Globally occurring pelagiphage infections create ribosome-deprived cells.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 May 2024
02 May 2024
Historique:
received:
09
02
2024
accepted:
22
04
2024
medline:
3
5
2024
pubmed:
3
5
2024
entrez:
2
5
2024
Statut:
epublish
Résumé
Phages play an essential role in controlling bacterial populations. Those infecting Pelagibacterales (SAR11), the dominant bacteria in surface oceans, have been studied in silico and by cultivation attempts. However, little is known about the quantity of phage-infected cells in the environment. Using fluorescence in situ hybridization techniques, we here show pelagiphage-infected SAR11 cells across multiple global ecosystems and present evidence for tight community control of pelagiphages on the SAR11 hosts in a case study. Up to 19% of SAR11 cells were phage-infected during a phytoplankton bloom, coinciding with a ~90% reduction in SAR11 cell abundance within 5 days. Frequently, a fraction of the infected SAR11 cells were devoid of detectable ribosomes, which appear to be a yet undescribed possible stage during pelagiphage infection. We dubbed such cells zombies and propose, among other possible explanations, a mechanism in which ribosomal RNA is used as a resource for the synthesis of new phage genomes. On a global scale, we detected phage-infected SAR11 and zombie cells in the Atlantic, Pacific, and Southern Oceans. Our findings illuminate the important impact of pelagiphages on SAR11 populations and unveil the presence of ribosome-deprived zombie cells as part of the infection cycle.
Identifiants
pubmed: 38698041
doi: 10.1038/s41467-024-48172-w
pii: 10.1038/s41467-024-48172-w
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3715Subventions
Organisme : Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (Alfred-Wegener- Institute, Helmholtz Centre for Polar and Marine Research)
ID : AWI_PS133/1_06
Organisme : Bundesministerium für Bildung, Wissenschaft und Kultur (Federal Ministry of Education, Science and Culture)
ID : 03G0245A
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 42076105
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : FOR 2406
Informations de copyright
© 2024. The Author(s).
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