Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
30 Apr 2024
Historique:
received: 01 03 2022
accepted: 11 03 2024
medline: 1 5 2024
pubmed: 1 5 2024
entrez: 30 4 2024
Statut: aheadofprint

Résumé

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10

Identifiants

DOI: 10.1038/s41588-024-01714-w PMID: 38689001
pubmed: 38689001
doi: 10.1038/s41588-024-01714-w
pii: 10.1038/s41588-024-01714-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Cornelia M van Duijn (CM)
Adam S Butterworth (AS)
Ahmad Vaez (A)
Alexander Teumer (A)
Andrew D Johnson (AD)
Andrew D Morris (AD)
Annette Peters (A)
Anuj Goel (A)
Archie Campbell (A)
Bernard D Keavney (BD)
Caroline Hayward (C)
Christopher Newton-Cheh (C)
Christopher P Nelson (CP)
Daniel I Chasman (DI)
Daniel Levy (D)
Daniela Ruggiero (D)
Eco de Geus (E)
Edith Hofer (E)
Eleftheria Zeggini (E)
Eric Boerwinkle (E)
Giorgia Girotto (G)
Helen R Warren (HR)
Hugh Watkins (H)
Ivana Kolcic (I)
J Wouter Jukema (JW)
Jennie Hui (J)
Joanna M M Howson (JMM)
Johan Sundström (J)
John C Chambers (JC)
John N Danesh (JN)
Lorenz Risch (L)
Mark J Caulfield (MJ)
Markku Laakso (M)
Martin D Tobin (MD)
Martin H De Borst (MH)
Melanie Waldenberger (M)
Nilesh J Samani (NJ)
Olle Melander (O)
Olli T Raitakari (OT)
Ozren Polašek (O)
Patricia B Munroe (PB)
Paul M Ridker (PM)
Pim van der Harst (P)
Roberto Elosua (R)
Samuli Ripatti (S)
Terho Lehtimäki (T)
William J Young (WJ)
Zoha Kamali (Z)
Zoltan Kutalik (Z)

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jacob M Keaton (JM)

Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Zoha Kamali (Z)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.
ORCID: 0000-0001-6492-5887

Tian Xie (T)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-2442-7941

Ahmad Vaez (A)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. a.vaez@umcg.nl.
Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. a.vaez@umcg.nl.
ORCID: 0000-0001-9048-3795

Ariel Williams (A)

Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Slavina B Goleva (SB)

Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0001-5177-9286

Alireza Ani (A)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.
ORCID: 0000-0002-7868-3118

Evangelos Evangelou (E)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Ioannina, Greece.
ORCID: 0000-0002-5488-2999

Jacklyn N Hellwege (JN)

Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0001-7479-0920

Loic Yengo (L)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

William J Young (WJ)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
ORCID: 0000-0002-9831-6817

Matthew Traylor (M)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.

Ayush Giri (A)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.

Zhili Zheng (Z)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
ORCID: 0000-0003-2102-221X

Jian Zeng (J)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

Daniel I Chasman (DI)

Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Andrew P Morris (AP)

Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
ORCID: 0000-0002-6805-6014

Mark J Caulfield (MJ)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0001-9295-3594

Shih-Jen Hwang (SJ)

Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University, Boston, MA, USA.

Jaspal S Kooner (JS)

National Heart and Lung Institute, Imperial College London, London, UK.
ORCID: 0000-0003-2086-4837

David Conen (D)

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

John R Attia (JR)

Faculty of Health and Medicine, University of Newcastle, New Lambton Heights, Newcastle, New South Wales, Australia.
ORCID: 0000-0001-9800-1308

Alanna C Morrison (AC)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
ORCID: 0000-0001-6381-4296

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-8532-5087

Kati Kristiansson (K)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

Reinhold Schmidt (R)

Department of Neurology/Medical University Graz, Graz, Austria.

Andrew A Hicks (AA)

Institute for Biomedicine, Eurac Research, Bolzano, Italy.
University of Lübeck, Lübeck, Germany.
ORCID: 0000-0001-6320-0411

Peter P Pramstaller (PP)

Institute for Biomedicine, Eurac Research, Bolzano, Italy.
University of Lübeck, Lübeck, Germany.
ORCID: 0000-0002-9831-8302

Christopher P Nelson (CP)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Leicester, UK.

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Leicester, UK.

Lorenz Risch (L)

Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
Department of Laboratory Medicine, Dr. Risch Anstalt, Vaduz, Liechtenstein.
ORCID: 0000-0003-2692-6699

Ulf Gyllensten (U)

Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-6316-3355

Olle Melander (O)

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.

Harriette Riese (H)

Interdisciplinary Center Psychopathology and Emotional Regulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

James F Wilson (JF)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
ORCID: 0000-0001-5751-9178

Harry Campbell (H)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0003-3872-7793

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-7278-2190

Yingchang Lu (Y)

Vanderbilt Genetic Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0002-5264-5068

Kenneth M Rice (KM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3071-7278

Peter Vollenweider (P)

Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Johan Sundström (J)

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
ORCID: 0000-0002-5017-7344

Martin D Tobin (MD)

Department of Health Sciences, University of Leicester, Leicester, UK.
Leicester NIHR Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
ORCID: 0000-0002-3596-7874

Vilmantas Giedraitis (V)

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-3423-2021

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3137-6337

Jaakko Tuomilehto (J)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health, University of Helsinki, Helsinki, Finland.
Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.

Zoltan Kutalik (Z)

Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Samuli Ripatti (S)

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-0504-1202

Veikko Salomaa (V)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0001-7563-5324

Giorgia Girotto (G)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.
ORCID: 0000-0003-4507-6589

Stella Trompet (S)

Department Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0001-5006-0528

J Wouter Jukema (JW)

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Netherlands Heart Institute, Utrecht, the Netherlands.

Pim van der Harst (P)

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Paul M Ridker (PM)

Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Franco Giulianini (F)

Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.

Veronique Vitart (V)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
ORCID: 0000-0002-4991-3797

Anuj Goel (A)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0003-2307-4021

Hugh Watkins (H)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0002-5287-9016

Sarah E Harris (SE)

Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-4941-5106

Ian J Deary (IJ)

Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-1733-263X

Peter J van der Most (PJ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-8450-3518

Albertine J Oldehinkel (AJ)

Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-3925-3913

Bernard D Keavney (BD)

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Manchester Heart Institute, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
ORCID: 0000-0001-9573-0812

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-9405-9550

Archie Campbell (A)

Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.
Usher Institute, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0003-0198-5078

Michael Boehnke (M)

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Laura J Scott (LJ)

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-4886-5084

Thibaud Boutin (T)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
ORCID: 0000-0003-4754-1675

Chrysovalanto Mamasoula (C)

Population Health Sciences Institute, Newcastle University, Newcastle, UK.

Marjo-Riitta Järvelin (MR)

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lehrstuhl für Epidemiologie, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Neuherberg, Germany.
ORCID: 0000-0001-6645-0985

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
ORCID: 0000-0001-6986-9554

Edward G Lakatta (EG)

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
ORCID: 0000-0002-4772-0035

Francesco Cucca (F)

Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Italy.
ORCID: 0000-0002-7414-1995

Jennie Hui (J)

Busselton Population Medical Research Institute, Perth, Western Australia, Australia.
School of Population and Global Health, The University of Western Australia, Nedlands, Western Australia, Australia.

Paul Knekt (P)

Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

Stefan Enroth (S)

Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-5056-9137

Martin H De Borst (MH)

Department of Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-4127-8733

Ozren Polašek (O)

University of Split School of Medicine, Split, Croatia.
Algebra University College, Zagreb, Croatia.

Maria Pina Concas (MP)

Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.

Eulalia Catamo (E)

Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.
ORCID: 0000-0002-4701-9134

Massimiliano Cocca (M)

Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.
ORCID: 0000-0002-1127-7596

Ruifang Li-Gao (R)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Edith Hofer (E)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Helena Schmidt (H)

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
ORCID: 0000-0001-9773-9992

Beatrice Spedicati (B)

Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
ORCID: 0000-0002-7432-4708

Melanie Waldenberger (M)

Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0003-0583-5093

David P Strachan (DP)

Population Health Sciences Institute St George's, University of London, London, UK.

Maris Laan (M)

Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-8519-243X

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8309-094X

Marcus Dörr (M)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.

Vilmundur Gudnason (V)

Icelandic Heart Association, Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, Kopavogur, Iceland.
ORCID: 0000-0001-5696-0084

James P Cook (JP)

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Daniela Ruggiero (D)

IRCCS Neuromed, Pozzilli, Italy.
Institute of Genetics and Biophysics - 'A. Buzzati-Traverso', National Research Council of Italy, Naples, Italy.
ORCID: 0000-0003-3898-7827

Ivana Kolcic (I)

Algebra University College, Zagreb, Croatia.
Department of Public Health, University of Split School of Medicine, Split, Croatia.
ORCID: 0000-0001-7918-6052

Eric Boerwinkle (E)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

Michela Traglia (M)

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Olli T Raitakari (OT)

Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

Andrew D Johnson (AD)

Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.
The Framingham Heart Study, Framingham, MA, USA.
ORCID: 0000-0001-6369-5178

Christopher Newton-Cheh (C)

Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-3001-9111

Morris J Brown (MJ)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0001-8409-1082

Anna F Dominiczak (AF)

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
ORCID: 0000-0003-4913-3608

Peter J Sever (PJ)

International Centre for Circulatory Health, Imperial College London, London, UK.

Neil Poulter (N)

School of Public Health, Imperial College London, London, UK.

John C Chambers (JC)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.
ORCID: 0000-0003-0209-4541

Roberto Elosua (R)

Hospital del Mar Research Institute (IMIM), Barcelona, Spain.
CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain.
Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.

David Siscovick (D)

New York Academy of Medicine, New York, NY, USA.

Tõnu Esko (T)

Institute of Genomics, University of Tartu, Tartu, Estonia.

Andres Metspalu (A)

Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-3718-796X

Rona J Strawbridge (RJ)

Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Health Data Research UK, Glasgow, UK.
Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-8506-3585

Markku Laakso (M)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Kuopio University Hospital, Kuopio, Finland.
ORCID: 0000-0002-3394-7749

Anders Hamsten (A)

Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Jouke-Jan Hottenga (JJ)

Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
ORCID: 0000-0002-5668-2368

Eco de Geus (E)

Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, Amsterdam, the Netherlands.

Andrew D Morris (AD)

Data Science, University of Edinburgh, Edinburgh, UK.
Health Data Research UK, London, UK.

Colin N A Palmer (CNA)

Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
ORCID: 0000-0002-6415-6560

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-5047-4077

Yuri Milaneschi (Y)

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
ORCID: 0000-0002-3697-6617

Jonathan Marten (J)

Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.

Alan Wright (A)

Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.

Eleftheria Zeggini (E)

Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany.
ORCID: 0000-0003-4238-659X

Joanna M M Howson (JMM)

Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-7618-0050

Christopher J O'Donnell (CJ)

VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tim Spector (T)

Department of Twin Research, King's College London, London, UK.
ORCID: 0000-0002-9795-0365

Mike A Nalls (MA)

Center for Alzheimer's and Related Dementias, NIA/NINDS, NIH, Bethesda, MD, USA.
Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA.
DataTecnica LLC, Washington, DC, USA.
ORCID: 0000-0003-0319-4325

Eleanor M Simonsick (EM)

Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

Yongmei Liu (Y)

Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.

Cornelia M van Duijn (CM)

Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
ORCID: 0000-0002-2374-9204

Adam S Butterworth (AS)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-6915-9015

John N Danesh (JN)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.
Department of Human Genetics, The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.

Cristina Menni (C)

Department of Twin Research and Genetic Epidemiology, London, UK.
ORCID: 0000-0001-9790-0571

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Yan V Sun (YV)

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
VA Atlanta Healthcare System, Decatur, GA, USA.
ORCID: 0000-0002-2838-1824

Peter W F Wilson (PWF)

Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
ORCID: 0000-0002-5653-7056

Kelly Cho (K)

Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.

Peter M Visscher (PM)

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0002-2143-8760

Joshua C Denny (JC)

Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-3049-7332

Daniel Levy (D)

Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

Todd L Edwards (TL)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. todd.l.edwards@vumc.org.
ORCID: 0000-0003-4318-6119

Patricia B Munroe (PB)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0002-4176-2947

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-1949-2298

Helen R Warren (HR)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.
ORCID: 0000-0003-0511-1386

Classifications MeSH