Dietary intake of copper and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.

Humans Stomach Neoplasms / epidemiology Copper / administration & dosage Female Male Middle Aged Case-Control Studies Aged Diet Logistic Models Adult Odds Ratio Risk Factors

Gastric cancer case–control consortium copper diet pooled analysis

Journal

International journal of epidemiology

ISSN: 1464-3685

Titre abrégé: Int J Epidemiol

Pays: England

ID NLM: 7802871

Informations de publication

Date de publication:
11 Apr 2024

Historique:

received: 27 10 2023

accepted: 16 04 2024

medline: 27 4 2024

pubmed: 27 4 2024

entrez: 26 4 2024

Statut: ppublish

Résumé

Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC. Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes. The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.

RESULTS RESULTS

The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.

CONCLUSIONS CONCLUSIONS

The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.

Identifiants

DOI: 10.1093/ije/dyae059 PMID: 38670544

pubmed: 38670544

pii: 7658894

doi: 10.1093/ije/dyae059

pii:

doi:

Substances chimiques

Copper 789U1901C5

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Associazione Italiana per la Ricerca sul Cancro

ID : 21378

Organisme : Unidade de Investigação em Epidemiologia-Instituto de Saúde Pública da Universidade do Porto

ID : UIDB/04750/2020

Organisme : Foundation for Science and Technology-FCT

Organisme : Portuguese Ministry of Science, Technology and Higher Education

Organisme : Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional

ID : LA/P/0064/2020

Organisme : EPIUnit-Junior Research-Prog Financing

Organisme : Italian Ministry of Health