Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum.
Caesarean section scar diverticulum
bacterial
fungi
human
infertility
inflammation
medicine
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 May 2024
01 May 2024
Historique:
medline:
1
5
2024
pubmed:
1
5
2024
entrez:
1
5
2024
Statut:
epublish
Résumé
Caesarean section scar diverticulum (CSD) is a significant cause of infertility among women who have previously had a Caesarean section, primarily due to persistent inflammatory exudation associated with this condition. Even though abnormal bacterial composition is identified as a critical factor leading to this chronic inflammation, clinical data suggest that a long-term cure is often unattainable with antibiotic treatment alone. In our study, we employed metagenomic analysis and mass spectrometry techniques to investigate the fungal composition in CSD and its interaction with bacteria. We discovered that local fungal abnormalities in CSD can disrupt the stability of the bacterial population and the entire microbial community by altering bacterial abundance via specific metabolites. For instance,
Identifiants
pubmed: 38690990
doi: 10.7554/eLife.90363
pii: 90363
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of Guangdong Province
ID : 2023A1515012940
Organisme : Guangdong Basic and Applied Basic Research Foundation
ID : 2023A1515110325
Organisme : Postdoctoral Fellowship Program of CPSF
ID : GZC20233216
Informations de copyright
© 2023, Chen, Chen et al.
Déclaration de conflit d'intérêts
PC, HC, ZL, XP, QL, XY No competing interests declared
Références
Microbiol Spectr. 2022 Aug 31;10(4):e0167622
pubmed: 35900092
Virulence. 2017 Apr 3;8(3):342-351
pubmed: 27657355
Br Med J. 1959 Nov 21;2(5159):1058-61
pubmed: 14433672
Bioinformatics. 2001 Mar;17(3):282-3
pubmed: 11294794
Lancet Glob Health. 2015 Apr 27;3 Suppl 2:S28-37
pubmed: 25926318
Nat Microbiol. 2021 Jan;6(1):87-102
pubmed: 33139882
Hum Reprod. 2013 Jul;28(7):1943-52
pubmed: 23644593
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
NPJ Biofilms Microbiomes. 2019 Dec 20;5(1):37
pubmed: 31885873
Front Med (Lausanne). 2021 Nov 22;8:651938
pubmed: 34881249
Hum Reprod Update. 2018 Jul 1;24(4):393-415
pubmed: 29668899
BMC Bioinformatics. 2010 Mar 08;11:119
pubmed: 20211023
Nat Rev Endocrinol. 2016 Nov;12(11):654-667
pubmed: 27448058
Front Genet. 2022 Jan 04;12:803627
pubmed: 35058973
Innovation (Camb). 2023 Feb 02;4(2):100388
pubmed: 36895758
Bioinformatics. 2015 May 15;31(10):1674-6
pubmed: 25609793
Cell Rep Med. 2022 Aug 16;3(8):100713
pubmed: 35932762
Arch Gynecol Obstet. 2022 Jul;306(1):229-237
pubmed: 35347382
PLoS Pathog. 2010 Jan 08;6(1):e1000713
pubmed: 20072605
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Bioinformatics. 2014 Nov 1;30(21):3123-4
pubmed: 25061070
Front Microbiol. 2023 Mar 22;14:1137869
pubmed: 37032888
Hum Reprod. 2013 Jun;28(6):1489-96
pubmed: 23585560
Bioinformatics. 2010 Sep 15;26(18):2342-4
pubmed: 20628077
J Minim Invasive Gynecol. 2013 Sep-Oct;20(5):562-72
pubmed: 23680518
Cell Host Microbe. 2011 Oct 20;10(4):311-23
pubmed: 22018232
Science. 2012 Jun 8;336(6086):1268-73
pubmed: 22674334
PLoS Med. 2018 Jan 23;15(1):e1002494
pubmed: 29360829
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Nat Methods. 2015 Jan;12(1):59-60
pubmed: 25402007
Clin Microbiol Rev. 2021 Dec 15;34(4):e0032320
pubmed: 34259567
Hum Reprod Update. 2019 May 1;25(3):298-325
pubmed: 30938752
Microbiome. 2020 Nov 23;8(1):166
pubmed: 33228810