Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
01 May 2024
01 May 2024
Historique:
received:
02
02
2023
accepted:
01
12
2023
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
1
5
2024
Statut:
aheadofprint
Résumé
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
Identifiants
pubmed: 38693320
doi: 10.1038/s42255-023-00959-9
pii: 10.1038/s42255-023-00959-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : U24DK112349
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : U24DK112341
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : U24DK112340
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : U24DK112341
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : U01AG055135
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : U01AG055133
Investigateurs
Jose Juan Almagro Armenteros
(JJA)
Mary Anne S Amper
(MAS)
Euan Ashley
(E)
Aneesh Kumar Asokan
(AK)
Julian Avila-Pacheco
(J)
Dam Bae
(D)
Marcas M Bamman
(MM)
Nasim Bararpour
(N)
Jerry Barnes
(J)
Thomas W Buford
(TW)
Charles F Burant
(CF)
Nicholas P Carbone
(NP)
Steven A Carr
(SA)
Toby L Chambers
(TL)
Clarisa Chavez
(C)
Roxanne Chiu
(R)
Clary B Clish
(CB)
Gary R Cutter
(GR)
Surendra Dasari
(S)
Courtney Dennis
(C)
Charles R Evans
(CR)
Facundo M Fernandez
(FM)
Nicole Gagne
(N)
Yongchao Ge
(Y)
Bret H Goodpaster
(BH)
Marina A Gritsenko
(MA)
Joshua R Hansen
(JR)
Krista M Hennig
(KM)
Kim M Huffman
(KM)
Chia-Jui Hung
(CJ)
Chelsea Hutchinson-Bunch
(C)
Olga Ilkayeva
(O)
Anna A Ivanova
(AA)
Pierre M Jean Beltran
(PMJ)
Christopher A Jin
(CA)
Maureen T Kachman
(MT)
Hasmik Keshishian
(H)
William E Kraus
(WE)
Ian Lanza
(I)
Bridget Lester
(B)
Jun Z Li
(JZ)
Ana K Lira
(AK)
Xueyun Liu
(X)
Kristal M Maner-Smith
(KM)
Sandy May
(S)
Matthew R Monroe
(MR)
Stephen Montgomery
(S)
Ronald J Moore
(RJ)
Samuel G Moore
(SG)
Daniel Nachun
(D)
K Sreekumaran Nair
(KS)
Venugopalan Nair
(V)
Archana Natarajan Raja
(AN)
Michael D Nestor
(MD)
German Nudelman
(G)
Vladislav A Petyuk
(VA)
Paul D Piehowski
(PD)
Hanna Pincas
(H)
Wei-Jun Qian
(WJ)
Alexander Raskind
(A)
Blake B Rasmussen
(BB)
Jessica L Rooney
(JL)
Scott Rushing
(S)
Mihir Samdarshi
(M)
Stuart C Sealfon
(SC)
Kevin S Smith
(KS)
Gregory R Smith
(GR)
Michael Snyder
(M)
Cynthia L Stowe
(CL)
Jennifer W Talton
(JW)
Christopher Teng
(C)
Anna Thalacker-Mercer
(A)
Russell Tracy
(R)
Todd A Trappe
(TA)
Mital Vasoya
(M)
Nikolai G Vetr
(NG)
Elena Volpi
(E)
Michael P Walkup
(MP)
Martin J Walsh
(MJ)
Matthew T Wheeler
(MT)
Si Wu
(S)
Elena Zaslavsky
(E)
Navid Zebarjadi
(N)
Tiantian Zhang
(T)
Bingqing Zhao
(B)
Jimmy Zhen
(J)
Informations de copyright
© 2024. Battelle Memorial Institute.
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