A long journey to the colon: The role of the small intestine microbiota in intestinal disease.
diet
gut microbiota
host‐microbiota‐pathogen interactions
intestinal disease
small intestine
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
01 May 2024
01 May 2024
Historique:
revised:
09
04
2024
received:
03
03
2024
accepted:
17
04
2024
medline:
1
5
2024
pubmed:
1
5
2024
entrez:
1
5
2024
Statut:
aheadofprint
Résumé
The small intestine represents a complex and understudied gut niche with significant implications for human health. Indeed, many infectious and non-infectious diseases center within the small intestine and present similar clinical manifestations to large intestinal disease, complicating non-invasive diagnosis and treatment. One major neglected aspect of small intestinal diseases is the feedback relationship with the resident collection of commensal organisms, the gut microbiota. Studies focused on microbiota-host interactions in the small intestine in the context of infectious and non-infectious diseases are required to identify potential therapeutic targets dissimilar from those used for large bowel diseases. While sparsely populated, the small intestine represents a stringent commensal bacterial microenvironment the host relies upon for nutrient acquisition and protection against invading pathogens (colonization resistance). Indeed, recent evidence suggests that disruptions to host-microbiota interactions in the small intestine impact enteric bacterial pathogenesis and susceptibility to non-infectious enteric diseases. In this review, we focus on the microbiota's impact on small intestine function and the pathogenesis of infectious and non-infectious diseases of the gastrointestinal (GI) tract. We also discuss gaps in knowledge on the role of commensal microorganisms in proximal GI tract function during health and disease.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Howard Hughes Medical Institute
ID : GT15104
Pays : United States
Organisme : NIH HHS
ID : P30 058404
Pays : United States
Organisme : NIH HHS
ID : P50CA236733
Pays : United States
Organisme : NIH HHS
ID : R01 AI168302
Pays : United States
Organisme : NIH HHS
ID : R01DK131104
Pays : United States
Organisme : NIH HHS
ID : T32ES007028-46
Pays : United States
Informations de copyright
© 2024 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.
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