Antifungal Activity of Ribosome-Inactivating Proteins.

Ribosome Inactivating Proteins / pharmacology Antifungal Agents / pharmacology Plant Proteins / pharmacology Fungi / drug effects Plant Diseases / microbiology Plants, Genetically Modified Animals Fungicides, Industrial / pharmacology
adenine polynucleotide glycosylase antifungal protein fungus-resistant transgenic plants plant pathogenic fungi rRNA glycosylase (EC 3.2.2.22) ribosome-inactivating protein (RIP)

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
15 Apr 2024
Historique:
received: 14 03 2024
revised: 04 04 2024
accepted: 12 04 2024
medline: 26 4 2024
pubmed: 26 4 2024
entrez: 26 4 2024
Statut: epublish

Résumé

The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections. Among the plant proteins that play a role in defense are ribosome-inactivating proteins (RIPs), enzymes obtained mainly from angiosperms that, in addition to inactivating ribosomes, have been studied as antiviral, fungicidal, and insecticidal proteins. In this review, we summarize and discuss the potential use of RIPs (and other proteins with similar activity) as antifungal agents, with special emphasis on RIP/fungus specificity, possible mechanisms of antifungal action, and the use of RIP genes to obtain fungus-resistant transgenic plants. It also highlights the fact that these proteins also have antiviral and insecticidal activity, which makes them very versatile tools for crop protection.

Identifiants

DOI: 10.3390/toxins16040192 PMID: 38668617
pubmed: 38668617
pii: toxins16040192
doi: 10.3390/toxins16040192
pii:
doi:

Substances chimiques

Ribosome Inactivating Proteins EC 3.2.2.22
Antifungal Agents 0
Plant Proteins 0
Fungicides, Industrial 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Consejería de Educación, Junta de Castilla y León
ID : VA033G19

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Auteurs

Rosario Iglesias (R)

Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.

Lucía Citores (L)

Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.
ORCID: 0000-0003-3784-5042

Claudia C Gay (CC)

Laboratory of Protein Research, Institute of Basic and Applied Chemistry of Northeast Argentina (UNNE-CONICET), Faculty of Exact and Natural Sciences and Surveying, Av. Libertad 5470, Corrientes 3400, Argentina.
ORCID: 0000-0001-9561-2090

José M Ferreras (JM)

Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.
ORCID: 0000-0003-4816-5878

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines inactivant les ribosomes › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Eucaryotes › Champignons › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Phénomènes physiologiques des plantes › Maladies des plantes › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Végétaux génétiquement modifiés › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Eucaryotes › Animaux › Antifungal Activity of Ribosome-Inactivating Proteins.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Fongicides industriels › Antifungal Activity of Ribosome-Inactivating Proteins.