Prematurity and congenital malformations differ according to the type of pregestational diabetes.
Humans
Female
Pregnancy
Pregnancy in Diabetics
/ epidemiology
Diabetes Mellitus, Type 1
/ complications
Diabetes Mellitus, Type 2
/ complications
Adult
Prospective Studies
Infant, Newborn
Congenital Abnormalities
/ epidemiology
Premature Birth
/ epidemiology
Hypoglycemia
/ epidemiology
Birth Weight
Body Mass Index
Glycated Hemoglobin
/ analysis
Pregnancy Outcome
/ epidemiology
Diabetes
High-risk pregnancy
Maternal-fetal medicine
Obesity
Pregnancy
Preterm delivery
Journal
BMC pregnancy and childbirth
ISSN: 1471-2393
Titre abrégé: BMC Pregnancy Childbirth
Pays: England
ID NLM: 100967799
Informations de publication
Date de publication:
02 May 2024
02 May 2024
Historique:
received:
11
01
2024
accepted:
30
03
2024
medline:
3
5
2024
pubmed:
3
5
2024
entrez:
2
5
2024
Statut:
epublish
Résumé
Diabetes mellitus (DM) is the most common metabolic disorder in pregnancy. Women with Type 2 DM seems to have no better perinatal outcomes than those with Type 1 DM. Single-center prospective cohort observational study. Pregnant women with diabetes (141 with Type 1 DM and 124 with Type 2 DM) that were followed in the university hospital between 2009 and 2021 were included in this study. Clinical data and obstetric and perinatal outcomes were collected. As expected, women with Type 1 DM were younger and had a longer duration of diabetes than women with Type 2 DM. Obesity and chronic hypertension were higher in the group of women with Type 2 DM and their value of HbA1c in the second and third trimesters were lower than in Type 1 DM. No differences in prematurity were found, but more extreme prematurity was observed in Type 2 DM, as well as a higher rate of congenital malformations. The frequency of hypoglycemia and the weight of the newborn was higher in Type 1 DM. The maternal independent factors related to the weight of the newborn were: the glycemic control at the third trimester, the weight gain during pregnancy, and pregestational BMI. Newborns born to mothers with Type 1 DM were larger and had a higher frequency of hypoglycemia, while congenital malformations and precocious preterm was more associated to Type 2 DM. Metabolic control, weight gain and pregestational weight were important determinants of both obstetric and neonatal complications.
Sections du résumé
BACKGROUND
BACKGROUND
Diabetes mellitus (DM) is the most common metabolic disorder in pregnancy. Women with Type 2 DM seems to have no better perinatal outcomes than those with Type 1 DM.
METHODS
METHODS
Single-center prospective cohort observational study. Pregnant women with diabetes (141 with Type 1 DM and 124 with Type 2 DM) that were followed in the university hospital between 2009 and 2021 were included in this study. Clinical data and obstetric and perinatal outcomes were collected.
RESULTS
RESULTS
As expected, women with Type 1 DM were younger and had a longer duration of diabetes than women with Type 2 DM. Obesity and chronic hypertension were higher in the group of women with Type 2 DM and their value of HbA1c in the second and third trimesters were lower than in Type 1 DM. No differences in prematurity were found, but more extreme prematurity was observed in Type 2 DM, as well as a higher rate of congenital malformations. The frequency of hypoglycemia and the weight of the newborn was higher in Type 1 DM. The maternal independent factors related to the weight of the newborn were: the glycemic control at the third trimester, the weight gain during pregnancy, and pregestational BMI.
CONCLUSIONS
CONCLUSIONS
Newborns born to mothers with Type 1 DM were larger and had a higher frequency of hypoglycemia, while congenital malformations and precocious preterm was more associated to Type 2 DM. Metabolic control, weight gain and pregestational weight were important determinants of both obstetric and neonatal complications.
Identifiants
pubmed: 38698309
doi: 10.1186/s12884-024-06470-7
pii: 10.1186/s12884-024-06470-7
doi:
Substances chimiques
Glycated Hemoglobin
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
335Subventions
Organisme : Instituto de Salud Carlos III
ID : PI21/1479
Informations de copyright
© 2024. The Author(s).
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