Environmental pesticide exposure and Alzheimer's disease in southern Spain: A cross-sectional study.

Alzheimer disease Cross-sectional study Environmental chemicals Pesticides

Journal

Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385

Informations de publication

Date de publication:
27 Apr 2024
Historique:
received: 19 10 2023
revised: 24 04 2024
accepted: 26 04 2024
medline: 3 5 2024
pubmed: 3 5 2024
entrez: 2 5 2024
Statut: aheadofprint

Résumé

The intensive cultivation under plastic in southern Spain has made the agricultural model highly productive. Although strict regulations on pesticide usage exist, exposure to pesticides in the environment has been associated with an increased appearance of neurodegenerative diseases including Alzheimer's disease (AD). A cross-sectional study was performed to examine the prevalence and risk of AD related to pesticide exposure in Andalusia (Spain). We utilized the Odds Ratio statistical test to compare the prevalence rate of AD in the exposed and unexposed areas. 40,044 cases were collected from computerized hospital records between 2000 and 2021. Districts with higher pesticide use showed significantly higher prevalence rates and increased risk of developing AD, compared to those with lower pesticide use. These findings provide further evidence supporting an increased risk of AD following environmental exposure to pesticides at the level of the general population.

Identifiants

DOI: 10.1016/j.psychres.2024.115932 PMID: 38696970
pubmed: 38696970
pii: S0165-1781(24)00217-8
doi: 10.1016/j.psychres.2024.115932
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115932

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Cristofer Ruiz-González (C)

Torrecárdenas University Hospital, Calle Hermandad de Donantes de Sangre, s/n 04009, Almería, Spain; Research Group CTS-1114 Health Sciences, University of Almeria, Almeria, Spain.

Pablo Román (P)

Research Group CTS-1114 Health Sciences, University of Almeria, Almeria, Spain; Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento s/n, La Cañada 04120, Spain.

Lola Rueda-Ruzafa (L)

Research Group CTS-1114 Health Sciences, University of Almeria, Almeria, Spain; Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain. Electronic address: lrr606@ual.es.

Diana Cardona (D)

Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento s/n, La Cañada 04120, Spain.

Mar Requena (M)

Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento s/n, La Cañada 04120, Spain.

Raquel Alarcón (R)

Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento s/n, La Cañada 04120, Spain.

Classifications MeSH