Exploring patients' perspectives: a mixed methods study on Outpatient Parenteral Antimicrobial Therapy (OPAT) experiences.
Humans
Female
Male
Patient Satisfaction
Middle Aged
Germany
Ambulatory Care
Aged
Adult
Anti-Infective Agents
/ administration & dosage
Infusions, Parenteral
Surveys and Questionnaires
Anti-Bacterial Agents
/ administration & dosage
Interviews as Topic
Qualitative Research
Aged, 80 and over
Pilot Projects
Bacterial/viral infections
Intravenous therapy
OPAT
Outpatient Parenteral Antimicrobial Therapy
Patient Reported Outcome Measures
Patient satisfaction
Journal
BMC health services research
ISSN: 1472-6963
Titre abrégé: BMC Health Serv Res
Pays: England
ID NLM: 101088677
Informations de publication
Date de publication:
29 Apr 2024
29 Apr 2024
Historique:
received:
20
02
2024
accepted:
19
04
2024
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
29
4
2024
Statut:
epublish
Résumé
Outpatient Parenteral Antimicrobial Therapy (OPAT), an alternative to inpatient intravenous antibiotic therapy, has shown benefits in international studies such as increased patient satisfaction. Because OPAT has been used only sporadically in Germany so far, no structured results on patients' experiences and concerns regarding OPAT have yet been available. This study therefore aims to explore the experiences of OPAT patients in a pilot region in Germany. This is an observational study in a German pilot region, including a survey of 58 patients on their experiences with OPAT, and in-depth interviews with 12 patients (explanatory-sequential mixed-methods design). Patients reported that they were satisfied with OPAT. That a hospital discharge was possible and anti-infective therapy could be continued in the home environment was rated as being particularly positive. In the beginning, many patients in the interviews were unsure about being able to administer the antibiotic therapy at home on their own. However, healthcare providers (doctors and pharmacy service provider staff) were able to allay these concerns. Patients appreciated regular contact with care providers. There were suggestions for improvement, particularly concerning the organization of the weekly check-up appointments and the provision of information about OPAT. Patients were generally satisfied with OPAT. However, the treatment structures in Germany still need to be expanded to ensure comprehensive and high-quality OPAT care. NCT04002453, https://www. gov/ , (registration date: 2019-06-21).
Sections du résumé
BACKGROUND
BACKGROUND
Outpatient Parenteral Antimicrobial Therapy (OPAT), an alternative to inpatient intravenous antibiotic therapy, has shown benefits in international studies such as increased patient satisfaction. Because OPAT has been used only sporadically in Germany so far, no structured results on patients' experiences and concerns regarding OPAT have yet been available. This study therefore aims to explore the experiences of OPAT patients in a pilot region in Germany.
METHODS
METHODS
This is an observational study in a German pilot region, including a survey of 58 patients on their experiences with OPAT, and in-depth interviews with 12 patients (explanatory-sequential mixed-methods design).
RESULTS
RESULTS
Patients reported that they were satisfied with OPAT. That a hospital discharge was possible and anti-infective therapy could be continued in the home environment was rated as being particularly positive. In the beginning, many patients in the interviews were unsure about being able to administer the antibiotic therapy at home on their own. However, healthcare providers (doctors and pharmacy service provider staff) were able to allay these concerns. Patients appreciated regular contact with care providers. There were suggestions for improvement, particularly concerning the organization of the weekly check-up appointments and the provision of information about OPAT.
CONCLUSIONS
CONCLUSIONS
Patients were generally satisfied with OPAT. However, the treatment structures in Germany still need to be expanded to ensure comprehensive and high-quality OPAT care.
TRIAL REGISTRATION
BACKGROUND
NCT04002453, https://www.
CLINICALTRIALS
RESULTS
gov/ , (registration date: 2019-06-21).
Identifiants
pubmed: 38685017
doi: 10.1186/s12913-024-11017-9
pii: 10.1186/s12913-024-11017-9
doi:
Substances chimiques
Anti-Infective Agents
0
Anti-Bacterial Agents
0
Banques de données
ClinicalTrials.gov
['NCT04002453']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
544Informations de copyright
© 2024. The Author(s).
Références
Terhalle E, Jung N, Stegemann MS, Priesner V, Lehmann C, Schmiedel S. Neue Entwicklungen in der ambulanten parenteralen Antibiotikatherapie (APAT). [New developments in outpatient parenteral antibiotic therapy (OPAT)]. Dtsch Med Wochenschr. 2020;145:1688–94. https://doi.org/10.1055/a-1114-3990 .
doi: 10.1055/a-1114-3990
pubmed: 33202453
Stegemann M, Hagel S, Lehmann C. Antibiotikatherapie (2): Ambulante parenterale Gabe. Deutsches Ärzteblatt Online. 2019. https://doi.org/10.3238/PersInfek.2019.07.22.03 .
doi: 10.3238/PersInfek.2019.07.22.03
Norris AH, Shrestha NK, Allison GM, Keller SC, Bhavan KP, Zurlo JJ, et al. 2018 infectious diseases society of America clinical practice guideline for the management of outpatient parenteral antimicrobial therapy. Clin Infect Dis. 2019;68:e1–35. https://doi.org/10.1093/cid/ciy745 .
doi: 10.1093/cid/ciy745
pubmed: 30423035
Petrak RM, Skorodin NC, Fliegelman RM, Hines DW, Chundi VV, Harting BP. Value and clinical impact of an infectious disease-supervised outpatient parenteral antibiotic therapy program. Open Forum Infect Dis. 2016;3:ofw193. https://doi.org/10.1093/ofid/ofw193 .
doi: 10.1093/ofid/ofw193
pubmed: 27807591
pmcid: 5088696
Rentala M, Andrews S, Tiberio A, Alagappan K, Tavdy T, Sheppard P, Silverman R. Intravenous home infusion therapy instituted from a 24-hour clinical decision unit for patients with cellulitis. Am J Emerg Med. 2016;34:1273–5. https://doi.org/10.1016/j.ajem.2016.04.022 .
doi: 10.1016/j.ajem.2016.04.022
pubmed: 27182030
Kayley J, Berendt AR, Snelling MJ, Moore H, Hamilton HC, Peto TE, et al. Safe intravenous antibiotic therapy at home: experience of a UK based programme. J Antimicrob Chemother. 1996;37:1023–9. https://doi.org/10.1093/jac/37.5.1023 .
doi: 10.1093/jac/37.5.1023
pubmed: 8737154
Dalovisio JR, Juneau J, Baumgarten K, Kateiva J. Financial impact of a home intravenous antibiotic program on a medicare managed care program. Clin Infect Dis. 2000;30:639–42. https://doi.org/10.1086/313755 .
doi: 10.1086/313755
pubmed: 10770722
Wolter JM, Cagney RA, McCormack JG. A randomized trial of home vs hospital intravenous antibiotic therapy in adults with infectious diseases. J Infect. 2004;48:263–8. https://doi.org/10.1016/S0163-4453(03)00135-X .
doi: 10.1016/S0163-4453(03)00135-X
pubmed: 15001305
Dimitrova M, Gilchrist M, Seaton RA. Outpatient parenteral antimicrobial therapy (OPAT) versus inpatient care in the UK: a health economic assessment for six key diagnoses. BMJ Open. 2021;11:e049733. https://doi.org/10.1136/bmjopen-2021-049733
doi: 10.1136/bmjopen-2021-049733
pubmed: 34588251
pmcid: 8479950
Giuliano G, Raffaelli F, Faliero D, Tamburrini E, Tarantino D, Nurchis MC, Scoppettuolo G. Outpatient parenteral antimicrobial therapy (OPAT) from an emergency model applied during the COVID-19 pandemic to standard of care: preliminary lessons from our experience. Infect Dis Now. 2023;53;104642. https://doi.org/10.1016/j.idnow.2023.01.002
doi: 10.1016/j.idnow.2023.01.002
pubmed: 36642101
pmcid: 9836987
Berrevoets MAH, Oerlemans AJM, Tromp M, Kullberg BJ, ten Oever J, Schouten JA, Hulscher ME. Quality of outpatient parenteral antimicrobial therapy (OPAT) care from the patient’s perspective: a qualitative study. BMJ Open. 2018;8: e024564. https://doi.org/10.1136/bmjopen-2018-024564 .
doi: 10.1136/bmjopen-2018-024564
pubmed: 30420352
pmcid: 6252647
Wong KK, Fraser TG, Shrestha NK, Fatica C, Deshpande A. Low incidence of Clostridium difficile infection (CDI) in patients treated with outpatient parenteral antimicrobial therapy (OPAT). Infect Control Hosp Epidemiol. 2015;36:110–2. https://doi.org/10.1017/ice.2014.6 .
doi: 10.1017/ice.2014.6
pubmed: 25627769
MacKenzie M, Rae N, Nathwani D. Outcomes from global adult outpatient parenteral antimicrobial therapy programmes: a review of the last decade. Int J Antimicrob Agents. 2014;43:7–16. https://doi.org/10.1016/j.ijantimicag.2013.09.006 .
doi: 10.1016/j.ijantimicag.2013.09.006
pubmed: 24200469
Staples JA, Ho M, Ferris D, Hayek J, Liu G, Tran KC, Sutherland JM. Outpatient Versus Inpatient Intravenous Antimicrobial Therapy: A Population-Based Observational Cohort Study of Adverse Events and Costs. Clin Infect Dis. 2022;75:1921–9. https://doi.org/10.1093/cid/ciac298 .
doi: 10.1093/cid/ciac298
pubmed: 35439822
Board N, Brennan N, Caplan GA. A randomised controlled trial of the costs of hospital as compared with hospital in the home for acute medical patients. Aust N Z J Public Health. 2000;24:305–11. https://doi.org/10.1111/j.1467-842x.2000.tb01573.x .
doi: 10.1111/j.1467-842x.2000.tb01573.x
pubmed: 10937409
Corwin P, Toop L, McGeoch G, Than M, Wynn-Thomas S, Wells JE, et al. Randomised controlled trial of intravenous antibiotic treatment for cellulitis at home compared with hospital. BMJ. 2005;330:129. https://doi.org/10.1136/bmj.38309.447975.EB .
doi: 10.1136/bmj.38309.447975.EB
pubmed: 15604157
pmcid: 544431
Chapman ALN, Seaton RA, Cooper MA, Hedderwick S, Goodall V, Reed C, et al. Good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults in the UK: a consensus statement. J Antimicrob Chemother. 2012;67:1053–62. https://doi.org/10.1093/jac/dks003 .
doi: 10.1093/jac/dks003
pubmed: 22298347
Hatcher J, Costelloe C, Cele R, Viljanen A, Samarasinghe D, Satta G, et al. Factors associated with successful completion of outpatient parenteral antibiotic therapy (OPAT): A 10-year review from a large West London service. Int J Antimicrob Agents. 2019;54:207–14. https://doi.org/10.1016/j.ijantimicag.2019.04.008 .
doi: 10.1016/j.ijantimicag.2019.04.008
pubmed: 30986525
Rieg S, Küpper MF. Infectious diseases consultations can make the difference: a brief review and a plea for more infectious diseases specialists in Germany. Infection. 2016;44:159–66. https://doi.org/10.1007/s15010-016-0883-1 .
doi: 10.1007/s15010-016-0883-1
pubmed: 26908131
Schmidt-Hellerau K, Baade N, Günther M, Scholten N, Lindemann CH, Leisse C, et al. Outpatient parenteral antimicrobial therapy (OPAT) in Germany: insights and clinical outcomes from the K-APAT cohort study. Infection. 2024. https://doi.org/10.1007/s15010-024-02199-9 .
doi: 10.1007/s15010-024-02199-9
pubmed: 38478255
Scholten N, Leisse C, Brandes V, Oberröhrmann C, Ihle P, Peter S, et al. Outpatient parenteral antimicrobial therapy in Germany: a prospective cohort study protocol. BMJ Open. 2022;12:e061417. https://doi.org/10.1136/bmjopen-2022-061417 .
doi: 10.1136/bmjopen-2022-061417
pubmed: 36375971
pmcid: 9664305
Cresswell JW. A concise introduction to mixed methods research. 2nd ed. Thousand Oaks, CA: SAGE Publications; 2022.
Ansari AA. Outpatient Parenteral Antimicrobial Therapy (OPAT) in the Kingdom of Bahrain: Efficacy. Patient Satisfaction and Cost Effectiveness TOIDJ. 2013;7:90–5. https://doi.org/10.2174/1874279301307010090 .
doi: 10.2174/1874279301307010090
Baecker H, Gessmann J, Hanusrichter Y, Zahn PK, Schildhauer TA, Frieler S. Die ambulante i. v. Antibiotikatherapie mittels PICC Line in der Behandlung von chronischen periprothetischen Infektionen. [Outpatient Parenteral Antibiotic Therapy (OPAT) with Peripherally Inserted Central Catheter in Patients with Periprosthetic Joint Infection]. Z Orthop Unfall. 2019;157:510–4. https://doi.org/10.1055/a-0830-4776 .
doi: 10.1055/a-0830-4776
pubmed: 31387123
Esposito S, Noviello S, Leone S, Tice A, Seibold G, Nathwani D, Scaglione F. Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison. Int J Antimicrob Agents. 2004;24:473–8. https://doi.org/10.1016/j.ijantimicag.2004.06.004 .
doi: 10.1016/j.ijantimicag.2004.06.004
pubmed: 15519480
Saillen L, Arensdorff L, Moulin E, Voumard R, Cochet C, Boillat-Blanco N, et al. Patient satisfaction in an outpatient parenteral antimicrobial therapy (OPAT) unit practising predominantly self-administration of antibiotics with elastomeric pumps. Eur J Clin Microbiol Infect Dis. 2017;36:1387–92. https://doi.org/10.1007/s10096-017-2944-5 .
doi: 10.1007/s10096-017-2944-5
pubmed: 28283831
Townsend J, Keller S, Tibuakuu M, Thakker S, Webster B, Siegel M, et al. Outpatient parenteral therapy for complicated Staphylococcus aureus infections: a snapshot of processes and outcomes in the real world. Open Forum Infect Dis. 2018;5:ofy274. https://doi.org/10.1093/ofid/ofy274 .
doi: 10.1093/ofid/ofy274
pubmed: 30488039
pmcid: 6251475
Twiddy M, Czoski Murray CJ, Mason SJ, Meads D, Wright JM, Mitchell ED, Minton J. A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England: implications for service improvement. BMJ Open. 2018;8:e019099. https://doi.org/10.1136/bmjopen-2017-019099
doi: 10.1136/bmjopen-2017-019099
pubmed: 29326190
pmcid: 5781150
Gardiol C, de Vallière S. Ambulante parenterale Antibiotikatherapie: Aktuelle Empfehlungen für die parenterale Behandlung von Infektionen. Swiss Medical Forum - Schweizerisches Medizin-Forum. 2016;16:314–8.
doi: 10.4414/smf.2016.02620
Lehmann C, Leisse C, Lindemann C, Scholten N, Oberröhrmann C, Ihle P, et al. Ergebnisbericht: Ambulante parenterale Antibiotikatherapie in der Kölner Metropolregion (K-APAT). 2023. https://innovationsfonds.g-ba.de/downloads/beschluss-dokumente/436/2023-08-16_K-APAT_Ergebnisbericht.pdf . Accessed 26 Mar 2024.
Kuckartz U. Qualitative Inhaltsanalyse: Methoden, Praxis, Computerunterstützung. 4th ed. Weinheim: Beltz Verlagsgruppe; 2018.
Quintens C, Steffens E, Jacobs K, Schuermans A, van Eldere J, Lagrou K, et al. Efficacy and safety of a Belgian tertiary care outpatient parenteral antimicrobial therapy (OPAT) program. Infection. 2020;48:357–66. https://doi.org/10.1007/s15010-020-01398-4 .
doi: 10.1007/s15010-020-01398-4
pubmed: 32060859
Gonçalves-Bradley DC, Lannin NA, Clemson L, Cameron ID, Shepperd S. Discharge planning from hospital. Cochrane Database Syst Rev. 2022;2:CD000313.
pubmed: 35199849
Mäkelä P, Stott D, Godfrey M, Ellis G, Schiff R, Shepperd S. The work of older people and their informal caregivers in managing an acute health event in a hospital at home or hospital inpatient setting. Age Ageing. 2020;49:856–64. https://doi.org/10.1093/ageing/afaa085 .
doi: 10.1093/ageing/afaa085
pubmed: 32428202
pmcid: 7444665
Chambers ST, Basevi A, Gallagher K, Carswell-Moyna A, Isenman H, Pithie A, et al. Outpatient parenteral antimicrobial therapy (OPAT) in Christchurch: 18 years on. N Z Med J. 2019;132:21–32.
pubmed: 31851658
Hase R, Yokoyama Y, Suzuki H, Uno S, Mikawa T, Suzuki D, et al. Review of the first comprehensive outpatient parenteral antimicrobial therapy program in a tertiary care hospital in Japan. Int J Infect Dis. 2020;95:210–5. https://doi.org/10.1016/j.ijid.2020.03.033 .
doi: 10.1016/j.ijid.2020.03.033
pubmed: 32205285
Kwok CS, Whittaker JJ, Malbon C, White B, Snape J, Lloyd V, et al. Outpatient parenteral antimicrobial therapy (OPAT) service is associated with inpatient-bed cost savings. Br J Cardiol. 2021;28:38. https://doi.org/10.5837/bjc.2021.038 .
doi: 10.5837/bjc.2021.038
pubmed: 35747699
pmcid: 8988795
Al Shareef HJ, Al Harbi A, Alatawi Y, Aljabri A, Al-Ghanmi MA, Alzahrani MS, et al. Evaluate the Effectiveness of Outpatient Parenteral Antimicrobial Therapy (OPAT) Program in Saudi Arabia: A Retrospective Study. Antibiotics (Basel). 2022. https://doi.org/10.3390/antibiotics11040441 .
doi: 10.3390/antibiotics11040441
pubmed: 35453192
Schoonenboom J, Johnson RB. How to Construct a Mixed Methods Research Design. Kolner Z Soz Sozpsychol. 2017;69:107–31. https://doi.org/10.1007/s11577-017-0454-1 .
doi: 10.1007/s11577-017-0454-1
pubmed: 28989188
pmcid: 5602001
Bundesministerium für Justiz. Sozialgesetzbuch (SGB) Fünftes Buch (V) - Gesetzliche Krankenversicherung - § 39 Krankenhausbehandlung; 1988. https://www.gesetze-im-internet.de/sgb_5/__39.html . Accessed 26 Mar 2024.
Chapman ALN, Patel S, Horner C, Gilchrist M, Seaton RA. Outpatient parenteral antimicrobial therapy: updated recommendations from the UK. J Antimicrob Chemother. 2019;74:3125–7. https://doi.org/10.1093/jac/dkz343 .
doi: 10.1093/jac/dkz343
pubmed: 31504575