Substance specific EEG patterns in mice undergoing slow anesthesia induction.
Animals
Mice
Ketamine
/ pharmacology
Sevoflurane
/ pharmacology
Dexmedetomidine
/ pharmacology
Electroencephalography
/ drug effects
Propofol
/ pharmacology
Male
Anesthetics, Inhalation
/ pharmacology
Reflex, Righting
/ drug effects
Mice, Inbred C57BL
Hypnotics and Sedatives
/ pharmacology
Anesthetics, Intravenous
/ pharmacology
Anesthesia
/ methods
Dexmedetomidine
EEG
Ketamine
Murine model
Propofol
Sevoflurane
Journal
BMC anesthesiology
ISSN: 1471-2253
Titre abrégé: BMC Anesthesiol
Pays: England
ID NLM: 100968535
Informations de publication
Date de publication:
03 May 2024
03 May 2024
Historique:
received:
06
03
2024
accepted:
26
04
2024
medline:
4
5
2024
pubmed:
4
5
2024
entrez:
3
5
2024
Statut:
epublish
Résumé
The exact mechanisms and the neural circuits involved in anesthesia induced unconsciousness are still not fully understood. To elucidate them valid animal models are necessary. Since the most commonly used species in neuroscience are mice, we established a murine model for commonly used anesthetics/sedatives and evaluated the epidural electroencephalographic (EEG) patterns during slow anesthesia induction and emergence. Forty-four mice underwent surgery in which we inserted a central venous catheter and implanted nine intracranial electrodes above the prefrontal, motor, sensory, and visual cortex. After at least one week of recovery, mice were anesthetized either by inhalational sevoflurane or intravenous propofol, ketamine, or dexmedetomidine. We evaluated the loss and return of righting reflex (LORR/RORR) and recorded the electrocorticogram. For spectral analysis we focused on the prefrontal and visual cortex. In addition to analyzing the power spectral density at specific time points we evaluated the changes in the spectral power distribution longitudinally. The median time to LORR after start anesthesia ranged from 1080 [1st quartile: 960; 3rd quartile: 1080]s under sevoflurane anesthesia to 1541 [1455; 1890]s with ketamine. Around LORR sevoflurane as well as propofol induced a decrease in the theta/alpha band and an increase in the beta/gamma band. Dexmedetomidine infusion resulted in a shift towards lower frequencies with an increase in the delta range. Ketamine induced stronger activity in the higher frequencies. Our results showed substance-specific changes in EEG patterns during slow anesthesia induction. These patterns were partially identical to previous observations in humans, but also included significant differences, especially in the low frequencies. Our study emphasizes strengths and limitations of murine models in neuroscience and provides an important basis for future studies investigating complex neurophysiological mechanisms.
Identifiants
pubmed: 38702608
doi: 10.1186/s12871-024-02552-3
pii: 10.1186/s12871-024-02552-3
doi:
Substances chimiques
Ketamine
690G0D6V8H
Sevoflurane
38LVP0K73A
Dexmedetomidine
67VB76HONO
Propofol
YI7VU623SF
Anesthetics, Inhalation
0
Hypnotics and Sedatives
0
Anesthetics, Intravenous
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
167Informations de copyright
© 2024. The Author(s).
Références
Weiser TG, Haynes AB, Molina G, Lipsitz SR, Esquivel MM, Uribe-Leitz T, Fu R, Azad T, Chao TE, Berry WR, et al. Size and distribution of the global volume of surgery in 2012. Bull World Health Organ. 2016;94(3):201–F209.
pubmed: 26966331
pmcid: 4773932
doi: 10.2471/BLT.15.159293
Hemmings HC Jr., Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA. Towards a Comprehensive understanding of anesthetic mechanisms of action: a decade of Discovery. Trends Pharmacol Sci. 2019;40(7):464–81.
pubmed: 31147199
pmcid: 6830308
doi: 10.1016/j.tips.2019.05.001
Snow JD. On the inhalation of the vapour of ether in surgical operations. London: John Churchill; 1847.
doi: 10.1016/S0140-6736(00)59240-X
Moody OA, Zhang ER, Vincent KF, Kato R, Melonakos ED, Nehs CJ, Solt K. The neural circuits underlying General Anesthesia and Sleep. Anesth Analg. 2021;132(5):1254–64.
pubmed: 33857967
pmcid: 8054915
doi: 10.1213/ANE.0000000000005361
The Rise of the Mouse, Biomedicine’s Model Mammal. Science 2000, 288(5464):248.
Berger H. Über das Elektrenkephalogramm des Menschen. Arch Psychiatr Nervenkrankh. 1929;87(1):527–70.
doi: 10.1007/BF01797193
Brazier MAB, Finesinger JE, ACTION OF BARBITURATES ON THE CEREBRAL CORTEX. ELECTROENCEPHALOGRAPHIC STUDIES. Archives Neurol Psychiatry. 1945;53(1):51–8.
doi: 10.1001/archneurpsyc.1945.02300010061005
Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N Engl J Med. 2010;363(27):2638–50.
pubmed: 21190458
pmcid: 3162622
doi: 10.1056/NEJMra0808281
Fahimi Hnazaee M, Wittevrongel B, Khachatryan E, Libert A, Carrette E, Dauwe I, Meurs A, Boon P, Van Roost D, Van Hulle MM. Localization of deep brain activity with scalp and subdural EEG. NeuroImage 2020, 223:117344.
Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014;121(5):990–8.
pubmed: 25233374
doi: 10.1097/ALN.0000000000000436
Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016;127(6):2414–22.
pubmed: 27178861
pmcid: 4871620
doi: 10.1016/j.clinph.2016.03.005
Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal dynamics of Dexmedetomidine-Induced Electroencephalogram oscillations. PLoS ONE. 2016;11(10):e0163431.
pubmed: 27711165
pmcid: 5053525
doi: 10.1371/journal.pone.0163431
Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med. 2003;348(21):2110–24.
pubmed: 12761368
doi: 10.1056/NEJMra021261
Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004;5(9):709–20.
pubmed: 15322529
doi: 10.1038/nrn1496
Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7(2):249–71.
pubmed: 10637364
doi: 10.2174/0929867003375335
Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, et al. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014;121(5):978–89.
pubmed: 25187999
doi: 10.1097/ALN.0000000000000419
Pai A, Heining M. Ketamine. Continuing Educ Anaesth Crit Care Pain. 2007;7(2):59–63.
doi: 10.1093/bjaceaccp/mkm008
Sleigh J, Harvey M, Voss L, Denny B. Ketamine – more mechanisms of action than just NMDA blockade. Trends Anaesth Crit Care. 2014;4(2):76–81.
doi: 10.1016/j.tacc.2014.03.002
Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for anesthesiologists: part I: background and basic signatures. Anesthesiology. 2015;123(4):937–60.
pubmed: 26275092
doi: 10.1097/ALN.0000000000000841
Rampil IJ. A primer for EEG signal processing in anesthesia. Anesthesiology. 1998;89(4):980–1002.
pubmed: 9778016
doi: 10.1097/00000542-199810000-00023
Drover DR, Lemmens HJ, Pierce ET, Plourde G, Loyd G, Ornstein E, Prichep LS, Chabot RJ, Gugino L. Patient State Index: titration of delivery and recovery from propofol, alfentanil, and nitrous oxide anesthesia. Anesthesiology. 2002;97(1):82–9.
pubmed: 12131107
doi: 10.1097/00000542-200207000-00012
Seeber M, Cantonas LM, Hoevels M, Sesia T, Visser-Vandewalle V, Michel CM. Subcortical electrophysiological activity is detectable with high-density EEG source imaging. Nat Commun. 2019;10(1):753.
pubmed: 30765707
pmcid: 6376013
doi: 10.1038/s41467-019-08725-w
Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18(7):e3000410.
pubmed: 32663219
pmcid: 7360023
doi: 10.1371/journal.pbio.3000410
Council NR. Guide for the Care and Use of Laboratory animals: Eighth Edition. Washington, DC: The National Academies; 2011.
Fenzl T, Touma C, Romanowski CPN, Ruschel J, Holsboer F, Landgraf R, Kimura M, Yassouridis A. Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. BMC Neurosci. 2011;12(1):29.
pubmed: 21435199
pmcid: 3068984
doi: 10.1186/1471-2202-12-29
Fritz EM, Kreuzer M, Altunkaya A, Singewald N, Fenzl T. Altered sleep behavior in a genetic mouse model of impaired fear extinction. Sci Rep. 2021;11(1):8978.
pubmed: 33903668
pmcid: 8076259
doi: 10.1038/s41598-021-88475-2
Koehl M, Battle SE, Turek FW. Sleep in female mice: a strain comparison across the estrous cycle. Sleep. 2003;26(3):267–72.
pubmed: 12749544
doi: 10.1093/sleep/26.3.267
Obert DP, Killing D, Happe T, Altunkaya A, Schneider G, Kreuzer M, Fenzl T. Combined implanted central venous access and cortical recording electrode array in freely behaving mice. MethodsX. 2021;8:101466.
pubmed: 35004192
pmcid: 8720795
doi: 10.1016/j.mex.2021.101466
Fenzl T, Romanowski CP, Flachskamm C, Honsberg K, Boll E, Hoehne A, Kimura M. Fully automated sleep deprivation in mice as a tool in sleep research. J Neurosci Methods. 2007;166(2):229–35.
pubmed: 17825425
doi: 10.1016/j.jneumeth.2007.07.007
Hartner L, Keil TW, Kreuzer M, Fritz EM, Wenning GK, Stefanova N, Fenzl T. Distinct parameters in the EEG of the PLP alpha-SYN mouse model for multiple system atrophy reinforce face Validity. Front Behav Neurosci. 2016;10:252.
pubmed: 28119583
Paxinos G, Keith BJ, Franklin M. The mouse brain in stereotaxic coordinates. Elsevier Science; 2007.
Shanker A, Abel JH, Schamberg G, Brown EN. Etiology of Burst suppression EEG patterns. Front Psychol 2021, 12.
Obara S. Dexmedetomidine as an adjuvant during general anesthesia. J Anesth. 2018;32(3):313–5.
pubmed: 29766277
doi: 10.1007/s00540-018-2509-5
Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods. 2004;134(1):9–21.
pubmed: 15102499
doi: 10.1016/j.jneumeth.2003.10.009
Chang CY, Hsu SH, Pion-Tonachini L, Jung TP. Evaluation of Artifact Subspace Reconstruction for Automatic EEG artifact removal. Annu Int Conf IEEE Eng Med Biol Soc. 2018;2018:1242–5.
pubmed: 30440615
Babiloni C, Barry RJ, Başar E, Blinowska KJ, Cichocki A, Drinkenburg WHIM, Klimesch W, Knight RT, Lopes da Silva F, Nunez P, et al. International Federation of Clinical Neurophysiology (IFCN) – EEG research workgroup: recommendations on frequency and topographic analysis of resting state EEG rhythms. Part 1: applications in clinical research studies. Clin Neurophysiol. 2020;131(1):285–307.
pubmed: 31501011
doi: 10.1016/j.clinph.2019.06.234
Uygun DS, Katsuki F, Bolortuya Y, Aguilar DD, McKenna JT, Thankachan S, McCarley RW, Basheer R, Brown RE, Strecker RE et al. Validation of an automated sleep spindle detection method for mouse electroencephalography. Sleep 2019, 42(2).
Kim D, Hwang E, Lee M, Sung H, Choi JH. Characterization of topographically specific sleep spindles in mice. Sleep. 2015;38(1):85–96.
pubmed: 25325451
pmcid: 4262960
doi: 10.5665/sleep.4330
Akima H. A new method of interpolation and smooth curve fitting based on local procedures. J ACM. 1970;17(4):589–602.
doi: 10.1145/321607.321609
Hentschke H, Stuttgen MC. Computation of measures of effect size for neuroscience data sets. Eur J Neurosci. 2011;34(12):1887–94.
pubmed: 22082031
doi: 10.1111/j.1460-9568.2011.07902.x
Mandrekar JN. Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol. 2010;5(9):1315–6.
pubmed: 20736804
doi: 10.1097/JTO.0b013e3181ec173d
Anders M, Anders B, Dreismickenbecker E, Hight D, Kreuzer M, Walter C, Zinn S. EEG responses to standardised noxious stimulation during clinical anaesthesia: a pilot study. BJA Open. 2023;5:100118.
pubmed: 37587999
doi: 10.1016/j.bjao.2022.100118
Ostertag J, Engelhard A, Nuttall R, Aydin D, Schneider G, García PS, Hinzmann D, Sleigh JW, Kratzer S, Kreuzer M. Development of Postanesthesia Care Unit Delirium is Associated with differences in Aperiodic and periodic alpha parameters of the Electroencephalogram during Emergence from General Anesthesia: results from a prospective Observational Cohort Study. Anesthesiology. 2024;140(1):73–84.
pubmed: 37815856
doi: 10.1097/ALN.0000000000004797
Laubach M, Amarante LM, Swanson K, White SR. What, if anything, is Rodent Prefrontal Cortex? eNeuro 2018, 5(5).
Carlén M. What constitutes the prefrontal cortex? Science. 2017;358(6362):478–82.
pubmed: 29074767
doi: 10.1126/science.aan8868
Beauchamp A, Yee Y, Darwin BC, Raznahan A, Mars RB, Lerch JP. Whole-brain comparison of rodent and human brains using spatial transcriptomics. Elife 2022, 11.
Guedel AE. Stages of Anesthesia and a re-classification of the signs of Anesthesia*. Anesth Analgesia. 1927;6(4):157–62.
doi: 10.1213/00000539-192708000-00001
Gibbs FA, Gibbs EL, Lennox WG. Effect on the electroencephalogram of certain drugs which influence nervous acitivity. Arch Intern Med. 1937;60(1):154–66.
doi: 10.1001/archinte.1937.00180010159012
Gugino LD, Chabot RJ, Prichep LS, John ER, Formanek V, Aglio LS. Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane. Br J Anaesth. 2001;87(3):421–8.
pubmed: 11517126
doi: 10.1093/bja/87.3.421
Kuizenga K, Wierda JM, Kalkman CJ. Biphasic EEG changes in relation to loss of consciousness during induction with thiopental, propofol, etomidate, midazolam or sevoflurane. Br J Anaesth. 2001;86(3):354–60.
pubmed: 11573524
doi: 10.1093/bja/86.3.354
McCarthy MM, Brown EN, Kopell N. Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation. J Neurosci. 2008;28(50):13488–504.
pubmed: 19074022
pmcid: 2717965
doi: 10.1523/JNEUROSCI.3536-08.2008
Bastos AM, Donoghue JA, Brincat SL, Mahnke M, Yanar J, Correa J, Waite AS, Lundqvist M, Roy J, Brown EN, et al. Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation. eLife. 2021;10:e60824.
pubmed: 33904411
pmcid: 8079153
doi: 10.7554/eLife.60824
Maechler M, Rösner J, Wallach I, Geiger JRP, Spies C, Liotta A, Berndt N. Sevoflurane effects on Neuronal Energy Metabolism Correlate with Activity States while mitochondrial function remains intact. Int J Mol Sci 2022, 23(6).
Xiao J, Chen Z, Yu B. A potential mechanism of Sodium Channel mediating the General Anesthesia Induced by Propofol. Front Cell Neurosci 2020, 14.
Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane induces coherent slow-Delta oscillations in rats. Front Neural Circuits 2017, 11(36).
Blain-Moraes S, Tarnal V, Vanini G, Alexander A, Rosen D, Shortal B, Janke E, Mashour GA. Neurophysiological correlates of sevoflurane-induced unconsciousness. Anesthesiology. 2015;122(2):307–16.
pubmed: 25296108
doi: 10.1097/ALN.0000000000000482
Wise SP. Forward frontal fields: phylogeny and fundamental function. Trends Neurosci. 2008;31(12):599–608.
pubmed: 18835649
pmcid: 2587508
doi: 10.1016/j.tins.2008.08.008
Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, et al. Shared and distinct transcriptomic cell types across neocortical areas. Nature. 2018;563(7729):72–8.
pubmed: 30382198
pmcid: 6456269
doi: 10.1038/s41586-018-0654-5
Hemmings HC Jr., Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. 2005;26(10):503–10.
pubmed: 16126282
doi: 10.1016/j.tips.2005.08.006
Bormann J. The ‘ABC’ of GABA receptors. Trends Pharmacol Sci. 2000;21(1):16–9.
pubmed: 10637650
doi: 10.1016/S0165-6147(99)01413-3
Bai D, Pennefather PS, MacDonald JF, Orser BA. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci. 1999;19(24):10635–46.
pubmed: 10594047
pmcid: 6784967
doi: 10.1523/JNEUROSCI.19-24-10635.1999
Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, et al. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013;110(12):E1142–1151.
pubmed: 23487781
pmcid: 3607036
doi: 10.1073/pnas.1221180110
Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of alpha rhythms during propofol-induced unconsciousness. J Neurosci. 2013;33(27):11070–5.
pubmed: 23825412
pmcid: 3718379
doi: 10.1523/JNEUROSCI.5670-12.2013
Lozano-Soldevilla D. On the physiological modulation and potential mechanisms underlying parieto-occipital alpha oscillations. Front Comput Neurosci. 2018;12:23.
pubmed: 29670518
pmcid: 5893851
doi: 10.3389/fncom.2018.00023
Cartailler J, Parutto P, Touchard C, Vallee F, Holcman D. Alpha rhythm collapse predicts iso-electric suppressions during anesthesia. Commun Biol. 2019;2:327.
pubmed: 31508502
pmcid: 6718680
doi: 10.1038/s42003-019-0575-3
Milinski L, Fisher SP, Cui N, McKillop LE, Blanco-Duque C, Ang G, Yamagata T, Bannerman DM, Vyazovskiy VV. Waking experience modulates sleep need in mice. BMC Biol. 2021;19(1):65.
pubmed: 33823872
pmcid: 8025572
doi: 10.1186/s12915-021-00982-w
Tobler I, Achermann P. Sleep homeostasis. Scholarpedia. 2007;2:2432.
doi: 10.4249/scholarpedia.2432
Vijay R, Kaushal N, Gozal D. Sleep fragmentation modifies EEG delta power during slow wave sleep in socially isolated and paired mice. Sleep Sci 2008, 2.
Huber R, Deboer T, Tobler I. Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations. Brain Res. 2000;857(1–2):8–19.
pubmed: 10700548
doi: 10.1016/S0006-8993(99)02248-9
Jasper JR, Lesnick JD, Chang LK, Yamanishi SS, Chang TK, Hsu SA, Daunt DA, Bonhaus DW, Eglen RM. Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998;55(7):1035–43.
pubmed: 9605427
doi: 10.1016/S0006-2952(97)00631-X
Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci. 2008;9(5):370–86.
pubmed: 18425091
doi: 10.1038/nrn2372
Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M. Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. J Clin Invest. 1996;98(5):1076–80.
pubmed: 8787667
pmcid: 507526
doi: 10.1172/JCI118887
Weerink MAS, Struys M, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical pharmacokinetics and pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet. 2017;56(8):893–913.
pubmed: 28105598
pmcid: 5511603
doi: 10.1007/s40262-017-0507-7
Huupponen E, Maksimow A, Lapinlampi P, Särkelä M, Saastamoinen A, Snapir A, Scheinin H, Scheinin M, Meriläinen P, Himanen SL, et al. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand. 2008;52(2):289–94.
pubmed: 18005372
doi: 10.1111/j.1399-6576.2007.01537.x
Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, Fried I, Tononi G. Regional slow waves and spindles in human sleep. Neuron. 2011;70(1):153–69.
pubmed: 21482364
pmcid: 3108825
doi: 10.1016/j.neuron.2011.02.043
Steriade M, Amzica F. Coalescence of sleep rhythms and their chronology in corticothalamic networks. Sleep Res Online. 1998;1(1):1–10.
pubmed: 11382851
Orser Beverley A, Pennefather Peter S, MacDonald John F. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors Anesthesiology 1997, 86(4):903–17.
Gerhard DM, Pothula S, Liu RJ, Wu M, Li XY, Girgenti MJ, Taylor SR, Duman CH, Delpire E, Picciotto M, et al. GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions. J Clin Invest. 2020;130(3):1336–49.
pubmed: 31743111
pmcid: 7269589
doi: 10.1172/JCI130808
Pinault D. N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex. Biol Psychiatry. 2008;63(8):730–5.
pubmed: 18022604
doi: 10.1016/j.biopsych.2007.10.006
Chapotot F, Gronfier C, Jouny C, Muzet A, Brandenberger G. Cortisol Secretion is related to Electroencephalographic alertness in human subjects during daytime Wakefulness1. J Clin Endocrinol Metabolism. 1998;83(12):4263–8.
Borsook D, George E, Kussman B, Becerra L. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010;92(4):601–12.
pubmed: 20727935
doi: 10.1016/j.pneurobio.2010.08.006
Obert DP, Sepulveda P, Kratzer S, Schneider G, Kreuzer M. The influence of induction speed on the frontal (processed) EEG. Sci Rep. 2020;10(1):19444.
pubmed: 33173114
pmcid: 7655958
doi: 10.1038/s41598-020-76323-8
Navarro KL, Huss M, Smith JC, Sharp P, Marx JO, Pacharinsak C. Mouse anesthesia: the art and science. Ilar j. 2021;62(1–2):238–73.
pubmed: 34180990
pmcid: 9236661
doi: 10.1093/ilar/ilab016
Maheshwari A. Rodent EEG: expanding the spectrum of analysis. Epilepsy Currents. 2020;20(3):149–53.
pubmed: 32354231
pmcid: 7281905
doi: 10.1177/1535759720921377
Eskola H, Toivo T, Laarne P, Lahtinen A, Meretoja AP, Lang H, Malmivuo J. Effect of the skull on scalp potentials. In: 1998: IEEE: 7–8.
Petroff OA, Spencer DD, Goncharova II, Zaveri HP. A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms. Clin Neurophysiol. 2016;127(2):1108–12.
pubmed: 26386645
doi: 10.1016/j.clinph.2015.08.004
van der Meer MA, Redish AD. Low and high Gamma oscillations in Rat ventral striatum have distinct relationships to Behavior, reward, and spiking activity on a learned spatial decision Task. Front Integr Neurosci. 2009;3:9.
pubmed: 19562092
pmcid: 2701683