Synthon Approach in Crystal Engineering to Modulate Physicochemical Properties in Organic Salts of Chlorpropamide.
bioavailability
cocrystal salt
cocrystal salt hydrate
conformational adjustment and conformational changes
crystal packing
dissolution
hydrogen bonding
pharmacokinetics
salt
solubility
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
30 Apr 2024
30 Apr 2024
Historique:
medline:
30
4
2024
pubmed:
30
4
2024
entrez:
30
4
2024
Statut:
aheadofprint
Résumé
The formulation of drug with improved bioavailability is always challenging and indispensable in the field of pharmaceutics. The control of intermolecular interactions via crystal engineering approach and solid-state molecular recognition results in the formation of active drug molecules with modulated pharmacological benefits. Therefore, with the aim to improve the solubility and dissolution rate of the drug chlorpropamide (
Identifiants
pubmed: 38688017
doi: 10.1021/acs.molpharmaceut.4c00043
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM