Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of

Campylobacter jejuni microbiome poultry production system small molecule inhibitor twin arginine translocase

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2024
Historique:
received: 22 11 2023
accepted: 08 03 2024
medline: 2 5 2024
pubmed: 2 5 2024
entrez: 2 5 2024
Statut: epublish

Résumé

Control of Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors targeting the Tat system would allow the development of safe and effective control methods to mitigate Furthermore, we evaluated 177 SM hits (2.5 μg/mL and above) that increased the susceptibility to CuSO Thus, we have identified novel SM inhibitors of the Tat pathway, which represent a potential strategy to control

Identifiants

pubmed: 38694802
doi: 10.3389/fmicb.2024.1342573
pmc: PMC11061419
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1342573

Informations de copyright

Copyright © 2024 Deblais, Drozd, Kumar, Antwi, Fuchs, Khupse, Helmy and Rajashekara.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Loïc Deblais (L)

Department of Animal Sciences, The Ohio State University, OARDC, Wooster, OH, United States.

Mary Drozd (M)

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States.

Anand Kumar (A)

Los Alamos National Laboratory, Bioscience Division, Group B-10: Biosecurity and Public Health, Los Alamos, NM, United States.

Janet Antwi (J)

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States.

James Fuchs (J)

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States.

Rahul Khupse (R)

College of Pharmacy, University of Findlay, OH, United States.

Yosra A Helmy (YA)

Department of Animal Sciences, The Ohio State University, OARDC, Wooster, OH, United States.

Gireesh Rajashekara (G)

Department of Animal Sciences, The Ohio State University, OARDC, Wooster, OH, United States.

Classifications MeSH