Tissue-specific features of innate lymphoid cells in antiviral defense.

NK cell anti-viral immunity innate lymphoid cell tissue microenvironment virus infection

Journal

Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872

Informations de publication

Date de publication:
29 Apr 2024
Historique:
received: 25 12 2023
accepted: 01 04 2024
medline: 30 4 2024
pubmed: 30 4 2024
entrez: 29 4 2024
Statut: aheadofprint

Résumé

Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microenvironment. This review focuses on the specialized functions of each ILC subtype and their roles in antiviral immune responses across tissues. Several viruses within infection-prone tissues will be highlighted to provide an overview of the extent of the ILC immunity within tissues and emphasize common versus virus-specific responses.

Identifiants

pubmed: 38684766
doi: 10.1038/s41423-024-01161-x
pii: 10.1038/s41423-024-01161-x
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Vivier E, Artis D, Colonna M, Diefenbach A, Santo JPD, Eberl G, et al. Innate lymphoid cells: 10 years on. Cell. 2018;174:1054–66.
pubmed: 30142344 doi: 10.1016/j.cell.2018.07.017
Cherrier DE, Serafini N, Santo JPD. Innate lymphoid cell development: A T cell perspective. Immunity. 2018;48:1091–103.
pubmed: 29924975 doi: 10.1016/j.immuni.2018.05.010
Sojka DK, Plougastel-Douglas B, Yang L, Pak-Wittel MA, Artyomov MN, Ivanova Y, et al. Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells. elife. 2014;3:e01659.
pubmed: 24714492 pmcid: 3975579 doi: 10.7554/eLife.01659
Aw-Yeang H-X, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C, et al. Cutting edge: Human CD49e- NK cells are tissue resident in the liver. J Immunol. 2017;198:1417–22.
pubmed: 28093522 doi: 10.4049/jimmunol.1601818
Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, et al. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity. 2012;36:55–67.
pubmed: 22261438 pmcid: 3381976 doi: 10.1016/j.immuni.2011.11.016
Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med. 2014;211:563–77.
pubmed: 24516120 pmcid: 3949572 doi: 10.1084/jem.20131560
Klose CSN, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, et al. Differentiation of Type 1 ILCs from a common progenitor to all Helper-like innate lymphoid cell lineages. Cell. 2014;157:340–56.
pubmed: 24725403 doi: 10.1016/j.cell.2014.03.030
Mackay LK, Minnich M, Kragten NAM, Liao Y, Nota B, Seillet C, et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science. 2016;352:459–63.
pubmed: 27102484 doi: 10.1126/science.aad2035
Friedrich C, Taggenbrock RLRE, Doucet-Ladevèze R, Golda G, Moenius R, Arampatzi P, et al. Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues. Nat Immunol. 2021;22:1256–67.
pubmed: 34462601 pmcid: 7611762 doi: 10.1038/s41590-021-01013-0
Yomogida K, Bigley TM, Trsan T, Gilfillan S, Cella M, Yokoyama WM, et al. Hobit confers tissue-dependent programs to type 1 innate lymphoid cells. Proc Natl Acad Sci. 2021;118:e2117965118.
pubmed: 34880136 pmcid: 8685927 doi: 10.1073/pnas.2117965118
Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TKA, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367–70.
pubmed: 20200518 pmcid: 2862165 doi: 10.1038/nature08900
Moro K, Kabata H, Tanabe M, Koga S, Takeno N, Mochizuki M, et al. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat Immunol. 2016;17:76–86.
pubmed: 26595888 doi: 10.1038/ni.3309
Price AE, Liang H-E, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, et al. Systemically dispersed innate IL-13–expressing cells in type 2 immunity. Proc Natl Acad Sci. 2010;107:11489–94.
pubmed: 20534524 pmcid: 2895098 doi: 10.1073/pnas.1003988107
Hoyler T, Klose CSN, Souabni A, Turqueti-Neves A, Pfeifer D, Rawlins EL, et al. The transcription factor GATA-3 controls cell fate and maintenance of Type 2 innate lymphoid cells. Immunity. 2012;37:634–48.
pubmed: 23063333 pmcid: 3662874 doi: 10.1016/j.immuni.2012.06.020
Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, et al. The transcription factor GATA3 is essential for the function of human Type 2 innate lymphoid cells. Immunity. 2012;37:649–59.
pubmed: 23063330 doi: 10.1016/j.immuni.2012.08.015
Satoh-Takayama N, Vosshenrich CAJ, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives Interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29:958–70.
pubmed: 19084435 doi: 10.1016/j.immuni.2008.11.001
Sanos SL, Bui VL, Mortha A, Oberle K, Heners C, Johner C, et al. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells. Nat Immunol. 2009;10:83–91.
pubmed: 19029903 doi: 10.1038/ni.1684
Luci C, Reynders A, Ivanov II, Cognet C, Chiche L, Chasson L, et al. Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin. Nat Immunol. 2009;10:75–82.
pubmed: 19029904 doi: 10.1038/ni.1681
Cupedo T, Crellin NK, Papazian N, Rombouts EJ, Weijer K, Grogan JL, et al. Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells. Nat Immunol. 2008;10:66–74.
pubmed: 19029905 doi: 10.1038/ni.1668
Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, et al. Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206:35–41.
pubmed: 19114665 pmcid: 2626689 doi: 10.1084/jem.20072713
Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz JKM, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457:722–5.
pubmed: 18978771 doi: 10.1038/nature07537
Spits H, Artis D, Colonna M, Diefenbach A, Santo JPD, Eberl G, et al. Innate lymphoid cells–a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13:145–9.
pubmed: 23348417 doi: 10.1038/nri3365
Mebius RE, Rennert P, Weissman IL. Developing Lymph Nodes Collect CD4+CD3− LTβ+ Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells. Immunity. 1997;7:493–504.
pubmed: 9354470 doi: 10.1016/S1074-7613(00)80371-4
Eberl G, Marmon S, Sunshine M-J, Rennert PD, Choi Y, Littman DR. An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells. Nat Immunol. 2004;5:64–73.
pubmed: 14691482 doi: 10.1038/ni1022
Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK, et al. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol. 2015;16:306–17.
pubmed: 25621825 pmcid: 4372143 doi: 10.1038/ni.3094
Shikhagaie MM, Björklund ÅK, Mjösberg J, Erjefält JS, Cornelissen AS, Ros XR, et al. Neuropilin-1 is expressed on lymphoid tissue residing LTi-like Group 3 innate lymphoid cells and associated with ectopic lymphoid aggregates. Cell Rep. 2017;18:1761–73.
pubmed: 28199847 pmcid: 5318658 doi: 10.1016/j.celrep.2017.01.063
Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. A committed precursor to innate lymphoid cells. Nature. 2014;508:397–401.
pubmed: 24509713 pmcid: 4003507 doi: 10.1038/nature13047
Ishizuka IE, Chea S, Gudjonson H, Constantinides MG, Dinner AR, Bendelac A, et al. Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue–inducer cell lineage. Nat Immunol. 2016;17:269–76.
pubmed: 26779601 pmcid: 4755916 doi: 10.1038/ni.3344
Colonna M. Innate lymphoid cells: diversity, plasticity, and unique functions in immunity. Immunity. 2018;48:1104–17.
pubmed: 29924976 pmcid: 6344351 doi: 10.1016/j.immuni.2018.05.013
Meininger I, Carrasco A, Rao A, Soini T, Kokkinou E, Mjösberg J. Tissue-specific features of innate lymphoid cells. Trends Immunol. 2020;41:902–17.
pubmed: 32917510 doi: 10.1016/j.it.2020.08.009
Spits H, Mjösberg J. Heterogeneity of type 2 innate lymphoid cells. Nat Rev Immunol. 2022;22:701–12.
pubmed: 35354980 pmcid: 8966870 doi: 10.1038/s41577-022-00704-5
Bal SM, Golebski K, Spits H. Plasticity of innate lymphoid cell subsets. Nat Rev Immunol. 2020;136:2348–565.
Jacquelot N, Seillet C, Vivier E, Belz GT. Innate lymphoid cells and cancer. Nat Immunol. 2022;23:371–9.
pubmed: 35228695 doi: 10.1038/s41590-022-01127-z
Korchagina AA, Koroleva E, Tumanov AV. Innate lymphoid cell plasticity in mucosal infections. Microorganisms. 2023;11:461.
pubmed: 36838426 pmcid: 9967737 doi: 10.3390/microorganisms11020461
Riggan L, Freud AG, O’Sullivan TE. True detective: Unraveling Group 1 innate lymphocyte heterogeneity. Trends Immunol. 2019;40:909–21.
pubmed: 31500958 pmcid: 6823149 doi: 10.1016/j.it.2019.08.005
Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, et al. Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nat Immunol. 2017;18:1004–15.
pubmed: 28759001 doi: 10.1038/ni.3800
Park E, Patel S, Wang Q, Andhey P, Zaitsev K, Porter S, et al. Toxoplasma Gondii infection drives conversion of NK cells into ILC1-like cells. elife. 2019;8:41.
doi: 10.7554/eLife.47605
Cella M, Otero K, Colonna M. Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity. Proc Natl Acad Sci USA. 2010;107:10961–6.
pubmed: 20534450 pmcid: 2890739 doi: 10.1073/pnas.1005641107
Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, et al. Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues. Nat Immunol. 2019;20:980–91.
pubmed: 31209406 pmcid: 6685551 doi: 10.1038/s41590-019-0425-y
Gury-BenAri M, Thaiss CA, Serafini N, Winter DR, Giladi A, Lara-Astiaso D, et al. The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome. Cell. 2016;166:1231–.e13.
pubmed: 27545347 doi: 10.1016/j.cell.2016.07.043
Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al. The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing. Nat Immunol. 2016;17:451–60.
pubmed: 26878113 doi: 10.1038/ni.3368
McFarland AP, Yalin A, Wang S-Y, Cortez VS, Landsberger T, Sudan R, et al. Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation. Immunity. 2021;54:1320–.e4.
pubmed: 33945787 pmcid: 8312473 doi: 10.1016/j.immuni.2021.03.024
Crinier A, Milpied P, Escalière B, Piperoglou C, Galluso J, Balsamo A, et al. High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice. Immunity. 2018;49:971–.e5.
pubmed: 30413361 pmcid: 6269138 doi: 10.1016/j.immuni.2018.09.009
Lopes N, Galluso J, Escalière B, Carpentier S, Kerdiles YM, Vivier E. Tissue-specific transcriptional profiles and heterogeneity of natural killer cells and group 1 innate lymphoid cells. Cell Rep. Med. 2022;3:100812.
pubmed: 36384102 pmcid: 9729827 doi: 10.1016/j.xcrm.2022.100812
Mazzurana L, Czarnewski P, Jonsson V, Wigge L, Ringnér M, Williams TC, et al. Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing. Cell Res. 2021;31:554–68.
pubmed: 33420427 pmcid: 8089104 doi: 10.1038/s41422-020-00445-x
Conde CD, Xu C, Jarvis LB, Rainbow DB, Wells SB, Gomes T, et al. Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science. 2022;376:eabl5197–eabl5197.
doi: 10.1126/science.abl5197
Kiessling R, Klein E, Wigzell H. “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol. 1975;5:112–7.
pubmed: 1234049 doi: 10.1002/eji.1830050208
Herberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer. 1975;16:216–29.
pubmed: 50294 doi: 10.1002/ijc.2910160204
Kärre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature. 1986;319:675–8.
pubmed: 3951539 doi: 10.1038/319675a0
Kärre K. Natural killer cell recognition of missing self. Nat Immunol. 2008;9:477–80.
pubmed: 18425103 doi: 10.1038/ni0508-477
Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song Y-J, Yang L, et al. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature. 2005;436:709–13.
pubmed: 16079848 doi: 10.1038/nature03847
Fernandez NC, Treiner E, Vance RE, Jamieson AM, Lemieux S, Raulet DH. A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood. 2005;105:4416–23.
pubmed: 15728129 pmcid: 1895026 doi: 10.1182/blood-2004-08-3156
Holle TAV, Moody MA. Influenza and antibody-dependent cellular cytotoxicity. Front Immunol. 2019;10:1457.
doi: 10.3389/fimmu.2019.01457
Forthal DN, Finzi A. Antibody-dependent cellular cytotoxicity in HIV infection. AIDS. 2018;32:2439–51.
pubmed: 30234611 doi: 10.1097/QAD.0000000000002011
Piersma SJ, Brizić I. Natural killer cell effector functions in antiviral defense. FEBS J 2021. https://doi.org/10.1111/febs.16073 .
Waggoner SN, Cornberg M, Selin LK, Welsh RM. Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2011;481:394–8.
pubmed: 22101430 pmcid: 3539796 doi: 10.1038/nature10624
Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M, et al. TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity. Immunity. 2014;41:646–56.
pubmed: 25367576 doi: 10.1016/j.immuni.2014.09.013
Bukowski JF, Woda BA, Habu S, Okumura K, Welsh RM. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J Immunol. 1983;131:1531–8.
pubmed: 6309965 doi: 10.4049/jimmunol.131.3.1531
Scalzo A, FITZGERALD N, WALLACE C, GIBBONS A, SMART Y, BURTON R, et al. The effect of the Cmv-1 resistance gene, which is linked to the natural-killer-cell gene-complex, is mediated by natural-killer-cells. J Immunol. 1992;149:581–9.
pubmed: 1378069 doi: 10.4049/jimmunol.149.2.581
Brown MG, Dokun AO, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 2001;292:934–7.
pubmed: 11340207 doi: 10.1126/science.1060042
Lee SH, Girard S, Macina D, Busà M, Zafer A, Belouchi A, et al. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet. 2001;28:42–45.
pubmed: 11326273 doi: 10.1038/ng0501-42
Smith HRC, Heusel JW, Mehta IK, Kim S, Dorner BG, Naidenko OV, et al. Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci USA. 2002;99:8826–31.
pubmed: 12060703 pmcid: 124383 doi: 10.1073/pnas.092258599
Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 2002;296:1323–6.
pubmed: 11950999 doi: 10.1126/science.1070884
Babić M, Pyzik M, Zafirova B, Mitrović M, Butorac V, Lanier LL, et al. Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. J Exp Med. 2010;207:2663–73.
pubmed: 21078887 pmcid: 2989764 doi: 10.1084/jem.20100921
Parikh BA, Bern MD, Piersma SJ, Yang L, Beckman DL, Poursine-Laurent J, et al. Control of viral infection by natural killer cell inhibitory receptors. Cell Rep. 2020;32:107969.
pubmed: 32726632 pmcid: 7458139 doi: 10.1016/j.celrep.2020.107969
Gamache A, Cronk JM, Nash WT, Puchalski P, Gillespie A, Wei H, et al. Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection. Proc Natl Acad Sci USA. 2019;1:201913064.
Orange JS, Wang B, Terhorst C, Biron CA. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J Exp Med. 1995;182:1045–56.
pubmed: 7561678 doi: 10.1084/jem.182.4.1045
Loh J, Chu DT, O’Guin AK, Yokoyama WM, Virgin HW. Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver. J Virol. 2005;79:661–7.
pubmed: 15596864 pmcid: 538682 doi: 10.1128/JVI.79.1.661-667.2005
Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, et al. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity. 2007;26:798–811.
pubmed: 17540585 doi: 10.1016/j.immuni.2007.04.010
Parikh BA, Piersma SJ, Pak-Wittel MA, Yang L, Schreiber RD, Yokoyama WM. Dual requirement of cytokine and activation receptor triggering for cytotoxic control of murine Cytomegalovirus by NK cells. PLoS Pathog. 2015;11:e1005323.
pubmed: 26720279 pmcid: 4697817 doi: 10.1371/journal.ppat.1005323
Dokun AO, Kim S, Smith H, Kang H, Chu D, Yokoyama WM. Specific and nonspecific NK cell activation during virus infection. Nat Immunol. 2001;2:951–6.
pubmed: 11550009 doi: 10.1038/ni714
Sun JC, Beilke JN, Lanier LL. Adaptive immune features of natural killer cells. Nature. 2009;457:557–61.
pubmed: 19136945 pmcid: 2674434 doi: 10.1038/nature07665
Flommersfeld S, Böttcher JP, Ersching J, Flossdorf M, Meiser P, Pachmayr LO, et al. Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity. 2021;54:2288–.e7.
pubmed: 34437840 pmcid: 8528403 doi: 10.1016/j.immuni.2021.08.002
Mujal AM, Delconte RB, Sun JC. Natural killer cells: from innate to adaptive features. Annu Rev Immunol. 2021;39:417–47.
pubmed: 33902312 doi: 10.1146/annurev-immunol-101819-074948
Gumá M, Angulo A, Vilches C, Gómez-Lozano N, Malats N, Lopez-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood. 2004;104:3664–71.
pubmed: 15304389 doi: 10.1182/blood-2004-05-2058
Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, et al. Expansion of a unique CD57
pubmed: 21825173 pmcid: 3169160 doi: 10.1073/pnas.1110900108
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, et al. Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity. 2015;42:443–56.
pubmed: 25786176 pmcid: 4612277 doi: 10.1016/j.immuni.2015.02.008
Lee J, Zhang T, Hwang I, Kim A, Nitschke L, Kim M, et al. Epigenetic modification and antibody-dependent expansion of memory-like NK Cells in human cytomegalovirus-infected individuals. Immunity. 2015;42:431–42.
pubmed: 25786175 pmcid: 4537797 doi: 10.1016/j.immuni.2015.02.013
Martin MP, Carrington M. Immunogenetics of HIV disease. Immunol Rev. 2013;254:245–64.
pubmed: 23772624 pmcid: 3703621 doi: 10.1111/imr.12071
Martin MP, Gao X, Lee J-H, Nelson GW, Detels R, Goedert JJ, et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002;31:429–34.
pubmed: 12134147 doi: 10.1038/ng934
Qi Y, Martin MP, Gao X, Jacobson L, Goedert JJ, Buchbinder S, et al. KIR/HLA pleiotropism: protection against both HIV and opportunistic infections. PLoS Pathog. 2006;2:e79.
pubmed: 16933987 pmcid: 1550271 doi: 10.1371/journal.ppat.0020079
Alter G, Rihn S, Walter K, Nolting A, Martin M, Rosenberg ES, et al. HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection. J Virol. 2009;83:6798–805.
pubmed: 19386717 pmcid: 2698561 doi: 10.1128/JVI.00256-09
Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, et al. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med. 2007;204:3027–36.
pubmed: 18025129 pmcid: 2118524 doi: 10.1084/jem.20070695
Sungur CM, Wang Q, Ozantürk AN, Gao H, Schmitz AJ, Cella M, et al. Human natural killer cells confer protection against HIV-1 infection in humanized mice. J Clin Investig. 2022;132:e162694.
pubmed: 36282589 pmcid: 9753998 doi: 10.1172/JCI162694
Biron CA, Byron KS, Sullivan JL. Severe herpesvirus infections in an adolescent without natural killer cells. N. Engl J Med. 1989;320:1731–5.
pubmed: 2543925 doi: 10.1056/NEJM198906293202605
Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev. 2019;287:202–25.
pubmed: 30565241 pmcid: 6310041 doi: 10.1111/imr.12725
Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, et al. Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Investig. 2016;127:306–20.
pubmed: 27893462 pmcid: 5199714 doi: 10.1172/JCI86276
Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, et al. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014;123:809–21.
pubmed: 24227816 pmcid: 3916876 doi: 10.1182/blood-2013-07-515528
Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, et al. Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest. 2012;122:821–32.
pubmed: 22354167 pmcid: 3287233 doi: 10.1172/JCI61014
Cottineau J, Kottemann MC, Lach FP, Kang Y-H, Vély F, Deenick EK, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991–2006.
pubmed: 28414293 pmcid: 5409070 doi: 10.1172/JCI90727
Mace EM, Paust S, Conte MI, Baxley RM, Schmit MM, Patil SL, et al. Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020;130:5272–86.
pubmed: 32865517 pmcid: 7524476 doi: 10.1172/JCI134966
Hanna S, Béziat V, Jouanguy E, Casanova JL, Etzioni A. A homozygous mutation of RTEL1 in a child presenting with an apparently isolated natural killer cell deficiency. J Allergy Clin Immun. 2015;136:1113–4.
pubmed: 26025130 doi: 10.1016/j.jaci.2015.04.021
Grier JT, Forbes LR, Monaco-Shawver L, Oshinsky J, Atkinson TP, Moody C, et al. Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. J Clin Invest. 2012;122:3769–80.
pubmed: 23006327 pmcid: 3461929 doi: 10.1172/JCI64837
Alinger JB, Mace EM, Porter JR, Mah-Som AY, Daugherty AL, Li S et al. Human PLCG2 haploinsufficiency results in a novel natural killer cell immunodeficiency. J Allergy Clin Immunol 2023. https://doi.org/10.1016/j.jaci.2023.09.002 .
Lanier LL. Evolutionary struggles between NK cells and viruses. Nat Rev Immunol. 2008;8:259–68.
pubmed: 18340344 pmcid: 2584366 doi: 10.1038/nri2276
Hammer Q, Rückert T, Romagnani C. Natural killer cell specificity for viral infections. Nat Immunol. 2018;19:800–8.
pubmed: 30026479 doi: 10.1038/s41590-018-0163-6
Berry R, Watson GM, Jonjic S, Degli-Esposti MA, Rossjohn J. Modulation of innate and adaptive immunity by cytomegaloviruses. Nat Rev Immunol. 2020;20:113–27.
pubmed: 31666730 doi: 10.1038/s41577-019-0225-5
Beck S, Barrell BG. Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature. 1988;331:269–72.
pubmed: 2827039 doi: 10.1038/331269a0
Kim Y, Park B, Cho S, Shin J, Cho K, Jun Y, et al. Human Cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses. PLoS Pathog. 2008;4:e1000123.
pubmed: 18688275 pmcid: 2483941 doi: 10.1371/journal.ppat.1000123
Corbett AJ, Coudert JD, Forbes CA, Scalzo AA. Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation. J Immunol. 2011;186:1713–22.
pubmed: 21187440 doi: 10.4049/jimmunol.1003308
Wang X, Piersma SJ, Nelson CA, Dai Y-N, Christensen T, Lazear E, et al. A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement. elife. 2018;7:15.
doi: 10.7554/eLife.38667
Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood. 2001;97:3146–51.
pubmed: 11342442 doi: 10.1182/blood.V97.10.3146
Jacobs R, Hintzen G, Kemper A, Beul K, Kempf S, Behrens G, et al. CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells. Eur J Immunol. 2001;31:3121–6.
pubmed: 11592089 doi: 10.1002/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4
Kim S, Iizuka K, Kang H, Dokun AO, French AR, Greco S, et al. In vivo developmental stages in murine natural killer cell maturation. Nat Immunol. 2002;3:523–8.
pubmed: 12006976 doi: 10.1038/ni796
Hayakawa Y, Smyth MJ. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol. 2006;176:1517–24.
pubmed: 16424180 doi: 10.4049/jimmunol.176.3.1517
Peng H, Jiang X, Chen Y, Sojka DK, Wei H, Gao X, et al. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013;123:1444–56.
pubmed: 23524967 pmcid: 3613925 doi: 10.1172/JCI66381
Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 2015;350:981–5.
pubmed: 26472762 pmcid: 4720139 doi: 10.1126/science.aac9593
Yudanin NA, Schmitz F, Flamar A-L, Thome JJC, Wojno ET, Moeller JB, et al. Spatial and temporal mapping of human innate lymphoid cells reveals elements of tissue specificity. Immunity. 2019;50:505–.e4.
pubmed: 30770247 pmcid: 6594374 doi: 10.1016/j.immuni.2019.01.012
Dogra P, Rancan C, Ma W, Toth M, Senda T, Carpenter DJ, et al. Tissue determinants of human NK cell development, function, and residence. Cell. 2020;180:749–.e13.
pubmed: 32059780 pmcid: 7194029 doi: 10.1016/j.cell.2020.01.022
Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo S-L, Loh CY, et al. Human innate lymphoid cell subsets possess tissue-type-based heterogeneity in phenotype and frequency. Immunity. 2017;46:148–61.
pubmed: 27986455 doi: 10.1016/j.immuni.2016.11.005
Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL, et al. Transforming Growth Factor-β signaling guides the differentiation of innate lymphoid cells in salivary glands. Immunity. 2016;44:1127–39.
pubmed: 27156386 pmcid: 5114145 doi: 10.1016/j.immuni.2016.03.007
Vosshenrich CAJ, García-Ojeda ME, Samson-Villéger SI, Pasqualetto V, Enault L, Goff OR-L, et al. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol. 2006;7:1217–24.
pubmed: 17013389 doi: 10.1038/ni1395
Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodström-Tullberg M, et al. Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice. J Immunol. 2010;184:2272–80.
pubmed: 20130214 doi: 10.4049/jimmunol.0804358
Fuchs A, Vermi W, Lee JS, Lonardi S, Gilfillan S, Newberry RD, et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity. 2013;38:769–81.
pubmed: 23453631 pmcid: 3634355 doi: 10.1016/j.immuni.2013.02.010
Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000–9. https://doi.org/10.1038/ni.2395 .
doi: 10.1038/ni.2395 pubmed: 22902830 pmcid: 3572860
Weizman O-E, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, et al. ILC1 confer early host protection at initial sites of viral infection. Cell. 2017;171:795–808.e12.
pubmed: 29056343 pmcid: 5687850 doi: 10.1016/j.cell.2017.09.052
Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, et al. Cancer Immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell. 2016;164:365–77.
pubmed: 26806130 pmcid: 4733424 doi: 10.1016/j.cell.2016.01.002
Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, et al. Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 2022;23:904–15.
pubmed: 35618834 pmcid: 9202504 doi: 10.1038/s41590-022-01213-2
Cenerenti M, Saillard M, Romero P, Jandus C. The era of cytotoxic CD4 T cells. Front Immunol. 2022;13:867189.
pubmed: 35572552 pmcid: 9094409 doi: 10.3389/fimmu.2022.867189
Verma S, Loewendorf A, Wang Q, McDonald B, Redwood A, Benedict CA. Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense. PLoS Pathog. 2014;10:e1004268.
pubmed: 25122141 pmcid: 4133390 doi: 10.1371/journal.ppat.1004268
Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, Morabiti RE, et al. Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses. J Virol. 2019;93:e00617–19.
pubmed: 31142671 pmcid: 6675903 doi: 10.1128/JVI.00617-19
Krämer B, Nalin AP, Ma F, Eickhoff S, Lutz P, Leonardelli S, et al. Single-cell RNA sequencing identifies a population of human liver-type ILC1s. Cell Rep. 2023;42:111937.
pubmed: 36640314 pmcid: 9950534 doi: 10.1016/j.celrep.2022.111937
Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature. 2010;463:540–4.
pubmed: 20023630 doi: 10.1038/nature08636
Seehus CR, Kadavallore A, Torre Bdela, Yeckes AR, Wang Y, Tang J, et al. Alternative activation generates IL-10 producing type 2 innate lymphoid cells. Nat Commun. 2017;8:1900.
pubmed: 29196657 pmcid: 5711851 doi: 10.1038/s41467-017-02023-z
Ploeg, van der EK, Golebski, Nimwegen K, van M, Fergusson JR, et al. Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases. Sci Immunol. 2021;6:eabd3489.
pubmed: 33514640 doi: 10.1126/sciimmunol.abd3489
Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U, et al. IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential “inflammatory” type 2 innate lymphoid cells. Nat Immunol. 2014;16:161–9.
pubmed: 25531830 pmcid: 4297567 doi: 10.1038/ni.3078
Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CGK, Doering TA, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12:1045–54.
pubmed: 21946417 pmcid: 3320042 doi: 10.1038/ni.2131
Monticelli LA, Osborne LC, Noti M, Tran SV, Zaiss DMW, Artis D. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions. Proc Natl Acad Sci. 2015;112:10762–7.
pubmed: 26243875 pmcid: 4553775 doi: 10.1073/pnas.1509070112
Mjösberg, Trifari JM, Crellin S, Peters NK, Drunen CP, van CM, et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011;12:1055–62.
pubmed: 21909091 doi: 10.1038/ni.2104
Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015;519:242–6.
pubmed: 25533952 doi: 10.1038/nature14115
Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, et al. Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nat Immunol. 2016;17:626–35.
pubmed: 27111143 pmcid: 5345745 doi: 10.1038/ni.3443
Moral JA, Leung J, Rojas LA, Ruan J, Zhao J, Sethna Z, et al. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature. 2020;579:130–5.
pubmed: 32076273 pmcid: 7060130 doi: 10.1038/s41586-020-2015-4
Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang H-E, Locksley RM. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. J Exp Med. 2020;217:e20191172.
pubmed: 32031571 pmcid: 7144525 doi: 10.1084/jem.20191172
Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012;336:1321–5.
pubmed: 22674331 pmcid: 3659421 doi: 10.1126/science.1222551
Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14:282–9.
pubmed: 18264109 doi: 10.1038/nm1720
Sonnenberg GF, Monticelli LA, Elloso MM, Fouser LA, Artis D. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2011;34:122–34.
pubmed: 21194981 doi: 10.1016/j.immuni.2010.12.009
Lindemans CA, Calafiore M, Mertelsmann AM, O’Connor MH, Dudakov JA, Jenq RR, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015;528:560–4.
pubmed: 26649819 pmcid: 4720437 doi: 10.1038/nature16460
Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010;464:1371–5.
pubmed: 20393462 pmcid: 3796764 doi: 10.1038/nature08949
Hepworth MR, Monticelli LA, Fung TC, Ziegler CGK, Grunberg S, Sinha R, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013;498:113–7.
pubmed: 23698371 pmcid: 3699860 doi: 10.1038/nature12240
Bar‐Ephraïm YE, Mebius RE. Innate lymphoid cells in secondary lymphoid organs. Immunol Rev. 2016;271:185–99.
pubmed: 27088915 doi: 10.1111/imr.12407
Graça CG, da, Baarsen LGM, van, Mebius RE. Tertiary lymphoid structures: diversity in their development, composition, and role. J Immunol. 2021;206:273–81.
doi: 10.4049/jimmunol.2000873
Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld J-C, Frankel G, et al. The Chemokine receptor CXCR6 controls the functional topography of Interleukin-22 producing intestinal innate lymphoid cells. Immunity. 2014;41:776–88.
pubmed: 25456160 doi: 10.1016/j.immuni.2014.10.007
Kim MH, Taparowsky EJ, Kim CH. Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut. Immunity. 2015;43:107–19.
pubmed: 26141583 pmcid: 4511719 doi: 10.1016/j.immuni.2015.06.009
Kobayashi T, Voisin B, Kim DY, Kennedy EA, Jo J-H, Shih H-Y, et al. Homeostatic control of sebaceous glands by innate lymphoid cells regulates commensal bacteria equilibrium. Cell. 2019;176:982–.e16.
pubmed: 30712873 pmcid: 6532063 doi: 10.1016/j.cell.2018.12.031
Hoorweg K, Peters CP, Cornelissen F, Aparicio-Domingo P, Papazian N, Kazemier G, et al. Functional differences between human NKp44− and NKp44+ RORC+ innate lymphoid cells. Front Immunol. 2012;3:72.
pubmed: 22566953 pmcid: 3342004 doi: 10.3389/fimmu.2012.00072
Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet. 2018;391:1285–1300.
pubmed: 29248255 doi: 10.1016/S0140-6736(17)33293-2
Laghlali G, Lawlor KE, Tate MD. Die another way: interplay between Influenza A virus, inflammation and cell death. Viruses. 2020;12:401.
pubmed: 32260457 pmcid: 7232208 doi: 10.3390/v12040401
Gazit R, Gruda R, Elboim M, Arnon TI, Katz G, Achdout H, et al. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 2006;7:517–23.
pubmed: 16565719 doi: 10.1038/ni1322
Mandelboim O, Lieberman N, Lev M, Paul L, Arnon TI, Bushkin Y, et al. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature. 2001;409:1055–60.
pubmed: 11234016 doi: 10.1038/35059110
Jegaskanda S, Weinfurter JT, Friedrich TC, Kent SJ. Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 Influenza virus infection of Macaques. J Virol. 2013;87:5512–22.
pubmed: 23468501 pmcid: 3648138 doi: 10.1128/JVI.03030-12
Carlin LE, Hemann EA, Zacharias ZR, Heusel JW, Legge KL. Natural killer cell recruitment to the lung during Influenza A virus infection is dependent on CXCR3, CCR5, and virus exposure dose. Front Immunol. 2018;9:781.
pubmed: 29719539 pmcid: 5913326 doi: 10.3389/fimmu.2018.00781
Scharenberg M, Vangeti S, Kekäläinen E, Bergman P, Al-Ameri M, Johansson N, et al. Influenza A virus infection induces hyperresponsiveness in human lung tissue-resident and peripheral blood NK cells. Front Immunol. 2019;10:1116.
pubmed: 31156653 pmcid: 6534051 doi: 10.3389/fimmu.2019.01116
Wu X, Kasmani MY, Zheng S, Khatun A, Chen Y, Winkler W, et al. BATF promotes group 2 innate lymphoid cell–mediated lung tissue protection during acute respiratory virus infection. Sci Immunol. 2022;7:eabc9934.
pubmed: 35030033 pmcid: 9005262 doi: 10.1126/sciimmunol.abc9934
Vashist N, Trittel S, Ebensen T, Chambers BJ, Guzmán CA, Riese P. Influenza-activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression. Front Immunol. 2018;9:505.
pubmed: 29623077 pmcid: 5874297 doi: 10.3389/fimmu.2018.00505
Califano D, Furuya Y, Roberts S, Avram D, McKenzie ANJ, Metzger DW. IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells. Mucosal Immunol. 2018;11:209–19.
pubmed: 28513592 doi: 10.1038/mi.2017.41
Williams CM, Roy S, Califano D, McKenzie ANJ, Metzger DW, Furuya Y. The Interleukin-33–Group 2 innate lymphoid cell axis represents a potential adjuvant target to increase the cross-protective efficacy of influenza vaccine. J Virol. 2021;95:e00598–21.
pubmed: 34468174 pmcid: 8549502 doi: 10.1128/JVI.00598-21
Barman TK, Huber VC, Bonin JL, Califano D, Salmon SL, McKenzie ANJ, et al. Viral PB1-F2 and host IFN-γ guide ILC2 and T cell activity during influenza virus infection. Proc Natl Acad Sci USA. 2022;119:e2118535119.
pubmed: 35169077 pmcid: 8872759 doi: 10.1073/pnas.2118535119
Gorski SA, Hahn YS, Braciale TJ. Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection. PLoS Pathog. 2013;9:e1003615.
pubmed: 24068930 pmcid: 3777868 doi: 10.1371/journal.ppat.1003615
Jackson DJ, Makrinioti H, Rana BMJ, Shamji BWH, Trujillo-Torralbo M-B, Footitt J, et al. IL-33–dependent Type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med. 2014;190:1373–82.
pubmed: 25350863 pmcid: 4299647 doi: 10.1164/rccm.201406-1039OC
Dhariwal, Cameron J, Wong A, Paulsen E, Trujillo-Torralbo M, Rosario M-B, et al. Pulmonary innate lymphoid cell responses during rhinovirus-induced asthma exacerbations in vivo: a clinical trial. Am J Respir Crit Care Med. 2021;204:1259–73.
pubmed: 34469272 pmcid: 8786078 doi: 10.1164/rccm.202010-3754OC
Vu LD, Siefker D, Jones TL, You D, Taylor R, DeVincenzo J, et al. Elevated levels of Type 2 respiratory innate lymphoid cells in human infants with severe respiratory syncytial virus Bronchiolitis. Am J Respir Crit Care Med. 2019;200:1414–23.
pubmed: 31237777 pmcid: 6884055 doi: 10.1164/rccm.201812-2366OC
Hong JY, Bentley JK, Chung Y, Lei J, Steenrod JM, Chen Q, et al. Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells. J Allergy Clin Immunol. 2014;134:429–.e8.
pubmed: 24910174 pmcid: 4119851 doi: 10.1016/j.jaci.2014.04.020
Saravia J, You D, Shrestha B, Jaligama S, Siefker D, Lee GI, et al. Respiratory syncytial virus disease is mediated by age-variable IL-33. PLoS Pathog. 2015;11:e1005217.
pubmed: 26473724 pmcid: 4608776 doi: 10.1371/journal.ppat.1005217
Shim DH, Park YA, Kim MJ, Hong JY, Baek JY, Kim KW, et al. Pandemic influenza virus, pH1N1, induces asthmatic symptoms via activation of innate lymphoid cells. Pediatr Allergy Immunol. 2015;26:780–8.
pubmed: 26287507 doi: 10.1111/pai.12462
Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, et al. Respiratory syncytial virus infection activates IL–13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J Allergy Clin Immunol. 2016;138:814–.e11.
pubmed: 27156176 pmcid: 5014571 doi: 10.1016/j.jaci.2016.01.050
Han M, Hong JY, Jaipalli S, Rajput C, Lei J, Hinde JL, et al. IFN-γ blocks development of an asthma phenotype in rhinovirus-infected baby mice by inhibiting Type 2 innate lymphoid cells. Am J Respir Cell Mol Biol. 2016;56:242–51.
doi: 10.1165/rcmb.2016-0056OC
Han M, Ishikawa T, Bermick JR, Rajput C, Lei J, Goldsmith AM, et al. IL‐1β prevents ILC2 expansion, type 2 cytokine secretion, and mucus metaplasia in response to early‐life rhinovirus infection in mice. Allergy. 2020;75:2005–19.
pubmed: 32086822 doi: 10.1111/all.14241
Wu Y, Lai AC, Chi P, Thio CL, Chen W, Tsai C, et al. Pulmonary IL‐33 orchestrates innate immune cells to mediate respiratory syncytial virus‐evoked airway hyperreactivity and eosinophilia. Allergy. 2020;75:818–30.
pubmed: 31622507 doi: 10.1111/all.14091
Malinczak C-A, Fonseca W, Rasky AJ, Ptaschinski C, Morris S, Ziegler SF, et al. Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. Mucosal Immunol. 2019;12:969–79.
pubmed: 31076663 pmcid: 6599479 doi: 10.1038/s41385-019-0171-3
Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, et al. STAT1 represses Cytokine-producing Group 2 and Group 3 innate lymphoid cells during viral infection. J Immunol. 2017;199:510–9.
pubmed: 28576981 doi: 10.4049/jimmunol.1601984
Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, et al. Clinical characteristics of Coronavirus disease 2019 in China. N. Engl J Med. 2020;382:1708–20.
pubmed: 32109013 doi: 10.1056/NEJMoa2002032
Hammer Q, Cuapio A, Bister J, Björkström NK, Ljunggren H-G. NK cells in COVID-19—from disease to vaccination. J Leukoc Biol. 2023;114:507–12.
pubmed: 36976012 doi: 10.1093/jleuko/qiad031
Maucourant C, Filipovic I, Ponzetta A, Aleman S, Cornillet M, Hertwig L, et al. Natural killer cell immunotypes related to COVID-19 disease severity. Sci Immunol. 2020;5:eabd6832.
pubmed: 32826343 pmcid: 7665314 doi: 10.1126/sciimmunol.abd6832
Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, et al. Universal principled review: a community-driven method to improve peer review. Cell. 2019;179:1441–5.
pubmed: 31835023 doi: 10.1016/j.cell.2019.11.029
Varchetta S, Mele D, Oliviero B, Mantovani S, Ludovisi S, Cerino A, et al. Unique immunological profile in patients with COVID-19. Cell Mol Immunol. 2021;18:604–12.
pubmed: 33060840 doi: 10.1038/s41423-020-00557-9
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021;600:295–301.
pubmed: 34695836 doi: 10.1038/s41586-021-04142-6
Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martínez-Colón GJ, McKechnie JL, et al. A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat Med. 2020;26:1070–6.
pubmed: 32514174 pmcid: 7382903 doi: 10.1038/s41591-020-0944-y
Xu G, Qi F, Li H, Yang Q, Wang H, Wang X, et al. The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. Cell Discov. 2020;6:73.
pubmed: 33101705 pmcid: 7574992 doi: 10.1038/s41421-020-00225-2
Liao M, Liu Y, Yuan J, Wen Y, Xu G, Zhao J, et al. Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19. Nat Med. 2020;26:842–4.
pubmed: 32398875 doi: 10.1038/s41591-020-0901-9
García M, Kokkinou E, García AC, Parrot T, Medina LMP, Maleki KT, et al. Innate lymphoid cell composition associates with COVID‐19 disease severity. Clin Transl Immunol. 2020;9:e1224.
doi: 10.1002/cti2.1224
Gomez-Cadena A, Spehner L, Kroemer M, Khelil MB, Bouiller K, Verdeil G, et al. Severe COVID-19 patients exhibit an ILC2 NKG2D+ population in their impaired ILC compartment. Cell Mol Immunol. 2021;18:484–6.
pubmed: 33318627 doi: 10.1038/s41423-020-00596-2
Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, et al. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19. Immunity. 2021;54:2650–.e14.
pubmed: 34592166 pmcid: 8416549 doi: 10.1016/j.immuni.2021.09.002
Huot N, Planchais C, Rosenbaum P, Contreras V, Jacquelin B, Petitdemange C, et al. SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells. Nat Immunol 2023;24:2068–79.
Hammer Q, Dunst J, Christ W, Picarazzi F, Wendorff M, Momayyezi P, et al. SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells. Cell Rep. 2022;38:110503.
pubmed: 35235832 pmcid: 8858686 doi: 10.1016/j.celrep.2022.110503
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504–7.
pubmed: 23563266 pmcid: 3651993 doi: 10.1038/nature12060
Azeredo EL, Oliveira‐Pinto LMD, Zagne SM, Cerqueira DIS, Nogueira RMR, Kubelka CF. NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. Clin Exp Immunol. 2006;143:345–56.
pubmed: 16412060 pmcid: 1809585 doi: 10.1111/j.1365-2249.2006.02996.x
Zimmer CL, Cornillet M, Solà-Riera C, Cheung K-W, Ivarsson MA, Lim MQ, et al. NK cells are activated and primed for skin-homing during acute dengue virus infection in humans. Nat Commun. 2019;10:3897.
pubmed: 31467285 pmcid: 6715742 doi: 10.1038/s41467-019-11878-3
Hershkovitz O, Rosental B, Rosenberg LA, Navarro-Sanchez ME, Jivov S, Zilka A, et al. NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and Dengue viruses with NK cells. J Immunol. 2009;183:2610–21.
pubmed: 19635919 doi: 10.4049/jimmunol.0802806
Piersma SJ, Poursine-Laurent J, Yang L, Barber GN, Parikh BA, Yokoyama WM. Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. elife. 2020;9:e56882.
pubmed: 32723479 pmcid: 7413665 doi: 10.7554/eLife.56882
Piersma SJ, Bangru S, Yoon J, Liu TW, Yang L, Hsieh C-S, et al. NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection. J Exp Med. 2023;220:e20231154.
pubmed: 37698554 pmcid: 10497399 doi: 10.1084/jem.20231154
Weizman O-E, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, et al. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat Immunol. 2019;20:1004–11.
pubmed: 31263280 pmcid: 6697419 doi: 10.1038/s41590-019-0430-1
Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popović B, Tanaka M, et al. A viral Immunoevasin controls innate immunity by targeting the prototypical natural killer cell receptor family. Cell. 2017;169:58–71.e14.
pubmed: 28340350 doi: 10.1016/j.cell.2017.03.002
Paust S, Gill HS, Wang B-Z, Flynn MP, Moseman EA, Senman B, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010;11:1127–35.
pubmed: 20972432 pmcid: 2982944 doi: 10.1038/ni.1953
Buchanan R, Hydes T, Khakoo SI. Innate and adaptive genetic pathways in HCV infection. Tissue Antigens. 2015;85:231–40.
pubmed: 25708172 doi: 10.1111/tan.12540
Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, et al. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 2004;305:872–4.
pubmed: 15297676 doi: 10.1126/science.1097670
Amadei B, Urbani S, Cazaly A, Fisicaro P, Zerbini A, Ahmed P, et al. Activation of natural killer cells during acute infection with Hepatitis C virus. Gastroenterology. 2010;138:1536–45.
pubmed: 20080094 doi: 10.1053/j.gastro.2010.01.006
Alter G, Jost S, Rihn S, Reyor LL, Nolan BE, Ghebremichael M, et al. Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. J Hepatol. 2011;55:278–88.
pubmed: 21168454 doi: 10.1016/j.jhep.2010.11.030
Thoens C, Berger C, Trippler M, Siemann H, Lutterbeck M, Broering R, et al. KIR2DL3+NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs. J Hepatol. 2014;61:475–81.
pubmed: 24780303 doi: 10.1016/j.jhep.2014.04.020
Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage. J Exp Med. 2007;204:667–80.
pubmed: 17353365 pmcid: 2137916 doi: 10.1084/jem.20061287
Sprengers, Molen D, van der RG, Kusters JG, Hansen B, Niesters HGM, et al. Different composition of intrahepatic lymphocytes in the immune‐tolerance and immune‐clearance phase of chronic hepatitis B. J Méd Virol. 2006;78:561–8.
pubmed: 16555293 doi: 10.1002/jmv.20576
Peppa D, Micco L, Javaid A, Kennedy PTF, Schurich A, Dunn C, et al. Blockade of Immunosuppressive Cytokines restores NK cell antiviral function in chronic Hepatitis B Virus Infection. PLoS Pathog. 2010;6:e1001227.
pubmed: 21187913 pmcid: 3003000 doi: 10.1371/journal.ppat.1001227
Oliviero B, Varchetta S, Paudice E, Michelone G, Zaramella M, Mavilio D, et al. Natural killer cell functional dichotomy in chronic Hepatitis B and chronic Hepatitis C Virus infections. Gastroenterology. 2009;137:1151–.e7.
pubmed: 19470388 doi: 10.1053/j.gastro.2009.05.047
Peppa D, Gill US, Reynolds G, Easom NJW, Pallett LJ, Schurich A, et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion. J Exp Med. 2013;210:99–114.
pubmed: 23254287 pmcid: 3549717 doi: 10.1084/jem.20121172
Zhou J, Peng H, Li K, Qu K, Wang B, Wu Y, et al. Liver-resident NK cells control antiviral activity of hepatic T cells via the PD-1-PD-L1 axis. Immunity. 2019;50:403–.e4.
pubmed: 30709740 doi: 10.1016/j.immuni.2018.12.024
Liang Y, Yi P, Yuan DMK, Jie Z, Kwota Z, Soong L, et al. IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol. 2019;16:126–37.
pubmed: 29400707 doi: 10.1038/cmi.2017.147
Lasrado N, Reddy J. An overview of the immune mechanisms of viral myocarditis. Rev Méd Virol. 2020;30:1–14.
pubmed: 32720461 doi: 10.1002/rmv.2131
Tian Y, Gong X, Qin D, Cao Y, Zhang S, Xia L, et al. S1PR1-dependent migration of ILC3s from intestinal tissue to the heart in a mouse model of viral myocarditis. J Leukoc Biol. 2023;114:154–63.
pubmed: 37141387 doi: 10.1093/jleuko/qiad048
Yuan J, Liu Z, Lim T, Zhang H, He J, Walker E, et al. CXCL10 inhibits viral replication through recruitment of natural killer cells in Coxsackievirus B3-induced Myocarditis. Circ Res. 2009;104:628–38.
pubmed: 19168435 doi: 10.1161/CIRCRESAHA.108.192179
Klingel K, Fabritius C, Sauter M, Göldner K, Stauch D, Kandolf R, et al. The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus‐mediated inflammatory cardiomyopathy. J Pathol. 2014;234:164–77.
pubmed: 24797160 doi: 10.1002/path.4369
Müller I, Janson L, Sauter M, Pappritz K, Linthout SV, Tschöpe C, et al. Myeloid-derived suppressor cells restrain natural killer cell activity in acute Coxsackievirus B3-Induced Myocarditis. Viruses. 2021;13:889.
pubmed: 34065891 pmcid: 8151145 doi: 10.3390/v13050889
Shannon JP, Vrba SM, Reynoso GV, Wynne-Jones E, Kamenyeva O, Malo CS, et al. Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium. Immunity. 2021;54:276–.e5.
pubmed: 33434494 pmcid: 7881522 doi: 10.1016/j.immuni.2020.12.004
Fenner F. Global eradication of smallpox. Clin Infect Dis. 1982;4:916–30.
doi: 10.1093/clinids/4.5.916
Ramig RF. Pathogenesis of intestinal and systemic Rotavirus infection. J Virol. 2004;78:10213–20.
pubmed: 15367586 pmcid: 516399 doi: 10.1128/JVI.78.19.10213-10220.2004
Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, et al. Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18. Science. 2014;346:861–5.
pubmed: 25395539 pmcid: 4788408 doi: 10.1126/science.1256999
Hernández PP, Mahlakõiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, et al. Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nat Immunol. 2015;16:698–707.
pubmed: 26006013 pmcid: 4589158 doi: 10.1038/ni.3180
Shah SV, Manickam C, Ram DR, Reeves RK. Innate lymphoid cells in HIV/SIV infections. Front Immunol. 2017;8:1818.
pubmed: 29326704 pmcid: 5733347 doi: 10.3389/fimmu.2017.01818
Assimakopoulos SF, Dimitropoulou D, Marangos M, Gogos CA. Intestinal barrier dysfunction in HIV infection: pathophysiology, clinical implications and potential therapies. Infection. 2014;42:951–9.
pubmed: 25070877 doi: 10.1007/s15010-014-0666-5
Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, et al. Plasmacytoid dendritic cells promote HIV-1–induced group 3 innate lymphoid cell depletion. J Clin Investig. 2015;125:3692–703.
pubmed: 26301812 pmcid: 4588300 doi: 10.1172/JCI82124
Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646–57.
pubmed: 22643849 pmcid: 3443541 doi: 10.1038/mi.2012.38
Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, et al. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Pathog. 2014;10:e1004551.
pubmed: 25503264 pmcid: 4263758 doi: 10.1371/journal.ppat.1004551
Xu H, Wang X, Lackner AA, Veazey RS. Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus‐infected macaques. FASEB J. 2015;29:5072–80.
pubmed: 26283536 pmcid: 4653054 doi: 10.1096/fj.15-276477
Krämer B, Goeser F, Lutz P, Glässner A, Boesecke C, Schwarze-Zander C, et al. Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy. PLoS Pathog. 2017;13:e1006373.
pubmed: 28505204 pmcid: 5444854 doi: 10.1371/journal.ppat.1006373
Zhao J, Cheng L, Wang H, Yu H, Tu B, Fu Q, et al. Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway. PLoS Pathog. 2018;14:e1006819.
pubmed: 29304123 pmcid: 5773236 doi: 10.1371/journal.ppat.1006819
Hueber B, Curtis AD, Kroll K, Varner V, Jones R, Pathak S, et al. Functional perturbation of mucosal Group 3 innate lymphoid and natural killer cells in Simian-Human Immunodeficiency Virus/Simian immunodeficiency virus-infected infant Rhesus Macaques. J Virol. 2019;94:e01644–19.
Looker KJ, Elmes JAR, Gottlieb SL, Schiffer JT, Vickerman P, Turner KME, et al. Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis. Lancet Infect Dis. 2017;17:1303–16.
pubmed: 28843576 pmcid: 5700807 doi: 10.1016/S1473-3099(17)30405-X
Thapa M, Kuziel WA, Carr DJJ. Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol. 2007;81:3704–13.
pubmed: 17267483 pmcid: 1866094 doi: 10.1128/JVI.02626-06
Lebratti T, Lim YS, Cofie A, Andhey P, Jiang X, Scott J, et al. A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection. eLife. 2021;10:e65762.
pubmed: 34047696 pmcid: 8163503 doi: 10.7554/eLife.65762
Lim YS, Lee AG, Jiang X, Scott JM, Cofie A, Kumar S, et al. NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection. Cell Rep. 2023;42:112410.
pubmed: 37071533 doi: 10.1016/j.celrep.2023.112410
Lee AG, Scott JM, Fabbrizi MR, Jiang X, Sojka DK, Miller MJ, et al. T cell response kinetics determines neuroinfection outcomes during murine HSV infection. JCI Insight. 2020;5:e134258.
pubmed: 32161194 pmcid: 7141405 doi: 10.1172/jci.insight.134258
Croese T, Castellani G, Schwartz M. Immune cell compartmentalization for brain surveillance and protection. Nat Immunol. 2021;22:1083–92.
pubmed: 34429552 doi: 10.1038/s41590-021-00994-2
Kveštak D, Mihalić A, Jonjić S, Brizić I. Innate lymphoid cells in neuroinflammation. Front Cell Neurosci. 2024;18:1364485.
pubmed: 38450285 pmcid: 10915051 doi: 10.3389/fncel.2024.1364485
Boppana SB, Ross SA, Fowler KB. Congenital Cytomegalovirus infection: clinical outcome. Clin Infect Dis. 2013;57:S178–S181.
pubmed: 24257422 pmcid: 4471438 doi: 10.1093/cid/cit629
Koontz T, Bralic M, Tomac J, Pernjak-Pugel E, Bantug G, Jonjic S, et al. Altered development of the brain after focal herpesvirus infection of the central nervous system. J Exp Med. 2008;205:423–35.
pubmed: 18268036 pmcid: 2271002 doi: 10.1084/jem.20071489
Kveštak D, Lisnić VJ, Lisnić B, Tomac J, Golemac M, Brizić I, et al. NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. J Exp Med. 2021;218:e20201503.
pubmed: 33630019 pmcid: 7918636 doi: 10.1084/jem.20201503
Rožmanić C, Lisnić B, Matešić MP, Mihalić A, Hiršl L, Park E, et al. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nat Commun. 2023;14:6412.
pubmed: 37828009 pmcid: 10570381 doi: 10.1038/s41467-023-42182-w
Sellier Y, Marliot F, Bessières B, Stirnemann J, Encha-Razavi F, Guilleminot T, et al. Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains. Microorganisms. 2020;8:176.
pubmed: 31991822 pmcid: 7074756 doi: 10.3390/microorganisms8020176
Alsharifi M, Lobigs M, Simon MM, Kersten A, Müller K, Koskinen A, et al. NK cell‐mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol. 2006;36:887–96.
pubmed: 16541469 doi: 10.1002/eji.200535342
Trifilo MJ, Montalto-Morrison C, Stiles LN, Hurst KR, Hardison JL, Manning JE, et al. CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol. 2003;78:585–94.
doi: 10.1128/JVI.78.2.585-594.2004
Lee H-N, Manangeeswaran M, Lewkowicz AP, Engel K, Chowdhury M, Garige M, et al. NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice. JCI Insight. 2022;7:e151420.
pubmed: 35132958 pmcid: 8855830 doi: 10.1172/jci.insight.151420
Hirose S, Jahani PS, Wang S, Jaggi U, Tormanen K, Yu J, et al. Type 2 innate lymphoid cells induce CNS Demyelination in an HSV-IL-2 mouse model of multiple Sclerosis. iScience. 2020;23:101549.
pubmed: 33083718 pmcid: 7522755 doi: 10.1016/j.isci.2020.101549
Kulcsar KA, Baxter VK, Greene IP, Griffin DE. Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Proc Natl Acad Sci. 2014;111:16053–8.
pubmed: 25362048 pmcid: 4234572 doi: 10.1073/pnas.1418966111
Martin NM, Griffin DE. Effect of IL-10 deficiency on TGFβ expression during fatal Alphavirus Encephalomyelitis in C57Bl/6 mice. Viruses. 2022;14:1791.
pubmed: 36016413 pmcid: 9416572 doi: 10.3390/v14081791
Adams NM, Sun JC. Spatial and temporal coordination of antiviral responses by group 1 ILCs. Immunol Rev. 2018;286:23–36.
pubmed: 30294970 pmcid: 6178831 doi: 10.1111/imr.12710
Orange JS, Biron CA. An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. J Immunol. 1996;156:1138–42.
pubmed: 8557990 doi: 10.4049/jimmunol.156.3.1138
Dorner BG, Smith HRC, French AR, Kim S, Poursine-Laurent J, Beckman DL, et al. Coordinate expression of cytokines and chemokines by NK cells during murine cytomegalovirus infection. J Immunol. 2004;172:3119–31.
pubmed: 14978118 doi: 10.4049/jimmunol.172.5.3119
Verma S, Wang Q, Chodaczek G, Benedict CA. Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus. J Virol. 2013;87:6201–10.
pubmed: 23536654 pmcid: 3648091 doi: 10.1128/JVI.00113-13
Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, et al. A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013;210:2939–50.
pubmed: 24323357 pmcid: 3865470 doi: 10.1084/jem.20130351
Zaiss DMW, Gause WC, Osborne LC, Artis D. Emerging functions of Amphiregulin in Orchestrating Immunity, Inflammation, And Tissue Repair. Immunity. 2015;42:216–26.
pubmed: 25692699 pmcid: 4792035 doi: 10.1016/j.immuni.2015.01.020
Allen JE. IL-4 and IL-13: Regulators and effectors of wound repair. Annu Rev Immunol. 2023;41:229–54.
pubmed: 36737597 doi: 10.1146/annurev-immunol-101921-041206
Ising R, Weinhold S, Bennstein SB, Zimmermann A, Degistirici Ö, Kögler G, et al. HCMV infection in a Mesenchymal stem cell niche: differential impact on the development of NK cells versus ILC3. J Clin Med. 2019;9:10.
pubmed: 31861547 pmcid: 7027004 doi: 10.3390/jcm9010010

Auteurs

Sytse J Piersma (SJ)

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. spiersma@wustl.edu.
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. spiersma@wustl.edu.

Classifications MeSH