Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC).
Leigh syndrome French Canadian type
cardiomyocyte cells
disease modeling
hepatocyte-like cells
induced pluripotent stem cells
three germ layers
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2024
2024
Historique:
received:
23
01
2024
accepted:
02
04
2024
medline:
6
5
2024
pubmed:
6
5
2024
entrez:
6
5
2024
Statut:
epublish
Résumé
Leigh syndrome French Canadian type (LSFC) is a recessive neurodegenerative disease characterized by tissue-specific deficiency in cytochrome c oxidase (COX), the fourth complex in the oxidative phosphorylation system. LSFC is caused by mutations in the leucine rich pentatricopeptide repeat containing gene (
Identifiants
pubmed: 38706791
doi: 10.3389/fgene.2024.1375467
pii: 1375467
pmc: PMC11066297
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1375467Informations de copyright
Copyright © 2024 Gélinas, Lévesque, Thompson Legault, Rivard, Villeneuve, Laprise and Rioux.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.