Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses.

RAFT polymerization Zika virus antivirals heparan sulfate mimetics mosquito-borne viruses poly(styrenesulfonate)

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
03 May 2024
Historique:
medline: 3 5 2024
pubmed: 3 5 2024
entrez: 3 5 2024
Statut: aheadofprint

Résumé

Mosquito-borne viruses are a major worldwide health problem associated with high morbidity and mortality rates and significant impacts on national healthcare budgets. The development of antiviral drugs for both the treatment and prophylaxis of these diseases is thus of considerable importance. To address the need for therapeutics with antiviral activity, a library of heparan sulfate mimetic polymers was screened against dengue virus (DENV), Yellow fever virus (YFV), Zika virus (ZIKV), and Ross River virus (RRV). The polymers were prepared by RAFT polymerization of various acidic monomers with a target MW of 20 kDa (average

Identifiants

DOI: 10.1021/acsabm.3c01223 PMID: 38699864
pubmed: 38699864
doi: 10.1021/acsabm.3c01223
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Abdullah Al Nahain (AA)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.

Jinlin Li (J)

Department of Medical Biochemistry and Microbiology, The Biomedical Center, University of Uppsala, 75123 Uppsala, Sweden.

Naphak Modhiran (N)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.

Daniel Watterson (D)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.

Jin-Ping Li (JP)

Department of Medical Biochemistry and Microbiology, The Biomedical Center, University of Uppsala, 75123 Uppsala, Sweden.

Vera Ignjatovic (V)

Haematology Research, Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-5548-5813

Paul Monagle (P)

Haematology Research, Murdoch Children's Research Institute, Parkville, Victoria 3052, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, Victoria 3052, Australia.
Department of Clinical Haematology, Royal Children's Hospital, Parkville, Victoria 3052, Australia.

John Tsanaktsidis (J)

CSIRO Manufacturing, Research Way, Clayton, Victoria 3168, Australia.

George Vamvounis (G)

College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia.
ORCID: 0000-0001-5906-4285

Vito Ferro (V)

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.
ORCID: 0000-0003-3306-2550

Classifications MeSH