j.biopha.2023.116067
pubmed: 38150877
Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109–110. https://doi.org/10.1016/0304-3959(83)90201-4
doi: 10.1016/0304-3959(83)90201-4
pubmed: 6877845