Abstract deliberation by visuomotor neurons in prefrontal cortex.

Journal

Nature neuroscience

ISSN: 1546-1726

Titre abrégé: Nat Neurosci

Pays: United States

ID NLM: 9809671

Informations de publication

Date de publication:
29 Apr 2024

Historique:

received: 31 01 2023

accepted: 29 03 2024

medline: 30 4 2024

pubmed: 30 4 2024

entrez: 29 4 2024

Statut: aheadofprint

Résumé

During visually guided behavior, the prefrontal cortex plays a pivotal role in mapping sensory inputs onto appropriate motor plans. When the sensory input is ambiguous, this involves deliberation. It is not known whether the deliberation is implemented as a competition between possible stimulus interpretations or between possible motor plans. Here we study neural population activity in the prefrontal cortex of macaque monkeys trained to flexibly report perceptual judgments of ambiguous visual stimuli. We find that the population activity initially represents the formation of a perceptual choice before transitioning into the representation of the motor plan. Stimulus strength and prior expectations both bear on the formation of the perceptual choice, but not on the formation of the action plan. These results suggest that prefrontal circuits involved in action selection are also used for the deliberation of abstract propositions divorced from a specific motor plan, thus providing a crucial mechanism for abstract reasoning.

Identifiants

DOI: 10.1038/s41593-024-01635-1 PMID: 38684894

pubmed: 38684894

doi: 10.1038/s41593-024-01635-1

pii: 10.1038/s41593-024-01635-1

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : NEI NIH HHS

ID : T32 EY021462

Pays : United States

Informations de copyright

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