The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.

DCM basal ganglia effective connectivity inferior frontal gyrus response inhibition

Journal

Psychoradiology
ISSN: 2634-4416
Titre abrégé: Psychoradiology
Pays: England
ID NLM: 9918317784806676

Informations de publication

Date de publication:
2023
Historique:
received: 26 05 2023
revised: 13 08 2023
accepted: 12 09 2023
medline: 26 4 2024
pubmed: 26 4 2024
entrez: 26 4 2024
Statut: epublish

Résumé

The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains controversial. The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors (i.e. sex) and behavioral performance. Here, we capitalize on the recent progress in robust and biologically plausible directed causal modeling (DCM-PEB) and a large response inhibition dataset ( The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and rThal. Direct comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and rThal. In addition, sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation, while better inhibitory performance was associated with stronger rThal to rIFG communication. Furthermore, control analyses did not reveal a similar key communication in a left lateralized model. Together, these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.

Sections du résumé

Background UNASSIGNED
The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains controversial.
Objective UNASSIGNED
The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors (i.e. sex) and behavioral performance.
Methods UNASSIGNED
Here, we capitalize on the recent progress in robust and biologically plausible directed causal modeling (DCM-PEB) and a large response inhibition dataset (
Results UNASSIGNED
The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and rThal. Direct comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and rThal. In addition, sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation, while better inhibitory performance was associated with stronger rThal to rIFG communication. Furthermore, control analyses did not reveal a similar key communication in a left lateralized model.
Conclusions UNASSIGNED
Together, these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.

Identifiants

DOI: 10.1093/psyrad/kkad016 PMID: 38666118 PMC: PMC10917375
pubmed: 38666118
doi: 10.1093/psyrad/kkad016
pii: kkad016
pmc: PMC10917375
doi:

Types de publication

Journal Article

Langues

eng

Pagination

kkad016

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of West China School of Medicine/West China Hospital (WCSM/WCH) of Sichuan University.

Déclaration de conflit d'intérêts

K.M.K. holds the position of Editor-in-Chief and B.B. is a member of editorial board of Psychoradiology. They were blinded from the review process and making decisions on the manuscript. Disclaimer: Any opinions, findings, conclusions or recommendations expressed in this publication do not reflect the views of the Government of the Hong Kong Special Administrative Region or the Innovation and Technology Commission.

Auteurs

Qian Zhuang (Q)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province 311121, China.

Lei Qiao (L)

School of Psychology, Shenzhen University, Shenzhen 518060, China.

Lei Xu (L)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, 610068, China.

Shuxia Yao (S)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.

Shuaiyu Chen (S)

Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province 311121, China.

Xiaoxiao Zheng (X)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.
Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Jialin Li (J)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.

Meina Fu (M)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.

Keshuang Li (K)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.
School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.

Deniz Vatansever (D)

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
ORCID: 0000-0002-2494-9945

Stefania Ferraro (S)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.

Keith M Kendrick (KM)

The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, The University of Electronic Science and Technology of China, Chengdu, Sichuan Province 611731, China.
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
ORCID: 0000-0002-0371-5904

Benjamin Becker (B)

State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China.
Department of Psychology, The University of Hong Kong, Hong Kong 999077, China.
ORCID: 0000-0002-9014-9671

Classifications MeSH