Melanotic neuroectodermal tumor of infancy: a case report.
Case report
Melanotic
Neuroectodermal
Tumor of infancy
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
02 May 2024
02 May 2024
Historique:
received:
26
08
2022
accepted:
27
03
2024
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
1
5
2024
Statut:
epublish
Résumé
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare clinically benign, pigmented, tumor of neural crest origin which commonly occurs in the maxilla. It is a rare tumor that may pose difficulty in differentiating from other malignant round cell tumors. A 5-month-old Ethiopian infant presented with a mass on his forehead. A wide excision of the lesion was done and subjected to histopathologic evaluation. The histologic and immunohistochemistry for synaptophysin studies confirmed that the infant was having MNTI. The patient was followed and there was no sign of recurrence at the 6th and 9th months of follow-up. MNTI should be considered as a differential diagnosis for tumors occurring in the head region in infants and prolonged follow-up may be needed to check for possible recurrence of the tumor.
Sections du résumé
BACKGROUND
BACKGROUND
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare clinically benign, pigmented, tumor of neural crest origin which commonly occurs in the maxilla. It is a rare tumor that may pose difficulty in differentiating from other malignant round cell tumors.
CASE PRESENTATION
METHODS
A 5-month-old Ethiopian infant presented with a mass on his forehead. A wide excision of the lesion was done and subjected to histopathologic evaluation. The histologic and immunohistochemistry for synaptophysin studies confirmed that the infant was having MNTI. The patient was followed and there was no sign of recurrence at the 6th and 9th months of follow-up.
CONCLUSION
CONCLUSIONS
MNTI should be considered as a differential diagnosis for tumors occurring in the head region in infants and prolonged follow-up may be needed to check for possible recurrence of the tumor.
Identifiants
pubmed: 38693549
doi: 10.1186/s13256-024-04550-y
pii: 10.1186/s13256-024-04550-y
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
230Informations de copyright
© 2024. The Author(s).
Références
Jain P, Saxena S, Aryya N. Melanotic neuroectodermal tumour of infancy: a rare maxillary alveolar tumour. Eur J Plast Surg. 2003;26(1):35–7.
doi: 10.1007/s00238-002-0415-3
Agarwal P, Agarwal V, Raina VK. Melanotic neuroectodermal tumour of infancy: Case report of an unusual tumor. Indian J Plastic Surg. 2003;36(2):123–5.
Selim H, Shaheen S, Barakat K, Selim A. Melanotic neuroectodermal tumor of infancy: review of literature and case report. J Pediatr Surg. 2008;43(6):e25–9.
doi: 10.1016/j.jpedsurg.2008.02.068
pubmed: 18558161
Sailukar M, Bhagwat R, Seth T. Melanocytic neuroectodermal tumor of infancy. J Indian Assoc Pediatr Surg. 2007;12(3):136.
doi: 10.4103/0971-9261.34952
Antunes ACM, Freitas RM, Oliveira PP, Rebouças RG. Melanotic neuroectodermal tumor of infancy: case report. Arq Neuropsiquiatr. 2005;63(3A):670–2.
doi: 10.1590/S0004-282X2005000400022
pubmed: 16172721
Nožicka Z, Špacek J. Melanotic neuroectodermal tumor of infancy with highly differentiated neural component: Light and Electron microscopy study. Acta Neuropathol (Berl). 1978;44:229–33.
doi: 10.1007/BF00691072
pubmed: 735759
Johnson RE, Scheithauer BW, Dahlin DC. Melanotic neuroectodermal tumor of infancy : a review of seven cases. Cancer. 1983;52:661–6.
doi: 10.1002/1097-0142(19830815)52:4<661::AID-CNCR2820520416>3.0.CO;2-X
pubmed: 6305482
George JC, Edwards MK, Jakacki RI, Kho-Duffin J. Melanotic neuroectodermal tumor of infancy. AJNR. 1995;16:1273–5.
pubmed: 7677023
pmcid: 8337818
Shanon L, Matthew K. Melanotic neuroectodermal tumor of infancy presenting in the subcutaneous soft tissue of the thigh. AM J Dermatol. 2010;32(3):282–6.
doi: 10.1097/DAD.0b013e3181b623a7
Jain P, Garg RK, Kapoor A. Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. Fetal Pediatr Pathol. 2010;29(5):344–52.
doi: 10.3109/15513815.2010.494702
pubmed: 20704481
Wei SHY, Cheung LK, Tideman H, Wu PC. Clinical management of a child with Melanotic neuroectodermal tumor of infancy. HKMJ. 1996;2(2):177–80.
Neven J, Hulsbergen-van der Kaa C, Groot-Loonen J, de Wilde PC, Merkx MA. Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):493–6
Nakanishi K, Hori H, Matsubara T, Matsuda K, Deguchi T, Komada Y. Recurrent melanotic neuroectodermal tumor in the orbit successfully treated with resection followed by pediculated periosteal flaps. Pediatr Blood Cancer. 2008;51(3):430–2.
doi: 10.1002/pbc.21607
pubmed: 18493990
Ellison DA, Adada B, Qualman SJ, Parham DM. Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation. Pediatr Dev Pathol. 2007;10(2):157–60.
doi: 10.2350/06-07-0138.1
pubmed: 17378694
Lambropoulos V, Neofytou A, Sfougaris D, Mouravas V, Petropoulos A. Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases. Acta Neurochir (Wien). 2010;152(5):869–75.
doi: 10.1007/s00701-009-0472-5
pubmed: 19669690