Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis.
age
dementia
dementia risk reduction
education
effect modification
ethnicity
individual participant data meta‐analysis
interaction
lifestyle
primary prevention
region
risk factor
risk personalization
sex
socioeconomic
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
27 Apr 2024
27 Apr 2024
Historique:
revised:
19
03
2024
received:
14
09
2023
accepted:
19
03
2024
medline:
27
4
2024
pubmed:
27
4
2024
entrez:
27
4
2024
Statut:
aheadofprint
Résumé
The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
Types de publication
English Abstract
Journal Article
Langues
ita
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : AG03949
Pays : United States
Organisme : NIH HHS
ID : RF1AG057531
Pays : United States
Organisme : NIH HHS
ID : AG03949
Pays : United States
Organisme : NIH HHS
ID : R37AG02365
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Alzheimer's Association
ID : IIRG-09-133014
Pays : United States
Organisme : Alzheimer's Association
ID : 189 10276/8/9/2011
Pays : United States
Informations de copyright
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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