Hippocampal region metabolites and cognitive impairment in patients with general paresis: based on
Treponema pallidum
general paresis
general paresis of insane
hippocampus
magnetic resonance spectroscopy
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2024
2024
Historique:
received:
05
02
2024
accepted:
26
03
2024
medline:
2
5
2024
pubmed:
2
5
2024
entrez:
2
5
2024
Statut:
epublish
Résumé
This study utilizes Hydrogen proton magnetic resonance spectroscopy ( A total of 80 GP patients and 57 normal controls (NCs) were enrolled. Metabolite ratios in the bilateral hippocampus were measured using MMSE scores progressively decreased in the normal, mild cognitive impairment, and moderate-severe dementia groups ( There are distinctive metabolic characteristics in the hippocampus of GP patients. GP patients exhibited lower NAA/Cr and NAA/Cho ratios in the bilateral hippocampus, indicating neuron loss in these areas, which may become more pronounced as the disease progresses.
Sections du résumé
Background
UNASSIGNED
This study utilizes Hydrogen proton magnetic resonance spectroscopy (
Methods
UNASSIGNED
A total of 80 GP patients and 57 normal controls (NCs) were enrolled. Metabolite ratios in the bilateral hippocampus were measured using
Results
UNASSIGNED
MMSE scores progressively decreased in the normal, mild cognitive impairment, and moderate-severe dementia groups (
Conclusion
UNASSIGNED
There are distinctive metabolic characteristics in the hippocampus of GP patients. GP patients exhibited lower NAA/Cr and NAA/Cho ratios in the bilateral hippocampus, indicating neuron loss in these areas, which may become more pronounced as the disease progresses.
Identifiants
pubmed: 38694926
doi: 10.3389/fphar.2024.1382381
pii: 1382381
pmc: PMC11061413
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1382381Informations de copyright
Copyright © 2024 Che, Miao, Shi, Li and Ning.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.