Impact of Pregnancy on Breast Cancer Features and Prognosis.
breast cancer
pregnancy
pregnancy associated breast cancer (PABC)
prognosis
Journal
Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503
Informations de publication
Date de publication:
19 Apr 2024
19 Apr 2024
Historique:
received:
18
03
2024
revised:
11
04
2024
accepted:
17
04
2024
medline:
26
4
2024
pubmed:
26
4
2024
entrez:
26
4
2024
Statut:
epublish
Résumé
pregnancy-associated breast cancer (PABC) affects one in 3000 pregnancies, often presenting with aggressive features. We retrospectively evaluated a cohort of 282 young BC patients (≤45 years old) treated between 1995 and 2019, dividing them into three groups: nulliparous women, women with PABC (diagnosed within 2 years since last pregnancy) and women with BC diagnosed > 2 years since last pregnancy. This last group was further stratified according to the time between pregnancy and BC. The analysis encompassed histological factors (tumor size, histotype, grading, nodal involvement, multifocality, lympho-vascular invasion, hormone receptor expression, Ki-67 index, and HER2 expression), type of surgery and recurrence. Age at diagnosis was younger in nulliparous than in parous women ( in our experience, pregnancy is not an independent adverse prognostic factor for BC DFS.
Sections du résumé
BACKGROUND
BACKGROUND
pregnancy-associated breast cancer (PABC) affects one in 3000 pregnancies, often presenting with aggressive features.
METHODS
METHODS
We retrospectively evaluated a cohort of 282 young BC patients (≤45 years old) treated between 1995 and 2019, dividing them into three groups: nulliparous women, women with PABC (diagnosed within 2 years since last pregnancy) and women with BC diagnosed > 2 years since last pregnancy. This last group was further stratified according to the time between pregnancy and BC. The analysis encompassed histological factors (tumor size, histotype, grading, nodal involvement, multifocality, lympho-vascular invasion, hormone receptor expression, Ki-67 index, and HER2 expression), type of surgery and recurrence.
RESULTS
RESULTS
Age at diagnosis was younger in nulliparous than in parous women (
CONCLUSIONS
CONCLUSIONS
in our experience, pregnancy is not an independent adverse prognostic factor for BC DFS.
Identifiants
pubmed: 38668074
pii: curroncol31040171
doi: 10.3390/curroncol31040171
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM