Mutation of the ALS/FTD-associated RNA-binding protein FUS affects axonal development.

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
01 May 2024
Historique:
received: 14 11 2023
revised: 23 02 2024
accepted: 29 03 2024
medline: 2 5 2024
pubmed: 2 5 2024
entrez: 1 5 2024
Statut: aheadofprint

Résumé

Aberrant condensation and localisation of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organisation and branching in neurodevelopmental disorders. Here, we asked whether branching defects also occur in vivo in a model of FUS-associated disease. We use two reported

Identifiants

DOI: 10.1523/JNEUROSCI.2148-23.2024 PMID: 38692734
pubmed: 38692734
pii: JNEUROSCI.2148-23.2024
doi: 10.1523/JNEUROSCI.2148-23.2024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 the authors.

Auteurs

Francesca W van Tartwijk (FWV)

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.

Lucia C S Wunderlich (LCS)

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.

Ioanna Mela (I)

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.

Stanislaw Makarchuk (S)

UK Dementia Research Institute and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 OAH, UK.

Maximilian A H Jakobs (MAH)

Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

Seema Qamar (S)

Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.

Kristian Franze (K)

Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

Gabriele S Kaminski Schierle (GSK)

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.

Peter H St George-Hyslop (PHS)

Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.
Department of Medicine, University of Toronto and University Health Network and Tanz Centre for Research in Neurodegenerative Diseases University of Toronto, Toronto, ON M5T 0S8, Canada.
Taub Institute For Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Irvine Medical Center, 630 West 168 Street, New York, NY, USA 10032.

Julie Qiaojin Lin (JQ)

UK Dementia Research Institute and Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 OAH, UK.
UK Dementia Research Institute Centre and Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, SE5 9NU, UK.

Christine E Holt (CE)

Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

Clemens F Kaminski (CF)

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK cfk23@cam.ac.uk.

Classifications MeSH