Acetyl-CoA-dependent ac

Ac(4)C Acetyl-CoA Bone marrow mesenchymal stem cells Inflammation Osteogenic differentiation

Journal

International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259

Informations de publication

Date de publication:
24 Apr 2024
Historique:
received: 31 01 2024
revised: 10 04 2024
accepted: 17 04 2024
medline: 26 4 2024
pubmed: 26 4 2024
entrez: 25 4 2024
Statut: aheadofprint

Résumé

The impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimately affecting osteogenic differentiation. The mitochondrial dysfunction and impaired osteogenic potential upon inflammatory conditions accompanied by the reduced acetyl-CoA content, which in turn suppressed N4-acetylation (ac

Identifiants

DOI: 10.1016/j.intimp.2024.112124 PMID: 38663312
pubmed: 38663312
pii: S1567-5769(24)00642-8
doi: 10.1016/j.intimp.2024.112124
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112124

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Auteurs

Yujia Bai (Y)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: baiyj23@mail2.sysu.edu.cn.

Wenjie Zhang (W)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: zhangwj233@mail2.sysu.edu.cn.

Lili Hao (L)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: haolli@mail2.sysu.edu.cn.

Yiqing Zhao (Y)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: zhaoyq25@mail2.sysu.edu.cn.

I-Chen Tsai (IC)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: tsaiic@mail2.sysu.edu.cn.

Yipin Qi (Y)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: qiyp3@mail.sysu.edu.cn.

Qiong Xu (Q)

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, China; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China. Electronic address: xqiong@mail.sysu.edu.cn.

Classifications MeSH