Reduced intensity versus myeloablative conditioning for MDS: long-term results of an EBMT phase III study (RICMAC).


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
25 Apr 2024
Historique:
received: 02 01 2024
accepted: 05 04 2024
revised: 03 04 2024
medline: 26 4 2024
pubmed: 26 4 2024
entrez: 25 4 2024
Statut: aheadofprint

Résumé

Short-term outcome of myeloablative (MAC) and reduced intensity (RIC) conditioning in the prospective randomized international EBMT RICMAC study in patients with myelodyplastic syndrome (MDS) was comparable but longer follow up is lacking. Patients with MDS aged 18-65 years were randomized to receive MAC (N = 64) with busulfan/cyclophosphamide or RIC (n = 65) with busulfan/fludarabine followed by stem cell transplantation -(HCT) from HLA matched or mismatched donor. After a median follow-up of 6.2 (0.4-12.5) years, 10-year OS and RFS were 54.0% and 43.9% for RIC and 44.4% and 44.2% for MAC (p = 0.15 and p = 0.78), respectively. Since the first report, 6 patients died on NRM, 4 after RIC, and 2 after MAC. Similarly, 8 patients relapsed (4 in each arm), increasing the number of relapsed patients to 28. The second HCT was performed in 18 pts, 8 in the MAC, and 10 in the RIC arm. In a multivariate analysis, ECOG status and chemotherapy prior to HCT were independent risk factors for OS and RFS, ECOG and low cytogenetic risk for NRM and chemotherapy prior to HCT for RI. Patients with low cytogenetic risk had better OS [p = 0.002], RFS [p = 0.02], and NRM (p = 0.015) after RIC as compared to MAC.

Identifiants

pubmed: 38664589
doi: 10.1038/s41409-024-02282-7
pii: 10.1038/s41409-024-02282-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Christian Niederwieser (C)

University Medical Center Hamburg-Eppendorf, Department of Stem Cell Transplantation, Hamburg, Germany.

Simona Iacobelli (S)

Università Tor Vergata, Rome, Italy.

Georg-Nikolaus Franke (GN)

University Hospital Leipzig, Leipzig, Germany.

Linda Koster (L)

EBMT Leiden Study Unit, Leiden, The Netherlands.

Marleen van Os (M)

EBMT Leiden Study Unit, Leiden, The Netherlands.

Uwe Platzbecker (U)

University Hospital Leipzig, Leipzig, Germany.

Kai Hübel (K)

University of Cologne, Cologne, Germany.

Christof Scheid (C)

University of Cologne, Cologne, Germany.

Lutz Peter Müller (LP)

University Hospital Halle (Saale), Department of Internal Medicine IV, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Matthias Stelljes (M)

University of Münster, Münster, Germany.

Elena Morozova (E)

RM Gorbacheva Research Institute, Pavlov University, Saint Petersburg, Russian Federation.

Jakob Passweg (J)

University Hospital Basel, Basel, Switzerland.

Francesco Onida (F)

Fondazione IRCC Ca' Granda Ospedale Maggiore Policlinico, University of Milano, Milan, Italy.

Peter Dreger (P)

University of Heidelberg, Heidelberg, Germany.

Riccardo Saccardi (R)

Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

Marco Ladetto (M)

Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Urpu Salmenniemi (U)

Helsinki University Hospital, Helsiniki, Finland.

Wolfgang Bethge (W)

University Hospital Tübingen, Department of Hematology, Oncology, Clinical Immunology and Rheumatology Tübingen, Tübingen, Germany.

Xavier Poiré (X)

Cliniques Universitaires St-Luc, Brussels, Belgium.

Guido Kobbe (G)

University Hospital Düsseldorf, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.

Donal P McLornan (DP)

Department of Haematology and Stem Cell Transplantation, University College London Hospital, London, United Kingdom.

Marie Robin (M)

Hôpital Saint Louis, Assistance Publique Hôpitaux Paris, Université de Paris Cité, Paris, France.

Nicolaus Kröger (N)

University Medical Center Hamburg-Eppendorf, Department of Stem Cell Transplantation, Hamburg, Germany. nkroeger@uke.de.

Classifications MeSH