Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review.
Angiogenesis
Anticancer activity
Apoptosis
Copper nanoparticles
Copper-based compounds
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
25 Apr 2024
25 Apr 2024
Historique:
received:
29
12
2023
accepted:
03
02
2024
medline:
25
4
2024
pubmed:
25
4
2024
entrez:
25
4
2024
Statut:
epublish
Résumé
Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.
Identifiants
pubmed: 38662225
doi: 10.1007/s00432-024-05641-5
pii: 10.1007/s00432-024-05641-5
doi:
Substances chimiques
Copper
789U1901C5
Antineoplastic Agents
0
Coordination Complexes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
213Informations de copyright
© 2024. The Author(s).
Références
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