Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of
Campylobacter jejuni
microbiome
poultry production system
small molecule inhibitor
twin arginine translocase
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2024
2024
Historique:
received:
22
11
2023
accepted:
08
03
2024
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
2
5
2024
Statut:
epublish
Résumé
Control of Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors targeting the Tat system would allow the development of safe and effective control methods to mitigate Furthermore, we evaluated 177 SM hits (2.5 μg/mL and above) that increased the susceptibility to CuSO Thus, we have identified novel SM inhibitors of the Tat pathway, which represent a potential strategy to control
Identifiants
pubmed: 38694802
doi: 10.3389/fmicb.2024.1342573
pmc: PMC11061419
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1342573Informations de copyright
Copyright © 2024 Deblais, Drozd, Kumar, Antwi, Fuchs, Khupse, Helmy and Rajashekara.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.