Natural Killer Cells Do Not Attenuate a Mouse-Adapted SARS-CoV-2-Induced Disease in

Animals Killer Cells, Natural / immunology COVID-19 / immunology Mice SARS-CoV-2 / immunology Disease Models, Animal Mice, Inbred C57BL DNA-Binding Proteins / genetics Mice, Knockout Humans Lung / pathology Angiotensin-Converting Enzyme 2 / genetics B-Lymphocytes / immunology Female T-Lymphocytes / immunology
B cells COVID-19 MA30 NK cells SARS-CoV-2 T cells

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
15 Apr 2024
Historique:
received: 25 01 2024
revised: 09 04 2024
accepted: 10 04 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 27 4 2024
Statut: epublish

Résumé

This study investigates the roles of T, B, and Natural Killer (NK) cells in the pathogenesis of severe COVID-19, utilizing mouse-adapted SARS-CoV-2-MA30 (MA30). To evaluate this MA30 mouse model, we characterized MA30-infected C57BL/6 mice (B6) and compared them with SARS-CoV-2-WA1 (an original SARS-CoV-2 strain) infected K18-human ACE2 (

Identifiants

DOI: 10.3390/v16040611 PMID: 38675952
pubmed: 38675952
pii: v16040611
doi: 10.3390/v16040611
pii:
doi:

Substances chimiques

Rag2 protein, mouse 0
DNA-Binding Proteins 0
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : NIH 2 P51OD011104-62
Pays : United States
Organisme : NIH HHS
ID : R01DK129881
Pays : United States
Organisme : NIH HHS
ID : R01HL165265
Pays : United States
Organisme : NIH HHS
ID : R35 HL139930
Pays : United States

Auteurs

Calder R Ellsworth (CR)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0001-7111-525X

Chenxiao Wang (C)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0001-7950-9288

Alexis R Katz (AR)

Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0002-3302-0759

Zheng Chen (Z)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Mohammad Islamuddin (M)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Haoran Yang (H)

Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Sarah E Scheuermann (SE)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
ORCID: 0000-0002-9899-997X

Kelly A Goff (KA)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.

Nicholas J Maness (NJ)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0002-9332-7891

Robert V Blair (RV)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
ORCID: 0000-0001-9616-9414

Jay K Kolls (JK)

Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0001-5151-6304

Xuebin Qin (X)

Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
ORCID: 0000-0001-9875-983X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Appareil respiratoire › Poumon › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Natural Killer Cells Do Not Attenuate a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Natural Killer Cells Do Not Attenuate a...