Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.

Humans Liver Diseases, Alcoholic / metabolism Disease Progression Animals Liver / metabolism Hepatic Stellate Cells / metabolism Epigenesis, Genetic
MetAld alcohol-associated liver disease cell death epigenetics fatty acid binding protein 4 fibrosis hemolysis hepatic stellate cells hepatocellular carcinoma models

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
27 Mar 2024
Historique:
received: 22 02 2024
revised: 20 03 2024
accepted: 24 03 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 27 4 2024
Statut: epublish

Résumé

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.

Identifiants

DOI: 10.3390/biom14040404 PMID: 38672422
pubmed: 38672422
pii: biom14040404
doi: 10.3390/biom14040404
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Natalia A Osna (NA)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA.
ORCID: 0000-0001-7498-0556

Irina Tikhanovich (I)

Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Martí Ortega-Ribera (M)

Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-8647-7069

Sebastian Mueller (S)

Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.
Viscera AG Bauchmedizin, 83011 Bern, Switzerland.
ORCID: 0000-0001-5655-6778

Chaowen Zheng (C)

Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.

Johannes Mueller (J)

Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.

Siyuan Li (S)

Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany.

Sadatsugu Sakane (S)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0002-6306-4621

Raquel Carvalho Gontijo Weber (RCG)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Hyun Young Kim (HY)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Wonseok Lee (W)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Souradipta Ganguly (S)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Yusuke Kimura (Y)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Xiao Liu (X)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Debanjan Dhar (D)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0001-8739-3684

Karin Diggle (K)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

David A Brenner (DA)

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

Tatiana Kisseleva (T)

Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA.

Neha Attal (N)

Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.

Iain H McKillop (IH)

Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA.
ORCID: 0000-0003-2666-6727

Shilpa Chokshi (S)

The Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE59NT, UK.
School of Microbial Sciences, King's College, London SE59NT, UK.

Ram Mahato (R)

Department of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA.
ORCID: 0000-0003-3588-0434

Karuna Rasineni (K)

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68106, USA.
ORCID: 0000-0002-9581-3957

Gyongyi Szabo (G)

Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Kusum K Kharbanda (KK)

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA.
ORCID: 0000-0001-7759-8889

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › Troubles dus à des produits chimiques › Troubles dus à l'abus d'alcool › Maladies alcooliques du foie › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › Eucaryotes › Animaux › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › Système digestif › Foie › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › Alcohol-Associated Liver Disease Outcomes:...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Alcohol-Associated Liver Disease Outcomes:...