Glucagon kinetics assessed by mathematical modelling during oral glucose administration in people spanning from normal glucose tolerance to type 2 diabetes.
Humans
Diabetes Mellitus, Type 2
/ blood
Glucagon
/ blood
Glucose Tolerance Test
Male
Female
Middle Aged
Blood Glucose
/ metabolism
Insulin Resistance
Adult
Glucose
/ metabolism
Models, Theoretical
Insulin
/ blood
Aged
Glucagon-Secreting Cells
/ metabolism
Administration, Oral
Kinetics
Glucose Intolerance
/ blood
alpha-cell function
alpha-cell insulin sensitivity
glucagon
glucose homeostasis
insulin
mathematical model
precision medicine
type 2 diabetes
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2024
2024
Historique:
received:
25
01
2024
accepted:
28
03
2024
medline:
29
4
2024
pubmed:
29
4
2024
entrez:
29
4
2024
Statut:
epublish
Résumé
Glucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon variations (especially, glucagon inhibition) to insulin levels ("alpha-cell insulin sensitivity"), during oral glucose administration. We studied 50 participants (spanning from normal glucose tolerance to type 2 diabetes) undergoing frequently sampled 5-hr oral glucose tolerance test (OGTT). The alpha-cell insulin sensitivity and the glucagon kinetics were assessed by a mathematical model that we developed previously. The alpha-cell insulin sensitivity parameter (named S The alpha-cell insulin sensitivity is highly variable among subjects, and it is different in groups at different glucose tolerance. This may be relevant for defining personalized treatment schemes, in terms of dietary prescriptions but also for treatments with glucagon-related agents.
Sections du résumé
Background/Objectives
UNASSIGNED
Glucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon variations (especially, glucagon inhibition) to insulin levels ("alpha-cell insulin sensitivity"), during oral glucose administration.
Subjects/Methods
UNASSIGNED
We studied 50 participants (spanning from normal glucose tolerance to type 2 diabetes) undergoing frequently sampled 5-hr oral glucose tolerance test (OGTT). The alpha-cell insulin sensitivity and the glucagon kinetics were assessed by a mathematical model that we developed previously.
Results
UNASSIGNED
The alpha-cell insulin sensitivity parameter (named S
Conclusions
UNASSIGNED
The alpha-cell insulin sensitivity is highly variable among subjects, and it is different in groups at different glucose tolerance. This may be relevant for defining personalized treatment schemes, in terms of dietary prescriptions but also for treatments with glucagon-related agents.
Identifiants
pubmed: 38681771
doi: 10.3389/fendo.2024.1376530
pmc: PMC11045965
doi:
Substances chimiques
Glucagon
9007-92-5
Blood Glucose
0
Glucose
IY9XDZ35W2
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1376530Informations de copyright
Copyright © 2024 Andreozzi, Mancuso, Rubino, Salvatori, Morettini, Monea, Göbl, Mannino and Tura.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.