Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex.

Animals Motor Cortex / physiology Cholecystokinin / metabolism Neuronal Plasticity / physiology Mice Motor Skills / physiology Learning / physiology Mice, Knockout Male
cholecystokinin entorhinal cortex motor cortex motor skill learning mouse neuroscience single pellet reaching task

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
03 May 2024
Historique:
received: 02 10 2022
accepted: 01 04 2024
medline: 3 5 2024
pubmed: 3 5 2024
entrez: 3 5 2024
Statut: epublish

Résumé

Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout of

Identifiants

DOI: 10.7554/eLife.83897 PMID: 38700136
pubmed: 38700136
doi: 10.7554/eLife.83897
pii: 83897
doi:
pii:

Substances chimiques

Cholecystokinin 9011-97-6

Banques de données

Dryad
['10.5061/dryad.9ghx3ffms']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hong Kong Research Grants Council
ID : GRF11103220M
Organisme : Hong Kong Research Grants Council
ID : GRF11101521M
Organisme : Hong Kong Research Grants Council, Collaborative Research Fund
ID : C1043-21GF
Organisme : Innovation and Technology Fund
ID : MRP/053/18X
Organisme : Innovation and Technology Fund
ID : GHP_075_19GD
Organisme : Health and Medical Research Fund
ID : HMRF09203656
Organisme : National Natural Science Foundation of China
ID : NSFC31671102

Informations de copyright

© 2024, Li et al.

Déclaration de conflit d'intérêts

HL, JF, MC, MX, XC, WL, LW, KW, JH No competing interests declared

Auteurs

Hao Li (H)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China.
ORCID: 0000-0001-5933-1443

Jingyu Feng (J)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

Mengying Chen (M)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

Min Xin (M)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China.

Xi Chen (X)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
ORCID: 0000-0002-2144-6584

Wenhao Liu (W)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

Liping Wang (L)

The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Kuan Hong Wang (KH)

Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, United States.
ORCID: 0000-0002-2249-5417

Jufang He (J)

Departments of Neuroscience and Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China.
ORCID: 0000-0002-4288-5957

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Cholécystokinine › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Phénomènes psychologiques › Aptitudes motrices › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Apprentissage › Cholecystokinin facilitates motor skill...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cholecystokinin facilitates motor skill...