NF-κB in the Radiation Response of A549 Non-Small Cell Lung Cancer Cells to X-rays and Carbon Ions under Hypoxia.
Humans
NF-kappa B
/ metabolism
A549 Cells
Carcinoma, Non-Small-Cell Lung
/ metabolism
Lung Neoplasms
/ metabolism
X-Rays
Gene Expression Regulation, Neoplastic
/ radiation effects
Linear Energy Transfer
Cell Hypoxia
/ radiation effects
Carbon
Cell Survival
/ radiation effects
Radiation Tolerance
Interleukin-8
/ metabolism
12C ions
A549
IL-6/IL-8 secretion
NF-κB
high-LET radiation
hypoxia-induced radioresistance
p65 (RelA) nuclear localization
tumor hypoxia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Apr 2024
19 Apr 2024
Historique:
received:
04
03
2024
revised:
08
04
2024
accepted:
17
04
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
epublish
Résumé
Cellular hypoxia, detectable in up to 80% of non-small cell lung carcinoma (NSCLC) tumors, is a known cause of radioresistance. High linear energy transfer (LET) particle radiation might be effective in the treatment of hypoxic solid tumors, including NSCLC. Cellular hypoxia can activate nuclear factor κB (NF-κB), which can modulate radioresistance by influencing cancer cell survival. The effect of high-LET radiation on NF-κB activation in hypoxic NSCLC cells is unclear. Therefore, we compared the effect of low (X-rays)- and high (
Identifiants
pubmed: 38674080
pii: ijms25084495
doi: 10.3390/ijms25084495
pii:
doi:
Substances chimiques
NF-kappa B
0
Carbon
7440-44-0
Interleukin-8
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Higher Education Commission
ID : 91716300
Organisme : DLR
ID : FuW 475 Radiation & Hypoxia
Organisme : European Union
ID : 262010
Organisme : European Union
ID : 54002
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.