Congenital Juvenile Xanthogranuloma in the Perioral Region: A Case Image.
Congenital
Infant
Juvenile xanthogranuloma
Non-langerhans cell histiocytosis
Skin
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
30 Apr 2024
30 Apr 2024
Historique:
received:
03
04
2024
accepted:
18
04
2024
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
30
4
2024
Statut:
epublish
Résumé
Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis in childhood. It often presents with cutaneous involvement and exhibits a predilection for the head and neck region. This article illustrates a case of congenital JXG in a 5-month-old boy, characterized by a solitary, well-circumscribed nodule above the left upper lip. Histopathologically, the lesion exhibited histiocytes with eosinophilic cytoplasm and Touton giant cells. Immunohistochemistry revealed histiocytes positive for CD68 and Factor XIIIa, while negative for S-100 protein. Clinicians should become familiar with the broad clinical spectrum of cutaneous JXG, particularly its congenital presentation, in order to ensure timely and accurate management.
Identifiants
pubmed: 38687428
doi: 10.1007/s12105-024-01649-y
pii: 10.1007/s12105-024-01649-y
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Subventions
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/201.289/2022; E-26/200.331/2024
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/201.289/2022; E-26/200.331/2024
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Wee LWY, Ling HY, Ho VPY, Foong AYW, Koh MJA (2022) Juvenile xanthogranulomas in Asian children. Dermatol Ther 35(2):e15224. https://doi.org/10.1111/dth.15224
doi: 10.1111/dth.15224
pubmed: 34820973
Salari B, Dehner LP (2022) Juvenile and adult xanthogranuloma: a 30-year single-center experience and review of the disorder and its relationship to other histiocytoses. Ann Diagn Pathol 58:151940. https://doi.org/10.1016/j.anndiagpath.2022.151940
doi: 10.1016/j.anndiagpath.2022.151940
pubmed: 35378409
Dehner LP (2003) Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol 27(5):579–593. https://doi.org/10.1097/00000478-200305000-00003
doi: 10.1097/00000478-200305000-00003
pubmed: 12717244
Hernández-San Martín MJ, Vargas-Mora P, Aranibar L (2020) Juvenile xanthogranuloma: an entity with a wide clinical spectrum. Actas Dermosifiliogr 111(9):725–733. https://doi.org/10.1016/j.ad.2020.07.004
doi: 10.1016/j.ad.2020.07.004
pubmed: 32721389
Oza VS, Stringer T, Campbell C et al (2018) Congenital-type juvenile xanthogranuloma: a case series and literature review. Pediatr Dermatol 35(5):582–587. https://doi.org/10.1111/pde.13544
doi: 10.1111/pde.13544
pubmed: 29999209
Meyer SN, Vaughn A, Li Y, Studer AC, Rauen KA, Kiuru M (2023) The association between juvenile xanthogranulomas in neurofibromatosis type 1 patients and the development of leukaemia: a systematic review. J Eur Acad Dermatol Venereol 37(12):e1380–e1383. https://doi.org/10.1111/jdv.19321
doi: 10.1111/jdv.19321
pubmed: 37422708
Auerbach A, Schmieg JJ, Aguilera NS (2021) Pediatric lymphoid and histiocytic lesions in the head and neck. Head Neck Pathol 15(1):41–58. https://doi.org/10.1007/s12105-020-01257-6
doi: 10.1007/s12105-020-01257-6
pubmed: 33723759
pmcid: 7959275
Paxton CN, O’Malley DP, Bellizzi AM et al (2017) Genetic evaluation of juvenile xanthogranuloma: genomic abnormalities are uncommon in solitary lesions, advanced cases may show more complexity. Mod Pathol 30(9):1234–1240. https://doi.org/10.1038/modpathol.2017.50
doi: 10.1038/modpathol.2017.50
pubmed: 28752840
Durham BH, Lopez Rodrigo E, Picarsic J et al (2019) Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms. Nat Med 25(12):1839–1842. https://doi.org/10.1038/s41591-019-0653-6
doi: 10.1038/s41591-019-0653-6
pubmed: 31768065
pmcid: 6898787
Pai P, Nirmal A, Mathias L, Jain S, Shetty MG, Sundara BK (2024) Molecular mutations in histiocytosis: a comprehensive survey of genetic alterations. Mol Biotechnol. https://doi.org/10.1007/s12033-024-01072-2
doi: 10.1007/s12033-024-01072-2
pubmed: 38376733