Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk.

Lung function in early adulthood is associated with subsequent adverse health outcomes. To ascertain whether stable and reproducible lung function trajectories can be derived in different populations and investigate their association with objective measures of cardiovascular structure and function. Using latent profile modelling, we studied three population-based birth cohorts with repeat spirometry data from childhood into early adulthood to identify trajectories of forced expiratory volume in 1 s (FEV We identified four FEV Childhood lung function trajectories may serve as predictors in the development of not only future lung disease, but also the cardiovascular disease and multimorbidity in adulthood.

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: RG, SH, MD, AU, OM, SF, LL, AS, CP, CSM and GR declare no conflicts of interest. AS has received research grants. JWD has received research and charity grants and declares pharmaceutical support for lectures and attending conferences/meetings. AH has received support from Research Institutions and declares an unpaid fiduciary role. JWH has received research grant and support for travel to congress. AC has received research grants, consulting fees, honoraria for lectures and declares unpaid fiduciary role.