Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease.
Journal
BJC reports
ISSN: 2731-9377
Titre abrégé: BJC Rep
Pays: England
ID NLM: 9918752188106676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
03
2023
revised:
09
05
2023
accepted:
12
05
2023
medline:
1
1
2023
pubmed:
1
1
2023
entrez:
26
4
2024
Statut:
ppublish
Résumé
Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationship between these and patient outcome. We studied 1926 unrelated patients with advanced CRC from COIN and COIN-B. Of 205 CRC-risk SNPs, 19 were directly genotyped and 162 were imputed, and of 53 risk genes, 52 were tested. An additive Cox model for overall survival was adjusted for known prognostic factors. For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of Eleven SNPs or genes were nominally associated with survival under an additive model. Only rs117079142 mapping to rs117079142 and rs9924886 may represent potential prognostic biomarkers for CRC.
Sections du résumé
Background
UNASSIGNED
Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationship between these and patient outcome.
Methods
UNASSIGNED
We studied 1926 unrelated patients with advanced CRC from COIN and COIN-B. Of 205 CRC-risk SNPs, 19 were directly genotyped and 162 were imputed, and of 53 risk genes, 52 were tested. An additive Cox model for overall survival was adjusted for known prognostic factors. For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of
Results
UNASSIGNED
Eleven SNPs or genes were nominally associated with survival under an additive model. Only rs117079142 mapping to
Conclusion
UNASSIGNED
rs117079142 and rs9924886 may represent potential prognostic biomarkers for CRC.
Identifiants
pubmed: 38665548
doi: 10.1038/s44276-023-00003-z
pii: 3
pmc: PMC11041780
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.