Real-life effectiveness of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients previously treated with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir.


Journal

Alimentary pharmacology & therapeutics
ISSN: 1365-2036
Titre abrégé: Aliment Pharmacol Ther
Pays: England
ID NLM: 8707234

Informations de publication

Date de publication:
02 May 2024
Historique:
revised: 04 03 2024
received: 09 02 2024
accepted: 14 04 2024
medline: 2 5 2024
pubmed: 2 5 2024
entrez: 2 5 2024
Statut: aheadofprint

Résumé

Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct-acting antivirals (DAAs). Data are limited on the effectiveness of this treatment after the current first-line therapies. Our aim was to analyse the effectiveness and safety of SOF/VEL/VOX among patients failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB). Retrospective multicentre study (26 Spanish hospitals), including chronic hepatitis C patients unsuccessfully treated with SOF/VEL or GLE/PIB, and retreated with SOF/VEL/VOX ± ribavirin for 12 weeks between December 2017 and December 2022. In total, 142 patients included: 100 (70.4%) had failed SOF/VEL and 42 (29.6%) GLE/PIB. Patients were mainly men (84.5%), White (93.9%), with hepatitis C virus genotype (GT) 3 (49.6%) and 47.2% had liver cirrhosis. Sustained virological response (SVR) was evaluated in 132 patients who completed SOF/VEL/VOX and were followed 12 weeks after end of treatment; 117 (88.6%) achieved SVR. There were no significant differences in SVR rates according to initial DAA treatment (SOF/VEL 87.9% vs. GLE/PIB 90.2%, p = 0.8), cirrhosis (no cirrhosis 90% vs. cirrhosis 87.1%, p = 0.6) or GT3 infection (non-GT3 91.9% vs. GT3 85.5%, p = 0.3). However, when considering the concurrent presence of SOF/VEL treatment, cirrhosis and GT3 infection, SVR rates dropped to 82.8%. Ribavirin was added in 8 (6%) patients, all achieved SVR. SOF/VEL/VOX is an effective rescue therapy for failures to SOF/VEL or GLE/PIB, with an SVR of 88.6%. Factors previously linked to lower SVR rates, such as GT3 infection, cirrhosis and first-line therapy with SOF/VEL were not associated with lower SVRs.

Sections du résumé

BACKGROUND BACKGROUND
Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct-acting antivirals (DAAs). Data are limited on the effectiveness of this treatment after the current first-line therapies. Our aim was to analyse the effectiveness and safety of SOF/VEL/VOX among patients failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB).
METHODS METHODS
Retrospective multicentre study (26 Spanish hospitals), including chronic hepatitis C patients unsuccessfully treated with SOF/VEL or GLE/PIB, and retreated with SOF/VEL/VOX ± ribavirin for 12 weeks between December 2017 and December 2022.
RESULTS RESULTS
In total, 142 patients included: 100 (70.4%) had failed SOF/VEL and 42 (29.6%) GLE/PIB. Patients were mainly men (84.5%), White (93.9%), with hepatitis C virus genotype (GT) 3 (49.6%) and 47.2% had liver cirrhosis. Sustained virological response (SVR) was evaluated in 132 patients who completed SOF/VEL/VOX and were followed 12 weeks after end of treatment; 117 (88.6%) achieved SVR. There were no significant differences in SVR rates according to initial DAA treatment (SOF/VEL 87.9% vs. GLE/PIB 90.2%, p = 0.8), cirrhosis (no cirrhosis 90% vs. cirrhosis 87.1%, p = 0.6) or GT3 infection (non-GT3 91.9% vs. GT3 85.5%, p = 0.3). However, when considering the concurrent presence of SOF/VEL treatment, cirrhosis and GT3 infection, SVR rates dropped to 82.8%. Ribavirin was added in 8 (6%) patients, all achieved SVR.
CONCLUSION CONCLUSIONS
SOF/VEL/VOX is an effective rescue therapy for failures to SOF/VEL or GLE/PIB, with an SVR of 88.6%. Factors previously linked to lower SVR rates, such as GT3 infection, cirrhosis and first-line therapy with SOF/VEL were not associated with lower SVRs.

Identifiants

pubmed: 38695095
doi: 10.1111/apt.18020
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.

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Auteurs

Juan Carlos Ruiz-Cobo (JC)

Liver Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Jordi Llaneras (J)

Liver Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Xavier Forns (X)

Liver Unit, Hospital Clínic, Barcelona, Spain.
Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
University of Barcelona (UB), Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

Adolfo Gallego Moya (A)

Servicio de Patología Digestiva, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Isabel Conde Amiel (I)

Hepatology and Liver Transplantation Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

Ana Arencibia (A)

Gastroenterology Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Moises Diago (M)

Hospital General Universitario Valencia, Valencia, Spain.
Medicine Department, Universidad de Valencia, Valencia, Spain.

Javier García-Samaniego (J)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Liver Unit, Hospital Universitario La Paz, Madrid, Spain.
Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.
Universidad Autónoma de Madrid, Madrid, Spain.

Jose Castellote (J)

University of Barcelona (UB), Barcelona, Spain.
Hepatology Unit, Gastroenterology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Universitat de Barcelona, Barcelona, Spain.

Susana Llerena (S)

Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain.

Elisa Rodríguez-Seguel (E)

Liver Diseases, Instituto de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Hospital Universitario Virgen del Rocío, Seville, Spain.
Digestive Diseases Research Unit, Virgen Del Rocío University Hospital, Seville, Spain.
Cell Biology Department, Faculty of Biology, University of Seville, Seville, Spain.

Beatriz Mateos (B)

Gastroenterology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
University of Alcala, Madrid, Spain.

Manuel Rodríguez (M)

Liver Unit, Gastroenterology and Hepatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain.
University of Oviedo, Oviedo, Spain.

Jose Miguel Rosales Zabal (JM)

Gastroenterology Department, Hospital Universitario Costa del Sol, Marbella, Spain.

Inmaculada Fernández (I)

Gastroenterology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.

Jose Luis Calleja (JL)

Universidad Autónoma de Madrid, Madrid, Spain.
Servicio de Gastroenterología y Hepatología, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Instituto de Investigación Sanitaria Puerta de Hierro (IDIPHIM), Madrid, Spain.

Rosa María Morillas (RM)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Hepatology Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.
Department of Medicine, Barcelona Autonomous University (UAB), Barcelona, Spain.

Silvia Montoliu (S)

Gastroenterology Department Hospital, Universitari Joan XXIII, Tarragona, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.

Raul J Andrade (RJ)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Hospital Universitario Virgen de la Victoria, Málaga, Spain.
University Hospital-IBIMA Platform BIONAND, Málaga, Spain.
University of Malaga, Málaga, Spain.

Ester Badia Aranda (E)

Gastroenterology Department, Hospital Universitario de Burgos, Burgos, Spain.

Manuel Hernández-Guerra (M)

Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.

Carlota Jimeno Maté (CJ)

Gastroenterology Department, Hospital Universitario Virgen de Valme, Sevilla, Spain.

Jesús M González-Santiago (JM)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Gastroenterology and Hepatology Department, University Hospital of Salamanca, Salamanca, Spain.
Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.

Beatriz de Cuenca (B)

Hospital Universitario de Getafe, Getafe, Spain.

Vanesa Bernal-Monterde (V)

Servicio de Aparato Digestivo, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Instituto de Investigación Sanitaria de Aragón (IISA), Zaragoza, Spain.

Manuel Delgado (M)

Hospital Universitario La Coruña, La Coruña, Spain.

Juan Turnes (J)

Department of Gastroenterology and Hepatology, Complejo Hospitalario Universitario Pontevedra & IIS Galicia Sur, Pontevedra, Spain.

Sabela Lens (S)

Liver Unit, Hospital Clínic, Barcelona, Spain.
Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
University of Barcelona (UB), Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

María Buti (M)

Liver Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

Classifications MeSH