A Multifunctional Herb-Derived Glycopeptide Hydrogel for Chronic Wound Healing.
Chinese herb‐derived
chronic wound
drug deliveries
glycopeptide hydrogel
immunoregulation
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
30 Apr 2024
30 Apr 2024
Historique:
revised:
12
04
2024
received:
22
01
2024
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
30
4
2024
Statut:
aheadofprint
Résumé
Chronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidized Bletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), and paeoniflorin-loaded micelles (MIC@Pae), called OBPG&MP. The hydrogel emulates the structure of glycoprotein fibers of the extracellular matrix (ECM), exhibiting exceptional injectability, self-healing, and biocompatibility. It adapts responsively to the inflammatory microenvironment of chronic wounds, sequentially releasing therapeutic agents to eradicate bacterial infection, neutralize reactive oxygen species (ROS), modulate macrophage polarization, suppress inflammation, and encourage vascular regeneration and ECM remodeling, playing a critical role across the inflammatory, proliferative, and remodeling phases of wound healing. Both in vitro and in vivo studies confirmed the efficacy of OBPG&MP hydrogel in regulating the wound microenvironment and enhancing the regeneration and remodeling of chronic wound skin tissue. This research supports the vast potential for herb-derived multifunctional hydrogels in tissue engineering and regenerative medicine.
Identifiants
pubmed: 38686688
doi: 10.1002/smll.202400516
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400516Subventions
Organisme : National Natural Science Foundation of China
ID : 82202747
Organisme : China Postdoctoral Science Foundation
ID : 2023M732459
Organisme : China Postdoctoral Science Foundation
ID : GZC20231805
Organisme : Sichuan Science and Technology Program
ID : 2023NSFSC1746
Organisme : Sichuan Science and Technology Program
ID : 2023YFS0014
Organisme : Post-Doctor Research Project, West China Hospital, Sichuan University
ID : 2023HXBH082
Organisme : Med-X Center for Manufacturing Project, Sichuan University
ID : 00402053A29VQ
Informations de copyright
© 2024 Wiley‐VCH GmbH.
Références
a) V. Falanga, R. R. Isseroff, A. M. Soulika, M. Romanelli, D. Margolis, S. Kapp, M. Granick, K. Harding, Nat. Rev. Dis. Primers. 2022, 8, 50;
b) H. Geng, X. Zheng, Y. Zhang, X. Cui, Z. Li, X. Zhang, J. Cui, F. Meng, L. Sun, S. Ni, Adv. Funct. Mater. 2023, 33, 2305154.
a) C. K. Sen, Adv. Wound Care. 2021, 10, 281;
b) M. H. Norahan, S. C. Pedroza‐González, M. G. Sánchez‐Salazar, M. M. Álvarez, G. Trujillo de Santiago, Bioact. Mater. 2023, 24, 197;
c) C. K. Sen, G. M. Gordillo, S. Roy, R. Kirsner, L. Lambert, T. K. Hunt, F. Gottrup, G. C. Gurtner, M. T. Longaker, Wound Repair Regener. 2009, 17, 763.
Y. Wang, U. Armato, J. Wu, Front. Bioengeen. Biotechnol. 2020, 8, 584.
W. Zhang, K. Zha, Y. Xiong, W. Hu, L. Chen, Z. Lin, C. Yu, W. Zhou, F. Cao, H. Hu, B. Mi, G. Liu, Bioact. Mater. 2023, 30, 29.
K. Rahim, S. Saleha, X. Zhu, L. Huo, A. Basit, O. L. Franco, Microb. Ecol. 2017, 73, 710.
a) X. Qi, Y. Huang, S. You, Y. Xiang, E. Cai, R. Mao, W. Pan, X. Tong, W. Dong, F. Ye, J. Shen, Adv. Sci. 2022, 9, 2106015;
b) N. S. Mone, S. Syed, P. Ravichandiran, E. E. Kamble, K. R. Pardesi, S. Salunke‐Gawali, M. Rai, A. Vikram Singh, S. Prasad Dakua, B.‐H. Park, D. J. Yoo, S. K. Satpute, ChemMedChem. 2023, 18, e202300328.
a) S. Wu, Y. Shuai, G. Qian, S. Peng, Z. Liu, C. Shuai, S. Yang, J. Adv. Res. 2023, 54, 239;
b) S. Sathiyavimal, S. Vasantharaj, T. Kaliannan, H. A. L. Garalleh, M. Garaleh, K. Brindhadevi, N. T. L. Chi, A. Sharma, A. Pugazhendhi, Environ. Res. 2023, 218, 114986;
c) P. Khandelwal, D. K. Singh, P. Poddar, ChemistrySelect. 2019, 4, 6719;
d) T. He, H. Chen, P. Liu, H. Shi, X. Xu, C. Feng, Y. Wang, X. Li, N. Lei, Y. Xiao, X. Zhu, J. Xu, X. Zhang, J. Mater. Sci. Technol. 2023, 163, 168;
e) P. O. Agboola, I. Shakir, J. Mater. Res. Technol. 2022, 18, 4303;
f) S. Wang, H. Zheng, L. Zhou, F. Cheng, Z. Liu, H. Zhang, L. Wang, Q. Zhang, Nano Lett. 2020, 20, 5149.
a) W. Hu, Z. Chen, X. Chen, K. Feng, T. Hu, B. Huang, J. Tang, G. Wang, S. Liu, G. Yang, Z. Wang, Carbohydr. Polym. 2023, 319, 121193;
b) Y. Wu, Y. Wang, C. Zheng, C. Hu, L. Yang, Q. Kong, H. Zhang, Y. Wang, Adv. Funct. Mater. 2023, 33, 2305992.
C. Li, J. Chen, G. Deng, P. Wang, H. Zhang, K. Zhu, Q. Hu, S. Feng, Q. Wang, H. Lin, Composites, Part B. 2023, 266, 110984.
a) Z. Zheng, J. Qi, L. Hu, D. Ouyang, H. Wang, Q. Sun, L. Lin, L. You, B. Tang, Biomater. Adv. 2022, 134, 112560;
b) F. Wang, Q. Wu, C. Zhang, L. Kong, R. Zuo, K. Feng, G. Jia, M. Hou, J. Zou, Y. Chai, J. Xu, X. Chen, Q. Kang, Small Struct. 2024, 5, 2300198.
a) P. J. Murray, Annu. Rev. Physiol. 2017, 79, 541;
b) X. Chen, L. Zhang, W. Chai, P. Tian, J. Kim, J. Ding, H. Zhang, C. Liu, D. Wang, X. Cui, H. Pan, Adv. Healthcare Mater. 2023, 12, 2301984.
N. Xu, Y. Gao, Z. Li, Y. Chen, M. Liu, J. Jia, R. Zeng, G. Luo, J. Li, Y. Yu, Chem. Eng. J. 2023, 466, 143173.
Y. Qian, Y. Zheng, J. Jin, X. Wu, K. Xu, M. Dai, Q. Niu, H. Zheng, X. He, J. Shen, Adv. Mater. 2022, 34, 2200521.
a) X. Zhou, Y. Guo, K. Yang, P. Liu, J. Wang, J. Ethnopharmacol. 2022, 282, 114662;
b) Y. Xiong, Z. Lin, P. Bu, T. Yu, Y. Endo, W. Zhou, Y. Sun, F. Cao, G. Dai, Y. Hu, L. Lu, L. Chen, P. Cheng, K. Zha, M.‐A. Shahbazi, Q. Feng, B. Mi, G. Liu, Adv. Mater. 2023, 35, 2212300;
c) J. Chi, L. Sun, L. Cai, L. Fan, C. Shao, L. Shang, Y. Zhao, Bioact. Mater. 2021, 6, 3507;
d) N. Paudel, M. Rai, S. Adhikari, A. Thapa, S. Bharati, B. Maharjan, R. L. S. Shrestha, K. Rav, A. V. Singh, J. Herbs, Spices Medic. Plants. 2024, 30, 97.
K. Gou, Y. Li, Y. Qu, H. Li, R. Zeng, Mater. Des. 2022, 223, 111198.
a) H. Yang, L. Song, B. Sun, D. Chu, L. Yang, M. Li, H. Li, Y. Dai, Z. Yu, J. Guo, Mater. Today Bio. 2021, 12, 100139;
b) T. Zhai, Y. Sun, H. Li, J. Zhang, R. Huo, H. Li, B. Shen, N. Li, J. Pharmacol. Sci. 2016, 130, 143.
a) M. Abazari, T. Akbari, M. Hasani, E. Sharifikolouei, M. Raoufi, A. Foroumadi, M. Sharifzadeh, L. Firoozpour, M. Khoobi, Carbohydr. Polym. 2022, 294, 119808;
b) M. Rai, A. V. Singh, N. Paudel, A. Kanase, E. Falletta, P. Kerkar, J. Heyda, R. F. Barghash, S. Pratap Singh, M. Soos, Curr. Res. Toxicol. 2023, 5, 100118.
a) Y. Zhang, S. Wang, Y. Yang, S. Zhao, J. You, J. Wang, J. Cai, H. Wang, J. Wang, W. Zhang, J. Yu, C. Han, Y. Zhang, Z. Gu, Nat. Commun. 2023, 14, 3431;
b) A.‐L. Gürtler, T. Rades, A. Heinz, J. Controlled Release. 2023, 363, 621;
c) J. Yang, Z. Huang, J. Tan, J. Pan, S. Chen, W. Wan, Bioact. Mater. 2024, 32, 260;
d) Y. Chen, Y. Xiang, H. Zhang, T. Zhu, S. Chen, J. Li, J. Du, X. Yan, Carbohydr. Polym. 2023, 321, 121248;
e) Y. Li, D. Hao, G. Feng, F. Xu, Matter. 2023, 6, 1060.
a) W. Li, X. Yang, P. Lai, L. Shang, Smart Med. 2022, 1, e20220024;
b) Y. Jiang, J. Wang, H. Zhang, G. Chen, Y. Zhao, Sci. Bull. 2022, 67, 1776.
a) Y. Xie, X. Shi, S. Gao, C. Lai, C. Lu, Y. Huang, D. Zhang, S. Nie, F. Xu, F. Chu, J. Mater. Chem. A. 2024, 12, 5124;
b) B. Wang, W. Zhang, C. Lai, Y. Liu, H. Guo, D. Zhang, Z. Guo, Small. 2023, 19, 2302335.
a) X. Zhang, J. Gan, L. Fan, Z. Luo, Y. Zhao, Adv. Mater. 2023, 35, 2210903;
b) G. Chen, F. Wang, X. Zhang, Y. Shang, Y. Zhao, Sci. Adv. 2023, 9, eadg3478;
c) J. Jian, Y. Xie, S. Gao, Y. Sun, C. Lai, J. Wang, C. Wang, F. Chu, D. Zhang, Carbohydr. Polym. 2022, 294, 119760.
M. Morey, A. Pandit, Adv. Drug Delivery Rev. 2018, 129, 169.
C. Yang, Y. Zhang, X. Zhang, P. Tang, T. Zheng, R. Ran, G. Li, Carbohydr. Polym. 2023, 320, 121231.
H. Xia, Z. Dong, Q. Tang, R. Ding, Y. Bai, K. Zhou, L. Wu, L. Hao, Y. He, J. Yang, H. Mao, Z. Gu, Adv. Funct. Mater. 2023, 33, 2215116.
Y. Yang, M. Li, G. Pan, J. Chen, B. Guo, Adv. Funct. Mater. 2023, 33, 2214089.
a) Y. Wang, M. Deng, Y. Wu, C. Hu, B. Zhang, C. Guo, H. Song, Q. Kong, Y. Wang, Composites, Part B. 2022, 236, 109806;
b) Q. Li, T. Wu, O. U. Akakuru, N. Song, W. Liu, W. Jiang, K. Fan, Adv. Funct. Mater. 2023, 33, 2214826.
Y. Yang, S. Zuo, J. Zhang, T. Liu, X. Li, H. Zhang, M. Cheng, S. Wang, Z. He, B. Sun, J. Sun, Nano Today. 2022, 44, 101468.
B. Sun, C. Luo, H. Yu, X. Zhang, Q. Chen, W. Yang, M. Wang, Q. Kan, H. Zhang, Y. Wang, Z. He, J. Sun, Nano Lett. 2018, 18, 3643.
a) C. Cai, H. Zhu, Y. Chen, Y. Guo, Z. Yang, H. Li, H. Liu, ACS Nano. 2022, 16, 20044;
b) S. Zhao, J. Zhang, M. Qiu, Y. Hou, X. Li, G. Zhong, K. Gou, J. Li, C. Zhang, Y. Qu, X. Wang, Int. J. Biol. Macromol. 2024, 254, 127761.
Y. Wu, Y. Wang, L. Long, C. Hu, Q. Kong, Y. Wang, J. Controlled Release. 2022, 341, 147.
L. Ding, X. Shan, X. Zhao, H. Zha, X. Chen, J. Wang, C. Cai, X. Wang, G. Li, J. Hao, G. Yu, Carbohydr. Polym. 2017, 157, 1538.
Z. Shao, T. Yin, J. Jiang, Y. He, T. Xiang, S. Zhou, Bioact. Mater. 2023, 20, 561.
J. Mao, Z. Cai, Z. Liu, S. Qian, B. Zhao, Y. Zhang, Y. Zhuang, L. Zhang, X. Mao, Y. Zhang, W. Cui, X. Sun, Chem. Eng. J. 2022, 450, 137880.
J. Xu, Y. Liu, S. Hsu, Molecules. 2019, 24, 3005
X. Zhao, D. Pei, Y. Yang, K. Xu, J. Yu, Y. Zhang, Q. Zhang, G. He, Y. Zhang, A. Li, Y. Cheng, X. Chen, Adv. Funct. Mater. 2021, 31, 2009442.
a) X. Shi, K. Wang, S. Gao, D. Zhang, C. Lai, C. Jin, M. Li, C. Wang, Q. Yong, F. Chu, Ind. Eng. Chem. Res. 2023, 62, 17765;
b) B. Yang, J. Song, Y. Jiang, M. Li, J. Wei, J. Qin, W. Peng, F. L. Lasaosa, Y. He, H. Mao, J. Yang, Z. Gu, ACS Appl. Mater. Interfaces. 2020, 12, 57782.
D. L. Taylor, M. Het Panhuis, Adv. Mater. 2016, 28, 9060.
X. Luo, L. Zhang, Y. Luo, Z. Cai, H. Zeng, T. Wang, Z. Liu, Y. Chen, X. Sheng, A. E. d. G. Mandlate, Z. Zhou, F. Chen, L. Zheng, Adv. Funct. Mater. 2023, 33, 2214036.
S. Wang, Y. Liu, Q. Sun, B. Zeng, C. Liu, L. Gong, H. Wu, L. Chen, M. Jin, J. Guo, Z. Gao, W. Huang, Adv. Sci. 2023, 10, 2303167.
Y. Chen, R. Luo, J. Li, S. Wang, J. Ding, K. Zhao, B. Lu, W. Zhou, ACS Nano. 2022, 16, 2429.
V. K. Rajan, K. Muraleedharan, Food Chem. 2017, 220, 93.
H. Chen, J. Zeng, B. Wang, Z. Cheng, J. Xu, W. Gao, K. Chen, Carbohydr. Polym. 2021, 266, 118149.
Y.‐X. Zhou, X.‐H. Gong, H. Zhang, C. Peng, Biomed. Pharmacother. 2020, 130, 110505.
T. Kim, J. Suh, W. J. Kim, Adv. Mater. 2021, 33, 2008793.
Y. Zhang, C. Zhao, X. Zhao, Y. He, Food Sci. Nutr. 2021, 9, 3250.
Y. Chen, W. Miao, X. Li, Y. Xu, H. Gao, B. Zheng, Trends Food Sci. Technol. 2023, 139, 104131.
J. Mao, L. Chen, Z. Cai, S. Qian, Z. Liu, B. Zhao, Y. Zhang, X. Sun, W. Cui, Adv. Funct. Mater. 2022, 32, 2111003.
W. Liu, R. Gao, C. Yang, Z. Feng, W. Ou‐Yang, X. Pan, P. Huang, C. Zhang, D. Kong, W. Wang, Sci. Adv. 2022, 8, eabn7006.
J. Axelsson, D. Xu, B. N. Kang, J. K. Nussbacher, T. M. Handel, K. Ley, P. Sriramarao, J. D. Esko, Blood. 2012, 120, 1742.
Z. Li, C. Wang, Y. Mao, J. Cui, X. Wang, J. Dang, S. Wang, Int. Immunopharmacol. 2021, 95, 107534.
J. Zhao, T. Di, Y. Wang, Y. Wang, X. Liu, D. Liang, P. Li, Eur. J. Pharmacol. 2016, 772, 131.
J. Liu, M. Qu, C. Wang, Y. Xue, H. Huang, Q. Chen, W. Sun, X. Zhou, G. Xu, X. Jiang, Small. 2022, 18, 2106172.
M. Rai, N. Paudel, M. Sakhrie, D. Gemmati, I. A. Khan, V. Tisato, A. Kanase, A. Schulz, A. V. Singh, Livers. 2023, 3, 448
a) R. Liu, Y. Zheng, T. Han, J. Lan, L. He, J. Shi, Am. J. Chinese Med. 2021, 49, 863;
b) J. Li, R. Li, X. Wu, C. Zheng, P. H.‐T. Shiu, P. Rangsinth, S. M.‐Y. Lee, G. P.‐H. Leung, Front. Pharmacol. 2022, 13, 928817.
Q. Yan, X. Long, P. Zhang, W. Lei, D. Sun, X. Ye, Carbohydr. Polym. 2022, 293, 119696.
Y. Pang, H. Wang, Y. Yao, D. Chen, R. Yang, Z. Wang, J. Yang, Y. Li, W. Liu, Adv. Funct. Mater. 2023, 33, 2303095.
Y. Shen, Y. Liu, J. K. Nunes, C. Wang, M. Xu, M. K. T. To, H. A. Stone, H. C. Shum, Adv. Mater. 2023, 35, 2211637.
Y.‐J. Fu, Y.‐F. Shi, L.‐Y. Wang, Y.‐F. Zhao, R.‐K. Wang, K. Li, S.‐T. Zhang, X.‐J. Zha, W. Wang, X. Zhao, W. Yang, Adv. Sci. 2023, 10, 2206771.
K. Wang, R. Dong, J. Tang, H. Li, J. Dang, Z. Zhang, Z. Yu, B. Guo, C. Yi, Chem. Eng. J. 2022, 430, 132664.