A New 4-Thiazolidinone Derivative (Les-6490) as a Gut Microbiota Modulator: Antimicrobial and Prebiotic Perspectives.

4-thiazolidinones anti-inflammatory activity antimicrobial activity gut microbiota metagenomic sequencing rats

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
22 Mar 2024
Historique:
received: 16 02 2024
revised: 20 03 2024
accepted: 21 03 2024
medline: 26 4 2024
pubmed: 26 4 2024
entrez: 26 4 2024
Statut: epublish

Résumé

A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and showed activity against

Identifiants

DOI: 10.3390/antibiotics13040291 PMID: 38666967
pubmed: 38666967
pii: antibiotics13040291
doi: 10.3390/antibiotics13040291
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministry of Health of Ukraine
ID : 0121U100690, 0120U102460, 0123U100153
Organisme : National Research Foundation of Ukraine
ID : 2020.02/0035

Auteurs

Yulian Konechnyi (Y)

Department of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
ORCID: 0000-0003-4789-1675

Tetyana Rumynska (T)

Department of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
Institute of Animal Biology NAAS, Vasylya Stusa St., 38, 79034 Lviv, Ukraine.
ORCID: 0000-0002-0669-5865

Ihor Yushyn (I)

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
ORCID: 0000-0001-7625-4531

Serhii Holota (S)

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
Department of Organic and Pharmaceutical Chemistry, Lesya Ukrainka Volyn National University, 13 Volya Ave., 43025 Lutsk, Ukraine.
ORCID: 0000-0002-9892-437X

Vira Turkina (V)

Research Institute of Epidemiology and Hygiene, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
Department of Biological Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
ORCID: 0000-0002-0660-8485

Mariana Ryviuk Rydel (M)

Department of Intellectual Property, Information and Corporate Law, Ivan Franko National University of Lviv, 1 Universytetska St., 79000 Lviv, Ukraine.
Department of Scientific and Medical Information and Intellectual Property, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.

Alicja Sękowska (A)

Microbiology Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 9 Maria Skłodowska-Curie St., 85-094 Bydgoszcz, Poland.
ORCID: 0000-0001-6380-3968

Yuriy Salyha (Y)

Institute of Animal Biology NAAS, Vasylya Stusa St., 38, 79034 Lviv, Ukraine.

Olena Korniychuk (O)

Department of Microbiology, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.

Roman Lesyk (R)

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine.
Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.
ORCID: 0000-0002-3322-0080

Classifications MeSH