Exploring Microbial Metabolite Receptors in Inflammatory Bowel Disease: An In Silico Analysis of Their Potential Role in Inflammation and Fibrosis.
inflammation
inflammatory bowel disease
metabolite receptors
metabolites
microbiota
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
12 Apr 2024
12 Apr 2024
Historique:
received:
06
03
2024
revised:
09
04
2024
accepted:
10
04
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
epublish
Résumé
Metabolites produced by dysbiotic intestinal microbiota can influence disease pathophysiology by participating in ligand-receptor interactions. Our aim was to investigate the differential expression of metabolite receptor (MR) genes between inflammatory bowel disease (IBD), healthy individuals (HIs), and disease controls in order to identify possible interactions with inflammatory and fibrotic pathways in the intestine. RNA-sequencing datasets containing 643 Crohn's disease (CD) patients, 467 ulcerative colitis (UC) patients and 295 HIs, and 4
Identifiants
pubmed: 38675452
pii: ph17040492
doi: 10.3390/ph17040492
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Establishment of a Center of Excellence for Pharmacological Studies and Precision Medicine - IMPReS" (MIS 5047189) which is implemented under the Action "Support for Regional Excellence", funded by the Operational Program "Competitiveness, Entrepreneurshi
ID : MIS 5047189