Identification of Key Genes and Imbalanced SNAREs Assembly in the Comorbidity of Polycystic Ovary Syndrome and Depression.
Polycystic Ovary Syndrome
/ genetics
Humans
Female
Depression
/ genetics
Protein Interaction Maps
/ genetics
Qb-SNARE Proteins
/ genetics
Comorbidity
Qc-SNARE Proteins
/ genetics
Polymorphism, Single Nucleotide
SNARE Proteins
/ genetics
Computational Biology
/ methods
Genetic Predisposition to Disease
SNAREs
comorbidity
depression
polycystic ovary syndrome (PCOS)
single nucleotide polymorphisms (SNPs)
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
15 Apr 2024
15 Apr 2024
Historique:
received:
08
02
2024
revised:
02
04
2024
accepted:
11
04
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
epublish
Résumé
Women with polycystic ovary syndrome (PCOS) have increased odds of concurrent depression, indicating that the relationship between PCOS and depression is more likely to be comorbid. However, the underlying mechanism remains unclear. Here, we aimed to use bioinformatic analysis to screen for the genetic elements shared between PCOS and depression. Differentially expressed genes (DEGs) were screened out through GEO2R using the PCOS and depression datasets in NCBI. Protein-protein interaction (PPI) network analysis and enrichment analysis were performed to identify the potential hub genes. After verification using other PCOS and depression datasets, the associations between key gene polymorphism and comorbidity were further studied using data from the UK biobank (UKB) database. In this study, three key genes, namely, Our study suggests that the
Sections du résumé
BACKGROUND
BACKGROUND
Women with polycystic ovary syndrome (PCOS) have increased odds of concurrent depression, indicating that the relationship between PCOS and depression is more likely to be comorbid. However, the underlying mechanism remains unclear. Here, we aimed to use bioinformatic analysis to screen for the genetic elements shared between PCOS and depression.
METHODS
METHODS
Differentially expressed genes (DEGs) were screened out through GEO2R using the PCOS and depression datasets in NCBI. Protein-protein interaction (PPI) network analysis and enrichment analysis were performed to identify the potential hub genes. After verification using other PCOS and depression datasets, the associations between key gene polymorphism and comorbidity were further studied using data from the UK biobank (UKB) database.
RESULTS
RESULTS
In this study, three key genes, namely,
CONCLUSIONS
CONCLUSIONS
Our study suggests that the
Identifiants
pubmed: 38674428
pii: genes15040494
doi: 10.3390/genes15040494
pii:
doi:
Substances chimiques
Qb-SNARE Proteins
0
Qc-SNARE Proteins
0
SNARE Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Shandong Province Medical and Health Technology Development Fund
ID : 202102021141