Experimental Multi-Parametric MRI Characterization of Iliocaval Venous Thrombosis Pathological Changes.

Iliocaval thrombotic obstruction is a challenging condition, especially since thrombus age and corresponding pathological remodeling at presentation are unknown, which directly impacts management. Our aim was to assess the ability of Magnetic Resonance Imaging (MRI) in determining age thresholds of experimentally created inferior vena cava (IVC) thrombosis in pigs. We used a previously described swine model of IVC thrombosis. Animals underwent MRI at baseline, immediately after thrombosis creation and after a follow-up period extending from 2 to 28 days. Thirteen animals were divided into 3 groups according to disease's chronicity: acute (AG, N Kruskal-Wallis showed a statistically significant difference in T This study highlighted MRI characteristics in a swine model that may have the potential to significantly differentiate a subacute and a chronic stage from an acute stage of deep venous thrombosis in humans. Further clinical studies in humans are warranted.

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