The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood-Brain Barrier Dysfunction.

Humans Microglia / metabolism White Matter / metabolism Transcriptome Blood-Brain Barrier / metabolism Male Female Aging / genetics Aged Gene Expression Profiling / methods Aged, 80 and over Neuroprotection / genetics Antigens, Differentiation, Myelomonocytic / metabolism Antigens, CD / metabolism
deep subcortical lesions microglia transcriptomic profiling

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
18 Apr 2024
Historique:
received: 22 02 2024
revised: 12 04 2024
accepted: 16 04 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 27 4 2024
Statut: epublish

Résumé

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68

Identifiants

DOI: 10.3390/ijms25084445 PMID: 38674030
pubmed: 38674030
pii: ijms25084445
doi: 10.3390/ijms25084445
pii:
doi:

Substances chimiques

Antigens, Differentiation, Myelomonocytic 0
Antigens, CD 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : King Abdulaziz University
ID : PhD studentship

Auteurs

Taghreed Almansouri (T)

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Rachel Waller (R)

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
ORCID: 0000-0001-5815-8829

Stephen B Wharton (SB)

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
ORCID: 0000-0003-2785-333X

Paul R Heath (PR)

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
ORCID: 0000-0002-8385-1438

Fiona E Matthews (FE)

Institute for Clinical and Applied Health Research, University of Hull, Hull HU6 7RX, UK.
ORCID: 0000-0002-1728-2388

Carol Brayne (C)

Department of Psychiatry, University of Cambridge, Cambridge CB2 3EG, UK.

Fredericus van Eeden (F)

School of Biosciences, University of Sheffield, Sheffield S10 2GF, UK.

Julie E Simpson (JE)

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
ORCID: 0000-0002-3753-4271

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Cellules › Névroglie › Microglie › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › The Microglial Transcriptome of Age-Associated...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › The Microglial Transcriptome of Age-Associated...