Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats.

CO2 Extinction Fear Individual differences Orexin Retrieval-extinction

Journal

Biological psychiatry global open science
ISSN: 2667-1743
Titre abrégé: Biol Psychiatry Glob Open Sci
Pays: United States
ID NLM: 9918227369306676

Informations de publication

Date de publication:
May 2024
Historique:
received: 02 12 2023
revised: 11 02 2024
accepted: 11 03 2024
medline: 29 4 2024
pubmed: 29 4 2024
entrez: 29 4 2024
Statut: epublish

Résumé

Cues present during a traumatic event may result in persistent fear responses. These responses can be attenuated through extinction learning, a core component of exposure therapy. Exposure/extinction is effective for some people, but not all. We recently demonstrated that carbon dioxide (CO Male rats first underwent a CO We found that retrieval-extinction resulted in lower freezing during extinction, LTM, and reinstatement than standard extinction. Using the best subset approach to linear regression, we found that CO CO Extinction learning underlies exposure therapy, a treatment for anxiety disorders. However, not everyone benefits from exposure therapy, highlighting the need in developing approaches that may help predict which individuals will respond. We tested whether extinction or an alternative treatment called retrieval-extinction would be more effective at reducing conditioned fear responses in rats and whether the response to a carbon dioxide (CO

Sections du résumé

Background UNASSIGNED
Cues present during a traumatic event may result in persistent fear responses. These responses can be attenuated through extinction learning, a core component of exposure therapy. Exposure/extinction is effective for some people, but not all. We recently demonstrated that carbon dioxide (CO
Methods UNASSIGNED
Male rats first underwent a CO
Results UNASSIGNED
We found that retrieval-extinction resulted in lower freezing during extinction, LTM, and reinstatement than standard extinction. Using the best subset approach to linear regression, we found that CO
Conclusions UNASSIGNED
CO
Extinction learning underlies exposure therapy, a treatment for anxiety disorders. However, not everyone benefits from exposure therapy, highlighting the need in developing approaches that may help predict which individuals will respond. We tested whether extinction or an alternative treatment called retrieval-extinction would be more effective at reducing conditioned fear responses in rats and whether the response to a carbon dioxide (CO

Autres résumés

Type: plain-language-summary (eng)
Extinction learning underlies exposure therapy, a treatment for anxiety disorders. However, not everyone benefits from exposure therapy, highlighting the need in developing approaches that may help predict which individuals will respond. We tested whether extinction or an alternative treatment called retrieval-extinction would be more effective at reducing conditioned fear responses in rats and whether the response to a carbon dioxide (CO

Identifiants

DOI: 10.1016/j.bpsgos.2024.100310 PMID: 38680941 PMC: PMC11047292
pubmed: 38680941
doi: 10.1016/j.bpsgos.2024.100310
pii: S2667-1743(24)00023-5
pmc: PMC11047292
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100310

Informations de copyright

© 2024 The Authors.

Auteurs

Marissa Raskin (M)

Institute for Neuroscience, University of Texas at Austin, Austin, Texas.

Nicole E Keller (NE)

Institute for Neuroscience, University of Texas at Austin, Austin, Texas.

Laura A Agee (LA)

Department of Neuroscience, University of Texas at Austin, Austin, Texas.

Jason Shumake (J)

Department of Psychology, University of Texas at Austin, Austin, Texas.

Jasper A J Smits (JAJ)

Department of Psychology, University of Texas at Austin, Austin, Texas.

Michael J Telch (MJ)

Department of Psychology, University of Texas at Austin, Austin, Texas.

Michael W Otto (MW)

Department of Psychological & Brain Sciences, Boston University, Boston, Massachusetts.

Hongjoo J Lee (HJ)

Institute for Neuroscience, University of Texas at Austin, Austin, Texas.
Department of Psychology, University of Texas at Austin, Austin, Texas.

Marie-H Monfils (MH)

Institute for Neuroscience, University of Texas at Austin, Austin, Texas.
Department of Psychology, University of Texas at Austin, Austin, Texas.

Classifications MeSH