Feasibility of intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage.


Journal

Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884

Informations de publication

Date de publication:
30 Apr 2024
Historique:
received: 07 12 2023
accepted: 17 04 2024
revised: 15 04 2024
medline: 1 5 2024
pubmed: 1 5 2024
entrez: 30 4 2024
Statut: aheadofprint

Résumé

Intraventricular hemorrhage (IVH) is a common cause of preterm brain injury. Fresh parent's own milk (POM) contains pluripotent stem cells (SCs) that produce neuronal cells in-vitro. The permeable neonatal blood brain barrier potentially allows SC delivery. We performed the first prospective trial (clinicaltrials.gov NCT04225286) of feasibility of intranasal POM (IPOM) in preterm infants with IVH and described SC content of POM samples. 37 Infants (mean gestation 27.7 ± 2.6 weeks, birthweight 1030 ± 320 g) with IVH (35.1% grade IV) were recruited from two tertiary Toronto NICUs. IPOM was given ideally twice daily until 28 days of age. Tolerance and adverse reactions were collected and 162 administering providers surveyed. There were no major adverse reactions. Provider surveys suggested acceptability, although potential provider and subject stress requires further study. Milk cell analysis suggests wide variability between parents. This phase 1 study demonstrated IPOM was tolerated and feasible in preterm infants.

Identifiants

pubmed: 38688998
doi: 10.1038/s41372-024-01982-8
pii: 10.1038/s41372-024-01982-8
doi:

Banques de données

ClinicalTrials.gov
['NCT04225286']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Rebecca Hoban (R)

Division of Neonatology, The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada. rebecca.hoban@seattlechildrens.org.
Division of Neonatology, University of Washington, Seattle, WA, USA. rebecca.hoban@seattlechildrens.org.

Alessia Gallipoli (A)

Division of Neonatology, The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada.

Marisa Signorile (M)

Ted Rogers Computational Program, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.

Poonam Mander (P)

CReATe Fertility Centre, Toronto, ON, Canada.

Andree Gauthier-Fisher (A)

CReATe Fertility Centre, Toronto, ON, Canada.

Clifford Librach (C)

CReATe Fertility Centre, Toronto, ON, Canada.
Department of Obstetrics and Gynecology, IMS and Physiology, University of Toronto, Toronto, ON, Canada.
Sunnybrook Research Institute, Toronto, ON, Canada.

Diane Wilson (D)

Division of Neonatology, The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada.

Sharon Unger (S)

Department of Paediatrics, Izaak Walton Killam Hospital, Halifax, NS, Canada.

Classifications MeSH