Continuous and bilevel positive airway pressure may improve radiotherapy delivery in patients with intra-thoracic tumors.
BiPAP
CPAP
Non-invasive ventilation
Radiotherapy
Journal
Clinical and translational radiation oncology
ISSN: 2405-6308
Titre abrégé: Clin Transl Radiat Oncol
Pays: Ireland
ID NLM: 101713416
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
received:
30
11
2023
revised:
11
04
2024
accepted:
20
04
2024
medline:
6
5
2024
pubmed:
6
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
Minimizing tumor motion in radiotherapy for intra-thoracic tumors reduces side-effects by limiting radiation exposure to healthy tissue. Continuous or Bilevel Positive Airway Pressure (CPAP/BiPAP) could achieve this, since it could increase lung inflation and decrease tidal volume variability. We aim to identify the better CPAP/BiPAP setting for minimizing tumor motion. In 10 patients (5 with lung cancer, 5 with other intra-thoracic tumors), CPAP/BiPAP was tested with the following settings for 10 min each: CPAP 5, 10 and 15 cmH Nine out of ten patients tolerated all settings; one patient could not sustain CPAP-15. A significant difference in EELI was observed between settings (χ This study shows that the application of different settings of CPAP/BiPAP in patients with intra-thoracic tumors is feasible and tolerable. BiPAP with a higher BURR may offer the greatest potential for mitigating tumor motion among the applied settings, although further research investigating tumor motion should be conducted.
Sections du résumé
Background
UNASSIGNED
Minimizing tumor motion in radiotherapy for intra-thoracic tumors reduces side-effects by limiting radiation exposure to healthy tissue. Continuous or Bilevel Positive Airway Pressure (CPAP/BiPAP) could achieve this, since it could increase lung inflation and decrease tidal volume variability. We aim to identify the better CPAP/BiPAP setting for minimizing tumor motion.
Methods
UNASSIGNED
In 10 patients (5 with lung cancer, 5 with other intra-thoracic tumors), CPAP/BiPAP was tested with the following settings for 10 min each: CPAP 5, 10 and 15 cmH
Results
UNASSIGNED
Nine out of ten patients tolerated all settings; one patient could not sustain CPAP-15. A significant difference in EELI was observed between settings (χ
Conclusions
UNASSIGNED
This study shows that the application of different settings of CPAP/BiPAP in patients with intra-thoracic tumors is feasible and tolerable. BiPAP with a higher BURR may offer the greatest potential for mitigating tumor motion among the applied settings, although further research investigating tumor motion should be conducted.
Identifiants
pubmed: 38706725
doi: 10.1016/j.ctro.2024.100784
pii: S2405-6308(24)00061-2
pmc: PMC11063599
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100784Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J. Elshof reports a grant from Fisher&Paykel and grants and personal fees from Vivisol B.V., outside the submitted work. C.M. Steenstra reports no declarations of interest. A.G.H. Niezink and R. Wijsman report that the department of radiation oncology of the UMCG has research collaborations with Elekta, IBA, RaySearch, Siemens and Mirada. P.J. Wijkstra reports a consulting fee from Philips and his role as treasurer for the European Respiratory Society, outside the submitted work. M.L. Duiverman reports grants form Philips B.V., Fisher & Paykel, Vivisol B.V., Resmed Ltd and Löwenstein B.V, personal fees from Vivisol B.V., Resmed Ltd., Novartis, Chiesi, Breas, AstraZeneca, and her role as chair of Assembly 2 for the European Respiratory Society, outside the submitted work.