The implications of APOBEC3-mediated C-to-U RNA editing for human disease.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
04 May 2024
04 May 2024
Historique:
received:
11
07
2023
accepted:
24
04
2024
medline:
5
5
2024
pubmed:
5
5
2024
entrez:
4
5
2024
Statut:
epublish
Résumé
Intra-organism biodiversity is thought to arise from epigenetic modification of constituent genes and post-translational modifications of translated proteins. Here, we show that post-transcriptional modifications, like RNA editing, may also contribute. RNA editing enzymes APOBEC3A and APOBEC3G catalyze the deamination of cytosine to uracil. RNAsee (RNA site editing evaluation) is a computational tool developed to predict the cytosines edited by these enzymes. We find that 4.5% of non-synonymous DNA single nucleotide polymorphisms that result in cytosine to uracil changes in RNA are probable sites for APOBEC3A/G RNA editing; the variant proteins created by such polymorphisms may also result from transient RNA editing. These polymorphisms are associated with over 20% of Medical Subject Headings across ten categories of disease, including nutritional and metabolic, neoplastic, cardiovascular, and nervous system diseases. Because RNA editing is transient and not organism-wide, future work is necessary to confirm the extent and effects of such editing in humans.
Identifiants
pubmed: 38704509
doi: 10.1038/s42003-024-06239-w
pii: 10.1038/s42003-024-06239-w
doi:
Substances chimiques
Cytidine Deaminase
EC 3.5.4.5
APOBEC3A protein, human
EC 3.5.4.5
Cytosine
8J337D1HZY
APOBEC-3G Deaminase
EC 3.5.4.5
Uracil
56HH86ZVCT
APOBEC3G protein, human
EC 3.5.4.5
APOBEC3 proteins, human
EC 3.5.4.5
Proteins
0
Cytosine Deaminase
EC 3.5.4.1
APOBEC Deaminases
EC 3.5.4.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529Subventions
Organisme : U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM)
ID : LMT1512495
Organisme : U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM)
ID : LMR1514213
Organisme : U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM)
ID : LMT15012495
Informations de copyright
© 2024. The Author(s).
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