Overview of systematic reviews comparing endovascular to best medical treatment for large-vessel occlusion acute ischaemic stroke: an umbrella review.
NIHSS
endovascular treatment
large-vessel occlusion
meta-analysis
modified Rankin scale
mortality
stroke
symptomatic intracranial haemorrhage
systematic review
Journal
Therapeutic advances in neurological disorders
ISSN: 1756-2856
Titre abrégé: Ther Adv Neurol Disord
Pays: England
ID NLM: 101480242
Informations de publication
Date de publication:
2024
2024
Historique:
received:
16
11
2023
accepted:
26
03
2024
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
30
4
2024
Statut:
epublish
Résumé
The literature on endovascular treatment (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) has been rapidly increasing after the publication of positive randomized-controlled clinical trials (RCTs) and a plethora of systematic reviews (SRs) showing benefit compared to best medical therapy (BMT) for LVO. An overview of SRs (umbrella review) and meta-analysis of primary RCTs were performed to summarize the literature and present efficacy and safety of EVT. MEDLINE Three eligible SRs and 4 additional RCTs were included in the overview, comprising a total of 24 RCTs, corresponding to 5968 AIS patients with LVO (3044 randomized to EVT In patients with AIS due to LVO in the anterior or posterior circulation, within 24 h from symptom onset, EVT improves functional outcomes and increases the chance of survival despite increased sICH risk. PROSPERO Registration Number CRD42023461138.
Sections du résumé
Background
UNASSIGNED
The literature on endovascular treatment (EVT) for large-vessel occlusion (LVO) acute ischaemic stroke (AIS) has been rapidly increasing after the publication of positive randomized-controlled clinical trials (RCTs) and a plethora of systematic reviews (SRs) showing benefit compared to best medical therapy (BMT) for LVO.
Objectives
UNASSIGNED
An overview of SRs (umbrella review) and meta-analysis of primary RCTs were performed to summarize the literature and present efficacy and safety of EVT.
Design and methods
UNASSIGNED
MEDLINE
Results
UNASSIGNED
Three eligible SRs and 4 additional RCTs were included in the overview, comprising a total of 24 RCTs, corresponding to 5968 AIS patients with LVO (3044 randomized to EVT
Conclusion
UNASSIGNED
In patients with AIS due to LVO in the anterior or posterior circulation, within 24 h from symptom onset, EVT improves functional outcomes and increases the chance of survival despite increased sICH risk.
Registration
UNASSIGNED
PROSPERO Registration Number CRD42023461138.
Identifiants
pubmed: 38685935
doi: 10.1177/17562864241246938
pii: 10.1177_17562864241246938
pmc: PMC11057347
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
17562864241246938Informations de copyright
© The Author(s), 2024.
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