Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway.

Blood-borne infections Chronic kidney failure Epidemiology Sepsis Sepsis epidemiology

Journal

Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307

Informations de publication

Date de publication:
29 Apr 2024
Historique:
received: 05 12 2023
accepted: 08 04 2024
medline: 29 4 2024
pubmed: 29 4 2024
entrez: 28 4 2024
Statut: aheadofprint

Résumé

Bloodstream infections (BSI) and sepsis are important causes of hospitalization, loss of health, and death globally. Targetable risk factors need to be identified to improve prevention and treatment. In this study, we aimed to evaluate the association of chronic kidney disease (CKD) and risk of and mortality from BSI and sepsis in the general population during a 22-year period. We conducted a prospective cohort study among participants in the population-based Norwegian HUNT Study, where 68,438 participated. The median follow-up time was 17.4 years. The exposures were estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR) in urine. The outcomes were hazard ratios (HR) of hospital admission or death due to BSI or sepsis. The associations were adjusted for age, sex, diabetes, obesity, systolic blood pressure, smoking status, and cardiovascular disease. Participants with eGFR < 30 ml/min/1.73 In this large population-based cohort study, CKD was clearly associated with an increased risk of BSI and sepsis and related death.

Identifiants

DOI: 10.1007/s15010-024-02265-2 PMID: 38679665
pubmed: 38679665
doi: 10.1007/s15010-024-02265-2
pii: 10.1007/s15010-024-02265-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200–11.
doi: 10.1016/S0140-6736(19)32989-7 pubmed: 31954465 pmcid: 6970225
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801–10.
doi: 10.1001/jama.2016.0287 pubmed: 26903338 pmcid: 4968574
Jawad I, Lukšić I, Rafnsson SB. Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. J Glob Health. 2012;2: 010404.
doi: 10.7189/jogh.01.010404 pubmed: 23198133 pmcid: 3484761
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLoS ONE. 2022;17: e0271263.
doi: 10.1371/journal.pone.0271263 pubmed: 35819970 pmcid: 9275692
Wang HE, Gamboa C, Warnock DG, Muntner P. Chronic kidney disease and risk of death from infection. Am J Nephrol. 2011;34:330–6.
doi: 10.1159/000330673 pubmed: 21860228 pmcid: 3169360
Ishigami J, Grams ME, Chang AR, Carrero JJ, Coresh J, Matsushita K. CKD and risk for hospitalization with infection: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis. 2017;69:752–61.
doi: 10.1053/j.ajkd.2016.09.018 pubmed: 27884474
Dagasso G, Conley J, Steele L, Parfitt EEC, Pasquill K, Laupland KB. Risk of bloodstream infection in patients with renal dysfunction: a population-based cohort study. Epidemiol Infect. 2020;148:e105.
doi: 10.1017/S0950268820001041 pubmed: 32418552 pmcid: 7315465
James MT, Laupland KB, Tonelli M, Manns BJ, Culleton BF, Hemmelgarn BR. Risk of bloodstream infection in patients with chronic kidney disease not treated with dialysis. Arch Intern Med. 2008;168:2333–9.
doi: 10.1001/archinte.168.21.2333 pubmed: 19029498
Dagasso G, Conley J, Parfitt E, Pasquill K, Steele L, Laupland K. Risk factors associated with bloodstream infections in end-stage renal disease patients: a population-based study. Infect Dis (Lond). 2018;50:831–6.
doi: 10.1080/23744235.2018.1500707 pubmed: 30156131
Xu H, Gasparini A, Ishigami J, Mzayen K, Su G, Barany P, et al. eGFR and the risk of community-acquired infections. Clin J Am Soc Nephrol. 2017;12:1399–408.
doi: 10.2215/CJN.00250117 pubmed: 28818849 pmcid: 5586562
Drozd M, Pujades-Rodriguez M, Lillie PJ, Straw S, Morgan AW, Kearney MT, et al. Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study. Lancet Infect Dis. 2021;21:1184–91.
doi: 10.1016/S1473-3099(20)30978-6 pubmed: 33662324 pmcid: 8323124
Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825–30.
doi: 10.7326/0003-4819-158-11-201306040-00007 pubmed: 23732715
Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, et al. Executive summary of the KDIGO 2021 guideline for the management of glomerular diseases. Kidney Int. 2021;100:753–79.
doi: 10.1016/j.kint.2021.05.015 pubmed: 34556300
Hallan H, Romundstad S, Kvenild K, Holmen J. Microalbuminuria in diabetic and hypertensive patients and the general population–consequences of various diagnostic criteria–the Nord-Trøndelag Health Study (HUNT). Scand J Urol Nephrol. 2003;37:151–8.
doi: 10.1080/00365590310008901 pubmed: 12745725
Krokstad S, Langhammer A, Hveem K, Holmen TL, Midthjell K, Stene TR, et al. Cohort profile: the HUNT study. Norway Int J Epidemiol. 2013;42:968–77.
doi: 10.1093/ije/dys095 pubmed: 22879362
Pottel H, Björk J, Rule AD, Ebert N, Eriksen BO, Dubourg L, et al. Cystatin C-based equation to estimate GFR without the inclusion of race and sex. N Engl J Med. 2023;388:333–43.
doi: 10.1056/NEJMoa2203769 pubmed: 36720134
Kasiske BL, Wheeler DC. KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease foreword. Kidney Int Suppl. 2013;3:2.
Romundstad S, Holmen J, Hallan H, Kvenild K, Ellekjaer H. Microalbuminuria and all-cause mortality in treated hypertensive individuals: does sex matter? The Nord-Trøndelag Health Study (HUNT). Norway Circulation. 2003;108:2783–9.
doi: 10.1161/01.CIR.0000103667.27493.32 pubmed: 14623803
Hallan SI, Øvrehus MA, Romundstad S, Rifkin D, Langhammer A, Stevens PE, et al. Long-term trends in the prevalence of chronic kidney disease and the influence of cardiovascular risk factors in Norway. Kidney Int. 2016;90:665–73.
doi: 10.1016/j.kint.2016.04.012 pubmed: 27344204
Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev. 2006;19:788–802.
doi: 10.1128/CMR.00062-05 pubmed: 17041144 pmcid: 1592696
Organization WH. International statistical classification of diseases and related health problems: Tabular list: World Health Organization; 2004.
Iwashyna TJ, Odden A, Rohde J, Bonham C, Kuhn L, Malani P, et al. Identifying patients with severe sepsis using administrative claims: patient-level validation of the angus implementation of the international consensus conference definition of severe sepsis. Med Care. 2014;52:e39-43.
doi: 10.1097/MLR.0b013e318268ac86 pubmed: 23001437 pmcid: 3568444
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–10.
doi: 10.1097/00003246-200107000-00002 pubmed: 11445675
Fleischmann-Struzek C, Thomas-Rüddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, et al. Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLoS ONE. 2018;13:e0198847.
doi: 10.1371/journal.pone.0198847 pubmed: 30059504 pmcid: 6066203
Wilhelms SB, Huss FR, Granath G, Sjöberg F. Assessment of incidence of severe sepsis in Sweden using different ways of abstracting International Classification of Diseases codes: difficulties with methods and interpretation of results. Crit Care Med. 2010;38:1442–9.
doi: 10.1097/CCM.0b013e3181de4406 pubmed: 20400903
Dalrymple LS, Katz R, Kestenbaum B, de Boer IH, Fried L, Sarnak MJ, et al. The risk of infection-related hospitalization with decreased kidney function. Am J Kidney Dis. 2012;59:356–63.
doi: 10.1053/j.ajkd.2011.07.012 pubmed: 21906862
Viasus D, Garcia-Vidal C, Cruzado JM, Adamuz J, Verdaguer R, Manresa F, et al. Epidemiology, clinical features and outcomes of pneumonia in patients with chronic kidney disease. Nephrol Dial Transplant. 2011;26:2899–906.
doi: 10.1093/ndt/gfq798 pubmed: 21273232
Foley RN. Infections in patients with chronic kidney disease. Infect Dis Clin North Am. 2007;21:659–72, viii.
doi: 10.1016/j.idc.2007.06.005 pubmed: 17826617
Berman SJ, Johnson EW, Nakatsu C, Alkan M, Chen R, LeDuc J. Burden of infection in patients with end-stage renal disease requiring long-term dialysis. Clin Infect Dis. 2004;39:1747–53.
doi: 10.1086/424516 pubmed: 15578394
Ishani A, Collins AJ, Herzog CA, Foley RN. Septicemia, access and cardiovascular disease in dialysis patients: the USRDS wave 2 study1. Kidney Int. 2005;68:311–8.
doi: 10.1111/j.1523-1755.2005.00414.x pubmed: 15954922
Hsu CY, Ordoñez JD, Chertow GM, Fan D, McCulloch CE, Go AS. The risk of acute renal failure in patients with chronic kidney disease. Kidney Int. 2008;74:101–7.
doi: 10.1038/ki.2008.107 pubmed: 18385668 pmcid: 2673528
Fiore E, Tyne DV, Gilmore MS. Pathogenicity of enterococci. Microb Spectr. 2019. https://doi.org/10.1128/microbiolspec.gpp3-0053-2018 .
doi: 10.1128/microbiolspec.gpp3-0053-2018
Girndt M, Sester U, Sester M, Kaul H, Köhler H. Impaired cellular immune function in patients with end-stage renal failure. Nephrol Dial Transplant. 1999;14:2807–10.
doi: 10.1093/ndt/14.12.2807 pubmed: 10570074
Garimella PS, Bartz TM, Ix JH, Chonchol M, Shlipak MG, Devarajan P, et al. Urinary uromodulin and risk of urinary tract infections: the cardiovascular health study. Am J Kidney Dis. 2017;69:744–51.
doi: 10.1053/j.ajkd.2016.08.022 pubmed: 28029393
LaFavers KA, Hage CA, Gaur V, Micanovic R, Hato T, Khan S, et al. The kidney protects against sepsis by producing systemic uromodulin. Am J Physiol Renal Physiol. 2022;323:F212–26.
doi: 10.1152/ajprenal.00146.2022 pubmed: 35759740 pmcid: 9359648
Weiss GL, Stanisich JJ, Sauer MM, Lin CW, Eras J, Zyla DS, et al. Architecture and function of human uromodulin filaments in urinary tract infections. Science. 2020;369:1005–10.
doi: 10.1126/science.aaz9866 pubmed: 32616672
Matsushita K, Coresh J, Sang Y, Chalmers J, Fox C, Guallar E, et al. Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2015;3:514–25.
doi: 10.1016/S2213-8587(15)00040-6 pubmed: 26028594 pmcid: 4594193
Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, et al. Albuminuria increases the risks for both alzheimer disease and vascular dementia in community-dwelling japanese elderly: the Hisayama study. J Am Heart Assoc. 2018. https://doi.org/10.1161/JAHA.117.006693 .
doi: 10.1161/JAHA.117.006693 pubmed: 29353232 pmcid: 5850144
Romundstad S, Naustdal T, Romundstad PR, Sorger H, Langhammer A. COPD and microalbuminuria: a 12-year follow-up study. Eur Respir J. 2014;43:1042–50.
doi: 10.1183/09031936.00160213 pubmed: 24435009
Vincent JL, Ince C, Pickkers P. Endothelial dysfunction: a therapeutic target in bacterial sepsis? Expert Opin Ther Targets. 2021;25:733–48.
doi: 10.1080/14728222.2021.1988928 pubmed: 34602020
Salmon AH, Ferguson JK, Burford JL, Gevorgyan H, Nakano D, Harper SJ, et al. Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction. J Am Soc Nephrol. 2012;23:1339–50.
doi: 10.1681/ASN.2012010017 pubmed: 22797190 pmcid: 3402289
Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway.

Auteurs

Kristin Vardheim Liyanarachi (KV)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. kristin.v.liyanarachi@ntnu.no.
Department of Infectious Diseases, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. kristin.v.liyanarachi@ntnu.no.

Randi Marie Mohus (RM)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Tormod Rogne (T)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Yale Department of Chronic Disease Epidemiology and Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT, USA.

Lise Tuset Gustad (LT)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Faculty of Nursing and Health Sciences, Nord University, Levanger, Norway.
Department of Internal Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.

Bjørn Olav Åsvold (BO)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Department of Public Health and Nursing, HUNT Research Center, NTNU, Norwegian University of Science and Technology, Levanger, Norway.

Solfrid Romundstad (S)

Department of Internal Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Erik Solligård (E)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Helse Møre Og Romsdal Hospital Trust, Ålesund, Norway.

Stein Hallan (S)

Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Nephrology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Jan Kristian Damås (JK)

Mid-Norway Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Infectious Diseases, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

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