Light-Responsive Pt(IV) Prodrugs with Controlled Photoactivation and Low Dark Toxicity.

BODIPY PET cisplatin photoactivation prodrug

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
02 May 2024
Historique:
medline: 3 5 2024
pubmed: 3 5 2024
entrez: 2 5 2024
Statut: aheadofprint

Résumé

Light-induced release of cisplatin from Pt(IV) prodrugs represents a promising approach for precise control over the antiproliferative activity of Pt-based chemotherapeutic drugs. This method has the potential to overcome crucial drawbacks of conventional cisplatin therapy, such as high general toxicity toward healthy organs and tissues. Herein, we report two Pt(IV) prodrugs with BODIPY-based photoactive ligands

Identifiants

DOI: 10.1021/acsabm.4c00345 PMID: 38697834
pubmed: 38697834
doi: 10.1021/acsabm.4c00345
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Daniil Spector (D)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.

Anna Bubley (A)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Anastasia Zharova (A)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Vladislav Bykusov (V)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Dmitry Skvortsov (D)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
ORCID: 0000-0001-8336-8596

Daria Ipatova (D)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Alexander Erofeev (A)

National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.

Petr Gorelkin (P)

National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.

Alexander Vaneev (A)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow 119049, Russia.
ORCID: 0000-0001-8201-8498

Dmitrii Mazur (D)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
ORCID: 0000-0002-9780-1490

Vita Nikitina (V)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Mikhail Melnikov (M)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Vladimir Pergushov (V)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.

Dmitry Bunin (D)

Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr., 31, bldg. 4, Moscow 119071, Russia.

Vladimir Kuzmin (V)

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.

Alexey Kostyukov (A)

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.

Anton Egorov (A)

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.

Elena Beloglazkina (E)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
ORCID: 0000-0001-6796-8241

Roman Akasov (R)

I.M. Sechenov First Moscow State Medical University, Trubetskaya 8-2, Moscow 119991, Russia.
Moscow Pedagogical State University, Malaya Pirogovskaya str. 1, Moscow 119435, Russia.
ORCID: 0000-0001-6486-8114

Olga Krasnovskaya (O)

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia.
ORCID: 0000-0002-4948-2747

Classifications MeSH