Post-diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.
colorectal cancer survival
evidence grading
meta‐analysis
physical activity
systematic review
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 May 2024
01 May 2024
Historique:
revised:
15
12
2023
received:
21
07
2023
accepted:
17
01
2024
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
1
5
2024
Statut:
aheadofprint
Résumé
Low physical activity and high sedentary behaviour have been clearly linked with colorectal cancer development, yet data on their potential role in colorectal cancer survival is limited. Better characterisation of these relationships is needed for the development of post-diagnosis physical activity and sedentary behaviour guidance for colorectal cancer survivors. We searched PubMed and Embase through 28 February 2022 for studies assessing post-diagnosis physical activity, and/or sedentary behaviour in relation to all-cause and cause-specific mortality and recurrence after colorectal cancer diagnosis. Total and recreational physical activity were assessed overall and by frequency, duration, intensity, and volume using categorical, linear, and non-linear dose-response random-effects meta-analyses. The Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel interpreted and graded the likelihood of causality. We identified 16 observational studies on 82,220 non-overlapping patients from six countries. Physical activity was consistently inversely associated with colorectal cancer morbidity and mortality outcomes, with 13%-60% estimated reductions in risk. Sedentary behaviour was positively associated with all-cause mortality. The evidence had methodological limitations including potential confounding, selection bias and reverse causation, coupled with a limited number of studies for most associations. The CUP Global Expert panel concluded limited-suggestive evidence for recreational physical activity with all-cause mortality and cancer recurrence. Total physical activity and its specific domains and dimensions, and sedentary behaviour were all graded as limited-no conclusion for all outcomes. Future research should focus on randomised trials, while observational studies should obtain objective and repeated physical activity measures and better adjustment for confounders.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Cancer Research Fund
Organisme : Wereld Kanker Onderzoek Fonds
Organisme : American Institute for Cancer Research
Informations de copyright
© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
Références
Morgan E, Arnold M, Gini A, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023;72:338‐344.
Gini A, Jansen EEL, Zielonke N, et al. Impact of colorectal cancer screening on cancer‐specific mortality in Europe: a systematic review. Eur J Cancer. 2020;127:224‐235.
Lin JS, Piper MA, Perdue LA, et al. Screening for colorectal cancer: updated evidence report and systematic review for the US preventive services task force. Jama. 2016;315:2576‐2594.
Lin JS, Perdue LA, Henrikson NB, Bean SI, Blasi PR. Screening for colorectal cancer: updated evidence report and systematic review for the US preventive services task force. Jama. 2021;325:1978‐1998.
Allemani C, Matsuda T, Di Carlo V, et al. Global surveillance of trends in cancer survival 2000–14 (CONCORD‐3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population‐based registries in 71 countries. Lancet. 2018;391:1023‐1075.
American Cancer Society—Colorectal Cancer Survival Rates. Accessed March 2023. https://www.cancer.org/cancer/colon-rectal-cancer/detection-diagnosis-staging/survival-rates.html
Araghi M, Arnold M, Rutherford MJ, et al. Colon and rectal cancer survival in seven high‐income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK‐2 project). Gut. 2021;70:114‐126.
Soerjomataram I, Cabasag C, Bardot A, et al. Cancer survival in Africa, central and south America, and Asia (SURVCAN‐3): a population‐based benchmarking study in 32 countries. Lancet Oncol. 2023;24:22‐32.
World Cancer Research Fund/American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Continuous Update Project Expert Report. 2018. Accessed March 2023. http://dietandcancerreport.org
Rezende LFM, Sá TH, Markozannes G, et al. Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases. Br J Sports Med. 2018;52:826‐833.
McTiernan A, Friedenreich CM, Katzmarzyk PT, et al. Physical activity in cancer prevention and survival: a systematic review. Med Sci Sports Exerc. 2019;51:1252‐1261.
Je Y, Jeon JY, Giovannucci EL, Meyerhardt JA. Association between physical activity and mortality in colorectal cancer: a meta‐analysis of prospective cohort studies. Int J Cancer. 2013;133:1905‐1913.
Des Guetz G, Uzzan B, Bouillet T, et al. Impact of physical activity on cancer‐specific and overall survival of patients with colorectal cancer. Gastroenterol Res Pract. 2013;2013:340851.
Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta‐analysis. Ann Oncol. 2014;25:1293‐1311.
Otto SJ, Korfage IJ, Polinder S, et al. Association of change in physical activity and body weight with quality of life and mortality in colorectal cancer: a systematic review and meta‐analysis. Support Care Cancer. 2015;23:1237‐1250.
Friedenreich CM, Neilson HK, Farris MS, Courneya KS. Physical activity and cancer outcomes: a precision medicine approach. Clin Cancer Res. 2016;22:4766‐4775.
Wu W, Guo F, Ye J, et al. Pre‐ and post‐diagnosis physical activity is associated with survival benefits of colorectal cancer patients: a systematic review and meta‐analysis. Oncotarget. 2016;7:52095‐52103.
Qiu S, Jiang C, Zhou L. Physical activity and mortality in patients with colorectal cancer: a meta‐analysis of prospective cohort studies. Eur J Cancer Prev. 2020;29:15‐26.
Courneya KS, Vardy JL, O'Callaghan CJ, et al. Effects of a structured exercise program on physical activity and fitness in colon cancer survivors: one year feasibility results from the CHALLENGE trial. Cancer Epidemiol Biomark Prev. 2016;25:969‐977.
Tremblay MS, Aubert S, Barnes JD, et al. Sedentary Behavior Research Network (SBRN)—terminology consensus project process and outcome. Int J Behav Nutr Phys Act. 2017;14:75.
Swain CTV, Nguyen NH, Eagles T, et al. Postdiagnosis sedentary behavior and health outcomes in cancer survivors: a systematic review and meta‐analysis. Cancer. 2020;126:861‐869.
Patel AV, Friedenreich CM, Moore SC, et al. American College of Sports Medicine roundtable report on physical activity, sedentary behavior, and cancer prevention and control. Med Sci Sports Exerc. 2019;51:2391‐2402.
Campbell KL, Winters‐Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51:2375‐2390.
Rock CL, Thomson CA, Sullivan KR, et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin. 2022;72:230‐262.
WHO guidelines on physical activity and sedentary behaviour. Accessed March 2023. https://www.who.int/publications/i/item/9789240015128
Physical Activity Guidelines for Americans. 2018. Accessed March 2023. https://health.gov/sites/default/files/2019‐09/Physical_Activity_Guidelines_2nd_edition.pdf,
Global Cancer Update Programme (CUP Global). Accessed March 2023. https://www.wcrf.org/diet‐activity‐and‐cancer/global‐cancer‐update‐programme/about‐the‐global‐cancer‐update‐programme/
Becerra‐Tomás N, Markozannes G, Cariolou M, et al. Post‐diagnosis adiposity and colorectal cancer prognosis: a Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis. Int J Cancer. 2024.
Chan DSM, Cariolou M, Markozannes G, et al. Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: a Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis. Int J Cancer. 2024.
Tsilidis KK, Markozannes G, Becerra‐Tomás N, et al. Post‐diagnosis adiposity, physical activity, sedentary behaviour, dietary factors, supplement use and colorectal cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading. Int J Cancer. 2024.
Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160.
Chan DSM, Tsilidis K, Becerra‐Tomas N, et al. Global Cancer Update Programme Protocol for the data collection and systematic literature review on the role of diet, body fatness and physical activity on survival after colorectal cancer. Accessed December 2023. https://osf.io/r5ud2/registrations
DerSimonian R, Laird N. Meta‐analysis in clinical trials. Control Clin Trials. 1986;7:177‐188.
Orsini N. Weighted mixed‐effects dose–response models for tables of correlated contrasts. Stata J. 2021;21:320‐347.
Royston P. A strategy for modelling the effect of a continuous covariate in medicine and epidemiology. Stat Med. 2000;19:1831‐1847.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. BMJ. 1997;315:629‐634.
Duval S, Tweedie R. Trim and fill: a simple funnel‐plot‐based method of testing and adjusting for publication bias in meta‐analysis. Biometrics. 2000;56:455‐463.
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta‐analysis. Stat Med. 2002;21:1539‐1558.
Borenstein M, Higgins JP, Hedges LV, Rothstein HR. Basics of meta‐analysis: I(2) is not an absolute measure of heterogeneity. Res Synth Methods. 2017;8:5‐18.
Viechtbauer W, Cheung MW. Outlier and influence diagnostics for meta‐analysis. Res Synth Methods. 2010;1:112‐125.
USDA. Nutrition Evidence Systematic Review. Risk of Bias for Nutrition Observational Studies (RoB‐NObs) Tool. Accessed November 2022. https://nesr.usda.gov/sites/default/files/2019-07/RiskOfBiasForNutritionObservationalStudies-RoB-NObs.pdf
Sterne JA, Hernán MA, Reeves BC, et al. ROBINS‐I: a tool for assessing risk of bias in non‐randomised studies of interventions. BMJ. 2016;355:i4919.
Adams SV, Ceballos R, Newcomb PA. Quality of life and mortality of long‐term colorectal cancer survivors in the Seattle Colorectal Cancer Family Registry. PLoS One. 2016;11:e0156534.
Agalar C, Sokmen S, Arslan C, et al. The impact of sarcopenia on morbidity and long‐term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10‐year longitudinal analysis of a single‐center experience. Tech Coloproctol. 2020;24:301‐308.
Araújo RF Jr, Lira GA, Guedes HG, et al. Lifestyle and family history influence cancer prognosis in Brazilian individuals. Pathol Res Pract. 2013;209:753‐757.
Arnold M, Charvat H, Freisling H, et al. Adult overweight and survival from breast and colorectal cancer in Swedish women. Cancer Epidemiol Biomark Prev. 2019;28:1518‐1524.
Baker JR, Umesh S, Jenab M, et al. Prediagnostic blood selenium status and mortality among patients with colorectal cancer in Western European populations. Biomedicine. 2021;9:9.
Campbell PT, Newton CC, Newcomb PA, et al. Association between body mass index and mortality for colorectal cancer survivors: overall and by tumor molecular phenotype. Cancer Epidemiol Biomark Prev. 2015;24:1229‐1238.
Cannioto RA, Dighe S, Mahoney MC, et al. Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository. Cancer Causes Control. 2019;30:1‐12.
Carr PR, Banbury BL, Berndt SI, et al. Association between intake of red and processed meat and survival in patients with colorectal cancer in a pooled analysis. Clin Gastroenterol Hepatol. 2019;17:1561‐1570.e3.
Carr PR, Jansen L, Walter V, et al. Associations of red and processed meat with survival after colorectal cancer and differences according to timing of dietary assessment. Am J Clin Nutr. 2016;103:192‐200.
Cespedes Feliciano EM, Hohensee C, Rosko AE, et al. Association of prediagnostic frailty, change in frailty status, and mortality after cancer diagnosis in the Women's Health Initiative. JAMA Netw Open. 2020;3:e2016747.
Cespedes Feliciano EM, Prentice RL, Aragaki AK, et al. Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: the example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative. Int J Cancer. 2017;141:2281‐2290.
Charvat H, Freisling H, Noh H, et al. Excess body fatness during early to mid‐adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. Cancer Epidemiol Biomark Prev. 2022;31:325‐333.
Daniel CR, Shu X, Ye Y, et al. Severe obesity prior to diagnosis limits survival in colorectal cancer patients evaluated at a large cancer centre. Br J Cancer. 2016;114:103‐109.
Diao XY, Peng T, Kong FG, et al. Alcohol consumption promotes colorectal cancer by altering intestinal permeability. Eur Rev Med Pharmacol Sci. 2020;24:9370‐9377.
Dik VK, Murphy N, Siersema PD, et al. Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival—results from the EPIC cohort study. Cancer Epidemiol Biomark Prev. 2014;23:1813‐1823.
Doria‐Rose VP, Newcomb PA, Morimoto LM, Hampton JM, Trentham‐Dietz A. Body mass index and the risk of death following the diagnosis of colorectal cancer in postmenopausal women (United States). Cancer Causes Control. 2006;17:63‐70.
Fedirko V, Riboli E, Tjønneland A, et al. Prediagnostic 25‐hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European populations. Cancer Epidemiol Biomark Prev. 2012;21:582‐593.
Fedirko V, Romieu I, Aleksandrova K, et al. Pre‐diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. Int J Cancer. 2014;135:1949‐1960.
Galas A, Kulig J. Low‐grade dietary‐related inflammation and survival after colorectal cancer surgery. J Cancer Res Clin Oncol. 2014;140:1517‐1525.
Gibbs DC, Bostick RM, McCullough ML, et al. Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D‐binding protein isoforms. Int J Cancer. 2020;147:2725‐2734.
Gibson TM, Park Y, Robien K, et al. Body mass index and risk of second obesity‐associated cancers after colorectal cancer: a pooled analysis of prospective cohort studies. J Clin Oncol. 2014;32:4004‐4011.
Hardikar S, Newcomb PA, Campbell PT, et al. Prediagnostic physical activity and colorectal cancer survival: overall and stratified by tumor characteristics. Cancer Epidemiol Biomark Prev. 2015;24:1130‐1137.
Haydon AM, Macinnis RJ, English DR, Giles GG. Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut. 2006;55:62‐67.
Haydon AM, Macinnis RJ, English DR, Morris H, Giles GG. Physical activity, insulin‐like growth factor 1, insulin‐like growth factor binding protein 3, and survival from colorectal cancer. Gut. 2006;55:689‐694.
Jacobs S, Harmon BE, Ollberding NJ, et al. Among 4 diet quality indexes, only the alternate Mediterranean diet score is associated with better colorectal cancer survival and only in African American women in the multiethnic cohort. J Nutr. 2016;146:1746‐1755.
Jayasekara H, English DR, Haydon A, et al. Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype. Int J Cancer. 2018;142:238‐250.
Je Y, Lee JE, Ma J, et al. Prediagnostic plasma vitamin B6 (pyridoxal 5′‐phosphate) and survival in patients with colorectal cancer. Cancer Causes Control. 2013;24:719‐729.
Jeffreys M, Redaniel MT, Martin RM. The effect of pre‐diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink. BMC Cancer. 2015;15:670.
Kocarnik JM, Chan AT, Slattery ML, et al. Relationship of prediagnostic body mass index with survival after colorectal cancer: stage‐specific associations. Int J Cancer. 2016;139:1065‐1072.
Kyrø C, Frederiksen K, Holm M, et al. Prediagnosis plasma concentrations of enterolactone and survival after colorectal cancer: the Danish Diet, Cancer and Health cohort. Br J Nutr. 2019;122:552‐563.
Laake I, Larsen IK, Selmer R, Thune I, Veierød MB. Pre‐diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population‐based cohort study. BMC Cancer. 2016;16:402.
Lewis C, Xun P, Fly AD, Luo J, He K. Fish oil supplementation and quality of life in stage II colorectal cancer patients: a 24‐month follow‐up study. Nutr Cancer. 2015;67:1239‐1246.
Mao Z, Aglago EK, Zhao Z, et al. Dietary intake of advanced glycation end products (AGEs) and mortality among individuals with colorectal cancer. Nutrients. 2021;13:4435.
Ng K, Meyerhardt JA, Wu K, et al. Circulating 25‐hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008;26:2984‐2991.
Ogino S, Shima K, Nosho K, et al. A cohort study of p27 localization in colon cancer, body mass index, and patient survival. Cancer Epidemiol Biomark Prev. 2009;18:1849‐1858.
Oyeyemi SO, Braaten T, Skeie G, Borch KB. Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study. BMJ Open Gastroenterol. 2019;6:e000338.
Park SM, Lim MK, Shin SA, Yun YH. Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study. J Clin Oncol. 2006;24:5017‐5024.
Park SM, Yun YH, Kim YA, et al. Prediagnosis body mass index and risk of secondary primary cancer in male cancer survivors: a large cohort study. J Clin Oncol. 2016;34:4116‐4124.
Patel SA, Chen YH, Hornick JL, et al. Early‐stage rectal cancer: clinical and pathologic prognostic markers of time to local recurrence and overall survival after resection. Dis Colon Rectum. 2014;57:449‐459.
Pelser C, Arem H, Pfeiffer RM, et al. Prediagnostic lifestyle factors and survival after colon and rectal cancer diagnosis in the National Institutes of Health (NIH)‐AARP Diet and Health Study. Cancer. 2014;120:1540‐1547.
Prizment AE, Flood A, Anderson KE, Folsom AR. Survival of women with colon cancer in relation to precancer anthropometric characteristics: the Iowa Women's Health Study. Cancer Epidemiol Biomark Prev. 2010;19:2229‐2237.
Reichle K, Peter RS, Concin H, Nagel G. Associations of pre‐diagnostic body mass index with overall and cancer‐specific mortality in a large Austrian cohort. Cancer Causes Control. 2015;26:1643‐1652.
Romaguera D, Ward H, Wark PA, et al. Pre‐diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study. BMC Med. 2015;13:107.
Sharma I, Roebothan B, Zhu Y, et al. Hypothesis and data‐driven dietary patterns and colorectal cancer survival: findings from Newfoundland and Labrador colorectal cancer cohort. Nutr J. 2018;17:55.
Skeie G, Braaten T, Olsen A, et al. Whole grain intake and survival among Scandinavian colorectal cancer patients. Nutr Cancer. 2014;66:6‐13.
Slattery ML, Anderson K, Samowitz W, et al. Hormone replacement therapy and improved survival among postmenopausal women diagnosed with colon cancer (USA). Cancer Causes Control. 1999;10:467‐473.
Slattery ML, French TK, Egger MJ, Lyon JL. Diet and survival of patients with colon cancer in Utah: is there an association? Int J Epidemiol. 1989;18:792‐797.
Stapley S, Peters TJ, Sharp D, Hamilton W. The mortality of colorectal cancer in relation to the initial symptom at presentation to primary care and to the duration of symptoms: a cohort study using medical records. Br J Cancer. 2006;95:1321‐1325.
Sun H, Liu Y, Huang H, Li D, Zhao Y. Diet quality score and survival rate in patients with colorectal cancer. Asia Pac J Clin Nutr. 2019;28:601‐606.
Walter V, Jansen L, Knebel P, Chang‐Claude J, Hoffmeister M, Brenner H. Physical activity and survival of colorectal cancer patients: population‐based study from Germany. Int J Cancer. 2017;140:1985‐1997.
Walter V, Jansen L, Ulrich A, et al. Alcohol consumption and survival of colorectal cancer patients: a population‐based study from Germany. Am J Clin Nutr. 2016;103:1497‐1506.
Wang N, Khankari NK, Cai H, et al. Prediagnosis body mass index and waist‐hip circumference ratio in association with colorectal cancer survival. Int J Cancer. 2017;140:292‐301.
Ward HA, Norat T, Overvad K, et al. Pre‐diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition. Br J Nutr. 2016;116:316‐325.
Weinstein SJ, Mondul AM, Yu K, et al. Circulating 25‐hydroxyvitamin D up to 3 decades prior to diagnosis in relation to overall and organ‐specific cancer survival. Eur J Epidemiol. 2018;33:1087‐1099.
Wolpin BM, Wei EK, Ng K, et al. Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol. 2008;26:3222‐3228.
Xia S, Sun M, Liu X. Major depression but not minor to intermediate depression correlates with unfavorable prognosis in surgical colorectal cancer patients underwent adjuvant chemotherapy. Psychol Health Med. 2020;25:309‐318.
Yang Y, Mauldin PD, Ebeling M, et al. Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients. Cancer. 2013;119:1512‐1520.
Yuan C, Song M, Zhang Y, et al. Prediagnostic circulating concentrations of vitamin D binding protein and survival among patients with colorectal cancer. Cancer Epidemiol Biomark Prev. 2020;29:2323‐2331.
Zamora‐Ros R, Guinó E, Alonso MH, et al. Dietary flavonoids, lignans and colorectal cancer prognosis. Sci Rep. 2015;5:14148.
Zell JA, Lin BS, Ziogas A, Anton‐Culver H. Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis. J Carcinog. 2012;11:17.
Zell JA, McEligot AJ, Ziogas A, Holcombe RF, Anton‐Culver H. Differential effects of wine consumption on colorectal cancer outcomes based on family history of the disease. Nutr Cancer. 2007;59:36‐45.
Zell JA, Ziogas A, Bernstein L, et al. Meat consumption, nonsteroidal anti‐inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study. Cancer Prev Res (Phila). 2010;3:865‐875.
Zhou J, Ge X, Fan X, Wang J, Miao L, Hang D. Associations of vitamin D status with colorectal cancer risk and survival. Int J Cancer. 2021;149:606‐614.
Zhu Y, Zhao J, Vallis J, et al. Prediagnostic consumption of vitamin D, calcium and dairy products and colorectal cancer survival: results from the Newfoundland Colorectal Cancer Registry Cohort Study. Br J Nutr. 2022;128:290‐299.
Aarts MJ, Kamphuis CB, Louwman MJ, Coebergh JW, Mackenbach JP, van Lenthe FJ. Educational inequalities in cancer survival: a role for comorbidities and health behaviours? J Epidemiol Community Health. 2013;67:365‐373.
Annie FH, Uejio CK, Bhagat A, Kochar T, Embrey S, Tager A. Survival analysis of cancer patients of differing payer type in South West Virginia, between 2000 and 2013. Cureus. 2018;10:e3022.
Boyle T, Fritschi L, Platell C, Heyworth J. Lifestyle factors associated with survival after colorectal cancer diagnosis. Br J Cancer. 2013;109:814‐822.
Gannavarapu BS, Lau SKM, Carter K, et al. Prevalence and survival impact of pretreatment cancer‐associated weight loss: a tool for guiding early palliative care. J Oncol Pract. 2018;14:e238‐e250.
Minami Y, Kanemura S, Oikawa T, et al. Associations of Japanese food intake with survival of stomach and colorectal cancer: a prospective patient cohort study. Cancer Sci. 2020;111:2558‐2569.
Phipps AI, Baron J, Newcomb PA. Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival: the Seattle Colon Cancer Family Registry. Cancer. 2011;117:4948‐4957.
Phipps AI, Robinson JR, Campbell PT, et al. Prediagnostic alcohol consumption and colorectal cancer survival: the Colon Cancer Family Registry. Cancer. 2017;123:1035‐1043.
Park J, Kim JH, Lee HJ, et al. The effects of physical activity and body fat mass on colorectal polyp recurrence in patients with previous colorectal cancer. Cancer Prev Res (Phila). 2017;10:478‐484.
Jeon J, Sato K, Niedzwiecki D, et al. Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer: Findings from CALGB 89803/Alliance. Clin Colorectal Cancer. 2013;12:233‐238.
Cheng E, Ou FS, Ma C, et al. Diet‐ and lifestyle‐based prediction models to estimate cancer recurrence and death in patients with stage III colon cancer (CALGB 89803/Alliance). J Clin Oncol. 2022;40:740‐751.
van Zutphen M, van Duijnhoven FJB, Wesselink E, et al. Identification of lifestyle behaviors associated with recurrence and survival in colorectal cancer patients using random survival forests. Cancer. 2021;13:2442.
Morikawa T, Kuchiba A, Yamauchi M, et al. Association of CTNNB1 (beta‐catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. Jama. 2011;305:1685‐1694.
Cheng CC, Lai IL, Huang SH, et al. Association of preoperative physical activity with short‐ and long‐term outcomes in patients undergoing palliative resection for metastatic colorectal cancer: an inverse probability of treatment weighting analysis. Cancer. 2022;14:489.
You JF, Hsu YJ, Chern YJ, et al. Association of a preoperative leisure‐time physical activity with short‐ and long‐term outcomes of patients undergoing curative resection for stage I to III colorectal cancer: a propensity score matching analysis. Dis Colon Rectum. 2020;63:796‐806.
Piringer G, Vormittag L, Ohler L, et al. REGO‐ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer. Wien Klin Wochenschr. 2020;132:423‐430.
Lee M, Lee Y, Jang D, Shin A. Physical activity after colorectal cancer diagnosis and mortality in a Nationwide Retrospective Cohort Study. Cancer. 2021;13:4804.
van Zutphen M, Boshuizen HC, Kenkhuis MF, et al. Lifestyle after colorectal cancer diagnosis in relation to recurrence and all‐cause mortality. Am J Clin Nutr. 2021;113:1447‐1457.
Tarasenko YN, Linder DF, Miller EA. Muscle‐strengthening and aerobic activities and mortality among 3+ year cancer survivors in the U.S. Cancer Causes Control. 2018;29:475‐484.
Tamakoshi A, Nakamura K, Ukawa S, et al. Characteristics and prognosis of Japanese colorectal cancer patients: the BioBank Japan Project. J Epidemiol. 2017;27:S36‐S42.
Hanyuda A, Kim SA, Martinez‐Fernandez A, et al. Survival benefit of exercise differs by tumor IRS1 expression status in colorectal cancer. Ann Surg Oncol. 2016;23:908‐917.
Ratjen I, Schafmayer C, di Giuseppe R, et al. Postdiagnostic physical activity, sleep duration, and TV watching and all‐cause mortality among long‐term colorectal cancer survivors: a prospective cohort study. BMC Cancer. 2017;17:701.
Arem H, Pfeiffer RM, Engels EA, et al. Pre‐ and postdiagnosis physical activity, television viewing, and mortality among patients with colorectal cancer in the National Institutes of Health‐AARP Diet and Health Study. J Clin Oncol. 2015;33:180‐188.
Cao Y, Meyerhardt JA, Chan AT, Wu K, Fuchs CS, Giovannucci EL. Television watching and colorectal cancer survival in men. Cancer Causes Control. 2015;26:1467‐1476.
Campbell PT, Patel AV, Newton CC, Jacobs EJ, Gapstur SM. Associations of recreational physical activity and leisure time spent sitting with colorectal cancer survival. J Clin Oncol. 2013;31:876‐885.
Yamauchi M, Lochhead P, Imamura Y, et al. Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. Cancer Epidemiol Biomark Prev. 2013;22:1142‐1152.
Kuiper JG, Phipps AI, Neuhouser ML, et al. Recreational physical activity, body mass index, and survival in women with colorectal cancer. Cancer Causes Control. 2012;23:1939‐1948.
Baade PD, Meng X, Youl PH, Aitken JF, Dunn J, Chambers SK. The impact of body mass index and physical activity on mortality among patients with colorectal cancer in Queensland, Australia. Cancer Epidemiol Biomark Prev. 2011;20:1410‐1420.
Meyerhardt JA, Ogino S, Kirkner GJ, et al. Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin Cancer Res. 2009;15:5931‐5936.
Meyerhardt JA, Giovannucci EL, Ogino S, et al. Physical activity and male colorectal cancer survival. Arch Intern Med. 2009;169:2102‐2108.
Meyerhardt JA, Giovannucci EL, Holmes MD, et al. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol. 2006;24:3527‐3534.
Smit KC, Derksen JWG, Beets GLO, et al. Physical activity is associated with improved overall survival among patients with metastatic colorectal cancer. Cancer. 2022;14:1001.
Guercio BJ, Zhang S, Ou FS, et al. Associations of physical activity with survival and progression in metastatic colorectal cancer: results from Cancer and Leukemia Group B (Alliance)/SWOG 80405. J Clin Oncol. 2019;37:2620‐2631.
Van Blarigan EL, Fuchs CS, Niedzwiecki D, et al. Association of survival with adherence to the American Cancer Society nutrition and physical activity guidelines for cancer survivors after colon cancer diagnosis: the CALGB 89803/Alliance trial. JAMA Oncol. 2018;4:783‐790.
Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006;24:3535‐3541.
Phipps AI, Shi Q, Zemla TJ, et al. Physical activity and outcomes in patients with stage III colon cancer: a correlative analysis of phase III trial NCCTG N0147 (Alliance). Cancer Epidemiol Biomark Prev. 2018;27:696‐703.
Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000;32:S498‐S504.
Quadrilatero J, Hoffman‐Goetz L. Physical activity and colon cancer. A systematic review of potential mechanisms. J Sports Med Phys Fitness. 2003;43:121‐138.
Wang T, Zhang Y, Taaffe DR, et al. Protective effects of physical activity in colon cancer and underlying mechanisms: a review of epidemiological and biological evidence. Crit Rev Oncol Hematol. 2022;170:103578.
Sax AT, Jenkins DG, Devin JL, Hughes GI, Bolam KA, Skinner TL. The insulin‐like growth factor axis: a biological mechanism linking physical activity to colorectal cancer survival. Cancer Epidemiol. 2014;38:455‐459.
Friedenreich CM, Shaw E, Neilson HK, Brenner DR. Epidemiology and biology of physical activity and cancer recurrence. J Mol Med (Berl). 2017;95:1029‐1041.
Taylor CA, Cheng CP, Espinosa LA, Tang BT, Parker D, Herfkens RJ. In vivo quantification of blood flow and wall shear stress in the human abdominal aorta during lower limb exercise. Ann Biomed Eng. 2002;30:402‐408.
Regmi S, Fu A, Luo KQ. High shear stresses under exercise condition destroy circulating tumor cells in a microfluidic system. Sci Rep. 2017;7:39975.
Brown JC, Rhim AD, Manning SL, et al. Effects of exercise on circulating tumor cells among patients with resected stage I–III colon cancer. PLoS One. 2018;13:e0204875.
Liberman K, Forti LN, Beyer I, Bautmans I. The effects of exercise on muscle strength, body composition, physical functioning and the inflammatory profile of older adults: a systematic review. Curr Opin Clin Nutr Metab Care. 2017;20:30‐53.
Petersen AM, Pedersen BK. The anti‐inflammatory effect of exercise. J Appl Physiol (Bethesda, MD 1985). 2005;98:1154‐1162.
Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8:457‐465.
Shim YJ, Kim HJ, Oh SC, Lee SI, Choi SW. Exercise during adjuvant treatment for colorectal cancer: treatment completion, treatment‐related toxicities, body composition, and serum level of adipokines. Cancer Manag Res. 2019;11:5403‐5412.
Darkwah S, Park EJ, Myint PK, et al. Potential roles of muscle‐derived extracellular vesicles in remodeling cellular microenvironment: proposed implications of the exercise‐induced myokine, irisin. Front Cell Dev Biol. 2021;9:634853.
Zhang Y, Kim JS, Wang TZ, et al. Potential role of exercise induced extracellular vesicles in prostate cancer suppression. Front Oncol. 2021;11:746040.
Pedersen BK. Exercise‐induced myokines and their role in chronic diseases. Brain Behav Immun. 2011;25:811‐816.
McClellan JL, Steiner JL, Day SD, et al. Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesis. Int J Oncol. 2014;45:861‐868.
Barozzi C, Ravaioli M, D'Errico A, et al. Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. Cancer. 2002;94:647‐657.
Glass AR, Kikendall JW, Sobin LH, Bowen PE. Serum concentrations of insulin‐like growth factor 1 in colonic neoplasia. Acta Oncol (Stockh, Swed). 1994;33:70‐71.
Renehan AG, Painter JE, Atkin WS, Potten CS, Shalet SM, O'Dwyer ST. High‐risk colorectal adenomas and serum insulin‐like growth factors. Br J Surg. 2001;88:107‐113.
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High‐Risk Stage II or Stage III Colon Cancer (CHALLENGE). Accessed November 2023. https://clinicaltrials.gov/study/NCT00819208
Gorzelitz J, Peppard PE, Malecki K, Gennuso K, Nieto FJ, Cadmus‐Bertram L. Predictors of discordance in self‐report versus device‐measured physical activity measurement. Ann Epidemiol. 2018;28:427‐431.
Boyle T, Lynch BM, Courneya KS, Vallance JK. Agreement between accelerometer‐assessed and self‐reported physical activity and sedentary time in colon cancer survivors. Support Care Cancer. 2015;23:1121‐1126.
Courneya KS, Friedenreich CM. Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med (New York, NY). 1997;3:215‐226.
Cabilan CJ, Hines S. The short‐term impact of colorectal cancer treatment on physical activity, functional status and quality of life: a systematic review. JBI Database System Rev Implement Rep. 2017;15:517‐566.
Adamsen L, Andersen C, Lillelund C, Bloomquist K, Møller T. Rethinking exercise identity: a qualitative study of physically inactive cancer patients' transforming process while undergoing chemotherapy. BMJ Open. 2017;7:e016689.
Renman D, Strigård K, Palmqvist R, Näsvall P, Gunnarsson U, Edin‐Liljegren A. Attitudes to and experiences of physical activity after colon cancer diagnosis amongst physically active individuals—a qualitative study. Cancer Control. 2022;29:10732748221119352.
Mosher CE, Sloane R, Morey MC, et al. Associations between lifestyle factors and quality of life among older long‐term breast, prostate, and colorectal cancer survivors. Cancer. 2009;115:4001‐4009.
Mols F, Beijers AJ, Vreugdenhil G, Verhulst A, Schep G, Husson O. Chemotherapy‐induced peripheral neuropathy, physical activity and health‐related quality of life among colorectal cancer survivors from the PROFILES registry. J Cancer Surviv Res Pract. 2015;9:512‐522.
Husson O, Mols F, Ezendam NP, Schep G, van de Poll‐Franse LV. Health‐related quality of life is associated with physical activity levels among colorectal cancer survivors: a longitudinal, 3‐year study of the PROFILES registry. J Cancer Surviv Res Pract. 2015;9:472‐480.
Williams K, Beeken RJ, Wardle J. Health behaviour advice to cancer patients: the perspective of social network members. Br J Cancer. 2013;108:831‐835.
Beeken RJ, Williams K, Wardle J, Croker H. “What about diet?” A qualitative study of cancer survivors' views on diet and cancer and their sources of information. Eur J Cancer Care. 2016;25:774‐783.
Smith L, Croker H, Fisher A, Williams K, Wardle J, Beeken RJ. Cancer survivors' attitudes towards and knowledge of physical activity, sources of information, and barriers and facilitators of engagement: a qualitative study. Eur J Cancer Care. 2017;26:e12641.